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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZFAND3

Summary for ZFAND3

Gene information	Gene symbol	ZFAND3
	Ensembl ID	ENSG00000156639
	Entrez ID	60685
	Gene name	zinc finger AN1-type containing 3
	Synonyms	FLJ13222\|TEX27
	Gene type	protein_coding
	UniProtAcc	Q9H8U3

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Dataset with differentially expressed gene: ZFAND3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.257718	4.06e-16
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.292684	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.257305	7.88e-27
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.26309	0.00e+00

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Expression of ZFAND3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZFAND3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZFAND3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZFAND3	hsa-miR-513a-5p	81.5911	NM_021943
ZFAND3	hsa-miR-27b-3p	81.5911	NM_021943
ZFAND3	hsa-miR-6882-3p	81.4107	NM_021943
ZFAND3	hsa-miR-4690-5p	80.9428	NM_021943
ZFAND3	hsa-miR-6503-3p	80.8016	NM_021943
ZFAND3	hsa-miR-6791-5p	80.7867	NM_021943
ZFAND3	hsa-miR-4292	80.7867	NM_021943
ZFAND3	hsa-miR-335-3p	80.6575	NM_021943
ZFAND3	hsa-miR-4307	80.1644	NM_021943

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Motifs and transcription factors (TFs) regulating ZFAND3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZFAND3	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
ZFAND3	metacluster_52.11	ZNF184 (directAnnotation).
ZFAND3	metacluster_7.8	ZBTB7A; ZNF28 (directAnnotation).
ZFAND3	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
ZFAND3	metacluster_7.13	ZFX (directAnnotation).
ZFAND3	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ZFAND3	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
ZFAND3	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ZFAND3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ZFAND3	cisbp__M00249	WT1 (directAnnotation).
ZFAND3	cisbp__M01863	ZNF711 (inferredBy_Orthology).
ZFAND3	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
ZFAND3	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ZFAND3	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
ZFAND3	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ZFAND3	metacluster_151.2	ZNF23 (directAnnotation).
ZFAND3	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ZFAND3	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
ZFAND3	transfac_pro__M01199	TRIM28 (directAnnotation).
ZFAND3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ZFAND3	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
ZFAND3	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
ZFAND3	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
ZFAND3	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
ZFAND3	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
ZFAND3	cisbp__M00968	MTF2 (directAnnotation).
ZFAND3	jaspar__MA0748.2	YY2 (directAnnotation).
ZFAND3	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ZFAND3	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
ZFAND3	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ZFAND3	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
ZFAND3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ZFAND3	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
ZFAND3	transfac_pro__M07310	SP5 (directAnnotation).
ZFAND3	transfac_pro__M04893	TAF1 (directAnnotation).
ZFAND3	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
ZFAND3	metacluster_175.1	ZNF283 (directAnnotation).
ZFAND3	cisbp__M00788	ZFY (inferredBy_Orthology).
ZFAND3	tfdimers__MD00364	WT1 (directAnnotation).
ZFAND3	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
ZFAND3	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ZFAND3	transfac_pro__M04916	TAF1 (directAnnotation).
ZFAND3	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
ZFAND3	transfac_pro__M01973	PLAG1 (directAnnotation).
ZFAND3	tfdimers__MD00483	ZBTB14 (directAnnotation).
ZFAND3	metacluster_198.3	ZFP64 (directAnnotation).
ZFAND3	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ZFAND3	transfac_pro__M01303	SP1 (directAnnotation).
ZFAND3	metacluster_143.13	ZBTB7A (directAnnotation).
ZFAND3	taipale_tf_pairs__ETV5_EOMES_RNGTGNNNNNNNNNNNNNRCRCCGGAWSN_CAP	EOMES; ETV5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."