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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZFP36L1

Summary for ZFP36L1

Gene information	Gene symbol	ZFP36L1
	Ensembl ID	ENSG00000185650
	Entrez ID	677
	Gene name	ZFP36 ring finger protein like 1
	Synonyms	Berg36\|BRF1\|cMG1\|ERF1\|RNF162B\|TIS11B
	Gene type	protein_coding
	UniProtAcc	Q07352

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Dataset with differentially expressed gene: ZFP36L1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.627041	0.00e+00
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.644591	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.350022	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	0.250719	3.32e-30
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	-0.447149	9.81e-45
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	0.284278	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	B cells	0.478771	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.53286	2.35e-14
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.398652	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.468169	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.48961	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.399392	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	-0.255434	4.83e-02
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Plasma cells	0.48526	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.590378	1.36e-10
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	0.33348	0.00e+00
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	Mono/Macro	-0.291069	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD4+ T cells	-0.452467	1.62e-14
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.572538	1.30e-26
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	-0.700003	3.72e-06
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.450794	2.52e-28
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.396353	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.645212	1.43e-31
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.866687	4.54e-13
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	NK cells	-0.419125	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.385651	5.14e-40
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.812193	1.55e-14
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	1.01045	7.01e-09
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.823799	7.31e-23
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.666831	2.25e-08
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	NK cells	-0.251819	6.33e-09
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	CD4+ T cells	-0.361607	2.11e-02
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.525107	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-1.18481	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.346153	1.94e-20
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.268426	2.67e-06
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.282614	5.56e-24
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.593782	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.295055	0.00e+00

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Expression of ZFP36L1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZFP36L1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZFP36L1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZFP36L1	hsa-miR-4286	89.7868	NM_001244698
ZFP36L1	hsa-miR-4657	89.753	NM_001244698
ZFP36L1	hsa-miR-4491	89.753	NM_001244698
ZFP36L1	hsa-miR-4766-5p	89.4434	NM_001244698
ZFP36L1	hsa-miR-6809-3p	89.3764	NM_004926
ZFP36L1	hsa-miR-3680-3p	88.8321	NM_001244698
ZFP36L1	hsa-miR-92a-2-5p	88.8109	NM_004926
ZFP36L1	hsa-miR-5588-3p	88.7561	NM_004926
ZFP36L1	hsa-miR-31-5p	88.6815	NM_004926
ZFP36L1	hsa-miR-193b-5p	88.2931	NM_004926
ZFP36L1	hsa-miR-491-5p	87.8196	NM_004926
ZFP36L1	hsa-miR-6760-5p	87.5133	NM_004926
ZFP36L1	hsa-miR-6516-5p	87.2237	NM_004926
ZFP36L1	hsa-miR-455-3p	86.4397	NM_004926
ZFP36L1	hsa-miR-498-5p	86.111	NM_004926
ZFP36L1	hsa-miR-3613-3p	85.9425	NM_001244698
ZFP36L1	hsa-miR-548g-3p	85.5092	NM_004926
ZFP36L1	hsa-miR-520d-5p	85.0228	NM_004926
ZFP36L1	hsa-miR-524-5p	85.0228	NM_004926
ZFP36L1	hsa-miR-3190-3p	84.4182	NM_001244698
ZFP36L1	hsa-miR-297	84.2331	NM_001244698
ZFP36L1	hsa-miR-4762-3p	84.0939	NM_001244698
ZFP36L1	hsa-miR-6512-5p	84.0841	NM_001244698
ZFP36L1	hsa-miR-548p	83.7012	NM_004926
ZFP36L1	hsa-miR-1910-5p	83.4687	NM_001244698
ZFP36L1	hsa-miR-6868-3p	83.4657	NM_001244698
ZFP36L1	hsa-miR-3679-3p	83.0536	NM_004926
ZFP36L1	hsa-miR-12136	82.1189	NM_001244698
ZFP36L1	hsa-miR-6887-5p	82.0043	NM_004926
ZFP36L1	hsa-miR-6795-5p	82.0043	NM_004926
ZFP36L1	hsa-miR-4775	81.8848	NM_004926
ZFP36L1	hsa-miR-5694	81.871	NM_001244698
ZFP36L1	hsa-miR-8063	81.5492	NM_001244698
ZFP36L1	hsa-miR-590-3p	81.4885	NM_001244698
ZFP36L1	hsa-miR-27b-5p	81.3938	NM_004926
ZFP36L1	hsa-miR-506-3p	81.3071	NM_004926
ZFP36L1	hsa-miR-124-3p	81.3071	NM_004926
ZFP36L1	hsa-miR-3143	81.1493	NM_001244698
ZFP36L1	hsa-miR-495-5p	80.7722	NM_004926
ZFP36L1	hsa-miR-6124	80.6587	NM_004926
ZFP36L1	hsa-miR-6859-5p	80.3242	NM_001244698
ZFP36L1	hsa-miR-3916	80.3242	NM_001244698
ZFP36L1	hsa-miR-3125	80.3242	NM_001244698
ZFP36L1	hsa-miR-6871-3p	80.2549	NM_001244698
ZFP36L1	hsa-miR-3182	80.0567	NM_004926
ZFP36L1	hsa-miR-6507-5p	80.0513	NM_001244698

