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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZFP91

Summary for ZFP91

Gene information	Gene symbol	ZFP91
	Ensembl ID	ENSG00000186660
	Entrez ID	80829
	Gene name	ZFP91 zinc finger protein, atypical E3 ubiquitin ligase
	Synonyms	PZF\|ZNF757
	Gene type	protein_coding
	UniProtAcc	Q96JP5

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Dataset with differentially expressed gene: ZFP91

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.27927	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.63922	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.393289	1.90e-30

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Expression of ZFP91 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZFP91

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZFP91

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZFP91	hsa-miR-103a-2-5p	85.3425	NM_001197051
ZFP91	hsa-miR-3667-3p	85.0621	NM_001197051
ZFP91	hsa-miR-19a-3p	84.5851	NM_001197051
ZFP91	hsa-miR-19b-3p	84.5851	NM_001197051
ZFP91	hsa-miR-4802-5p	84.5736	NM_001197051
ZFP91	hsa-miR-1843	84.5736	NM_001197051
ZFP91	hsa-miR-595	83.5463	NM_001197051
ZFP91	hsa-miR-2278	82.7447	NM_001197051
ZFP91	hsa-miR-6738-3p	82.348	NM_001197051
ZFP91	hsa-miR-3163	82.1147	NM_001197051
ZFP91	hsa-miR-548n	81.7951	NM_001197051
ZFP91	hsa-miR-519c-3p	81.7564	NM_001197051
ZFP91	hsa-miR-519a-3p	81.7564	NM_001197051
ZFP91	hsa-miR-519b-3p	81.7564	NM_001197051
ZFP91	hsa-miR-548c-3p	81.7527	NM_001197051
ZFP91	hsa-miR-607	81.1965	NM_001197051
ZFP91	hsa-miR-499b-5p	81.0839	NM_001197051
ZFP91	hsa-miR-6867-5p	80.9628	NM_001197051
ZFP91	hsa-miR-6814-5p	80.8894	NM_001197051
ZFP91	hsa-miR-6825-5p	80.3892	NM_001197051
ZFP91	hsa-miR-3973	80.0537	NM_001197051

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Motifs and transcription factors (TFs) regulating ZFP91

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZFP91	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
ZFP91	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
ZFP91	hdpi__ETV4	ETV4 (directAnnotation).
ZFP91	jaspar__MA1933.1	SREBF2 (directAnnotation).
ZFP91	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ZFP91	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ZFP91	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ZFP91	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ZFP91	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ZFP91	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ZFP91	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
ZFP91	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
ZFP91	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
ZFP91	jaspar__MA0748.2	YY2 (directAnnotation).
ZFP91	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ZFP91	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ZFP91	transfac_pro__M00938	E2F1 (directAnnotation).
ZFP91	transfac_pro__M04893	TAF1 (directAnnotation).
ZFP91	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
ZFP91	tfdimers__MD00364	WT1 (directAnnotation).
ZFP91	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
ZFP91	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
ZFP91	tfdimers__MD00552	USF2; ZBTB14 (directAnnotation).
ZFP91	taipale_tf_pairs__ETV5_EOMES_RNGTGNNNNNNNNNNNNNRCRCCGGAWSN_CAP	EOMES; ETV5 (directAnnotation).
ZFP91	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
ZFP91	transfac_pro__M07387	ZBTB7A (directAnnotation).
ZFP91	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
ZFP91	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
ZFP91	metacluster_144.13	HIC1; HIC1 (directAnnotation).
ZFP91	transfac_pro__M00514	ATF4 (directAnnotation).
ZFP91	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ZFP91	transfac_pro__M02898	SMAD3 (directAnnotation).
ZFP91	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ZFP91	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
ZFP91	metacluster_126.4	ZNF12; ZNF12; ZNF44; ZNF563; ZNF93 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."