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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: ZNF281

Summary for ZNF281

Gene information	Gene symbol	ZNF281
	Ensembl ID	ENSG00000162702
	Entrez ID	23528
	Gene name	zinc finger protein 281
	Synonyms	ZBP-99
	Gene type	protein_coding
	UniProtAcc	Q9Y2X9

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Dataset with differentially expressed gene: ZNF281

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.310464	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.266125	9.24e-11
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.513699	1.80e-26

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Expression of ZNF281 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZNF281

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZNF281

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZNF281	hsa-miR-603	89.1024	NM_001281293
ZNF281	hsa-miR-362-3p	89.1024	NM_001281293
ZNF281	hsa-miR-495-3p	88.9778	NM_001281293
ZNF281	hsa-miR-3929	88.784	NM_001281293
ZNF281	hsa-miR-34a-5p	88.6898	NM_001281293
ZNF281	hsa-miR-449a	88.6898	NM_001281293
ZNF281	hsa-miR-4639-5p	88.3117	NM_001281293
ZNF281	hsa-miR-4324	88.2262	NM_001281293
ZNF281	hsa-miR-670-5p	87.3215	NM_001281293
ZNF281	hsa-miR-487a-3p	87.0692	NM_001281293
ZNF281	hsa-miR-154-3p	87.0692	NM_001281293
ZNF281	hsa-miR-449b-5p	86.6741	NM_001281293
ZNF281	hsa-miR-34c-5p	86.6741	NM_001281293
ZNF281	hsa-miR-374c-5p	86.6368	NM_001281293
ZNF281	hsa-miR-655-3p	86.6368	NM_001281293
ZNF281	hsa-miR-548ar-3p	86.067	NM_001281293
ZNF281	hsa-miR-2278	85.8705	NM_001281293
ZNF281	hsa-miR-6128	85.639	NM_001281293
ZNF281	hsa-miR-3910	85.3683	NM_001281293
ZNF281	hsa-miR-548az-3p	85.0773	NM_001281293
ZNF281	hsa-miR-548f-3p	85.0773	NM_001281293
ZNF281	hsa-miR-548e-3p	85.0773	NM_001281293
ZNF281	hsa-miR-548bc	85.0773	NM_001281293
ZNF281	hsa-miR-548a-3p	85.0773	NM_001281293
ZNF281	hsa-miR-4495	84.8396	NM_001281293
ZNF281	hsa-miR-1248	84.6831	NM_001281293
ZNF281	hsa-miR-3973	84.3356	NM_001281293
ZNF281	hsa-miR-4666a-5p	83.6789	NM_001281293
ZNF281	hsa-miR-4517	83.288	NM_001281293
ZNF281	hsa-miR-8070	83.1923	NM_001281293
ZNF281	hsa-miR-548g-3p	82.8497	NM_001281293
ZNF281	hsa-miR-152-5p	82.7769	NM_001281293
ZNF281	hsa-miR-106a-3p	82.2077	NM_001281293
ZNF281	hsa-miR-4273	82.1981	NM_001281293
ZNF281	hsa-miR-196a-5p	81.6754	NM_001281293
ZNF281	hsa-miR-6831-5p	81.6754	NM_001281293
ZNF281	hsa-miR-196b-5p	81.6754	NM_001281293
ZNF281	hsa-miR-1284	81.4393	NM_001281293
ZNF281	hsa-miR-3938	81.4154	NM_001281293
ZNF281	hsa-miR-548e-5p	80.5705	NM_001281293
ZNF281	hsa-miR-8087	80.172	NM_001281293
ZNF281	hsa-miR-4432	80.172	NM_001281293

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Motifs and transcription factors (TFs) regulating ZNF281

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZNF281	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ZNF281	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ZNF281	transfac_pro__M07397	ZNF148 (directAnnotation).
ZNF281	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
ZNF281	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
ZNF281	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
ZNF281	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ZNF281	metacluster_7.13	ZFX (directAnnotation).
ZNF281	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
ZNF281	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
ZNF281	transfac_pro__M01175	ZBTB7B (directAnnotation).
ZNF281	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ZNF281	tfdimers__MD00151	CHURC1 (directAnnotation).
ZNF281	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ZNF281	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
ZNF281	transfac_pro__M01303	SP1 (directAnnotation).
ZNF281	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ZNF281	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ZNF281	transfac_pro__M02090	E2F4 (directAnnotation).
ZNF281	transfac_pro__M01714	KLF15 (directAnnotation).
ZNF281	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
ZNF281	jaspar__MA1122.1	TFDP1 (directAnnotation).
ZNF281	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
ZNF281	transfac_pro__M02089	E2F3 (directAnnotation).
ZNF281	transfac_pro__M12604	ZNF444 (directAnnotation).
ZNF281	metacluster_3.14	WT1; WT1 (directAnnotation).
ZNF281	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
ZNF281	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
ZNF281	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
ZNF281	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ZNF281	cisbp__M07938	E2F1 (directAnnotation).
ZNF281	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).
ZNF281	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
ZNF281	transfac_pro__M07436	WT1 (directAnnotation).
ZNF281	transfac_pro__M02281	SP1 (directAnnotation).
ZNF281	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
ZNF281	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ZNF281	transfac_pro__M02898	SMAD3 (directAnnotation).
ZNF281	transfac_public__M00491	PATZ1 (directAnnotation).
ZNF281	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ZNF281	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
ZNF281	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ZNF281	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
ZNF281	transfac_pro__M00652	NRF1 (directAnnotation).
ZNF281	transfac_pro__M04918	EGR1 (directAnnotation).
ZNF281	jaspar__MA0079.5	SP1 (directAnnotation).
ZNF281	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
ZNF281	transfac_pro__M01253	CNOT3 (directAnnotation).
ZNF281	transfac_pro__M04817	ZBTB33 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
ZNF281	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	up	Malignant cells	GSE138267	NA

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."