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Motifs and transcription factors (TFs) regulating ZFP36L1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZFP36L1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
ZFP36L1	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
ZFP36L1	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
ZFP36L1	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
ZFP36L1	cisbp__M08198	ELF1 (directAnnotation).
ZFP36L1	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
ZFP36L1	metacluster_111.5	E4F1; E4F1 (directAnnotation).
ZFP36L1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ZFP36L1	transfac_pro__M02090	E2F4 (directAnnotation).
ZFP36L1	transfac_pro__M01714	KLF15 (directAnnotation).
ZFP36L1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
ZFP36L1	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
ZFP36L1	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
ZFP36L1	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
ZFP36L1	jaspar__MA0748.2	YY2 (directAnnotation).
ZFP36L1	taipale_tf_pairs__GCM1_CEBPB_MTRSGGGNNNNNTTRCGYAAN_CAP	CEBPB; GCM1 (directAnnotation).
ZFP36L1	metacluster_168.4	ZNF652 (directAnnotation).
ZFP36L1	transfac_pro__M04855	IRF4 (directAnnotation).
ZFP36L1	tfdimers__MD00475	FOS; FOSB; FOSL1; FOSL2; JUN; JUNB; JUND; ZNF333 (directAnnotation).
ZFP36L1	tfdimers__MD00408	ELF1; ELF2; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV4; ETV6; ETV7; FLI1; GABPA; GABPB1; GFI1; GFI1B; SPI1; SPIB (directAnnotation).
ZFP36L1	jaspar__MA1657.1	ZNF652 (directAnnotation).
ZFP36L1	jaspar__MA1489.1	FOXN3 (directAnnotation).
ZFP36L1	taipale_tf_pairs__TEAD4_ELK1_RCCGGANRNNCGGWATKN_CAP_repr	ELK1; TEAD4 (directAnnotation).
ZFP36L1	transfac_pro__M05412	ZNF579 (directAnnotation).
ZFP36L1	tfdimers__MD00012	ETS1; YY1 (directAnnotation).
ZFP36L1	transfac_pro__M05864	ZNF615 (directAnnotation).
ZFP36L1	cisbp__M04023	CREB1 (directAnnotation).
ZFP36L1	metacluster_167.5	EHF; ELF5; NFATC3; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIC; SPIC; STAT5A (directAnnotation). ETS1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPIB; SPIC (inferredBy_Orthology).
ZFP36L1	taipale_tf_pairs__JUN_ATGACGTCAT_HT	JUN (directAnnotation).
ZFP36L1	transfac_pro__M00679	NR2E1 (inferredBy_Orthology).
ZFP36L1	transfac_pro__M06883	ZNF600 (directAnnotation).
ZFP36L1	transfac_public__M00039	CREB1 (directAnnotation).
ZFP36L1	kznf__ZNF442_Imbeault2017_RP_RCADE	ZNF442 (directAnnotation).
ZFP36L1	transfac_pro__M06588	ZNF845 (directAnnotation).
ZFP36L1	transfac_pro__M07448	ZBED1 (directAnnotation).
ZFP36L1	transfac_pro__M01251	E2F1 (directAnnotation).
ZFP36L1	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
ZFP36L1	metacluster_152.2	TWIST1 (directAnnotation).
ZFP36L1	taipale_tf_pairs__ELK1_FOXI1_RSCGGAANRTMAAYA_CAP_repr	ELK1; FOXI1 (directAnnotation).
ZFP36L1	tfdimers__MD00572	CEBPA; CEBPB; CEBPD; CEBPE; CEBPG; ZNF333 (directAnnotation).
ZFP36L1	transfac_pro__M05856	ZNF565 (directAnnotation).
ZFP36L1	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
ZFP36L1	transfac_public__M00041	ATF2; JUN (directAnnotation).
ZFP36L1	tfdimers__MD00204	GABPA; NKX2-1 (directAnnotation).
ZFP36L1	transfac_public__M00237	AHR; ARNT (directAnnotation).
ZFP36L1	transfac_pro__M05966	ZFP14 (directAnnotation).
ZFP36L1	metacluster_130.2	ZNF182; ZNF22; ZNF225; ZNF225; ZNF285; ZNF362; ZNF362; ZNF384; ZNF487; ZNF512; ZNF570; ZNF613 (directAnnotation). ZNF384 (inferredBy_Orthology).
ZFP36L1	transfac_pro__M08796	THAP1 (directAnnotation).
ZFP36L1	transfac_pro__M07436	WT1 (directAnnotation).
ZFP36L1	hdpi__TFAM	TFAM (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."