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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: ZBTB43

Summary for ZBTB43

Gene information	Gene symbol	ZBTB43
	Ensembl ID	ENSG00000169155
	Entrez ID	23099
	Gene name	zinc finger and BTB domain containing 43
	Synonyms	FLJ22470\|KIAA0414\|ZBTB22B\|ZNF-X\|ZNF297B
	Gene type	protein_coding
	UniProtAcc	O43298

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Dataset with differentially expressed gene: ZBTB43

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.423308	4.96e-23
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.279564	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-1.34824	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.737707	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	-0.317764	9.19e-08
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.33036	1.51e-18

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Expression of ZBTB43 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZBTB43

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZBTB43

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZBTB43	hsa-miR-4432	85.1269	NM_014007
ZBTB43	hsa-miR-1278	84.9293	NM_014007
ZBTB43	hsa-miR-1537-5p	84.5855	NM_001135776
ZBTB43	hsa-miR-6739-5p	84.3747	NM_014007
ZBTB43	hsa-miR-6733-5p	84.3747	NM_014007
ZBTB43	hsa-miR-23b-3p	84.0149	NM_001135776
ZBTB43	hsa-miR-23c	84.0149	NM_001135776
ZBTB43	hsa-miR-23a-3p	84.0149	NM_001135776
ZBTB43	hsa-miR-577	83.5074	NM_014007
ZBTB43	hsa-miR-448	83.427	NM_001135776
ZBTB43	hsa-miR-3915	82.7936	NM_014007
ZBTB43	hsa-miR-3153	82.3155	NM_014007
ZBTB43	hsa-miR-548d-3p	82.3125	NM_014007
ZBTB43	hsa-miR-561-3p	81.8336	NM_014007
ZBTB43	hsa-miR-24-1-5p	81.8181	NM_001135776
ZBTB43	hsa-miR-24-2-5p	81.8181	NM_001135776
ZBTB43	hsa-miR-29b-2-5p	81.6076	NM_001135776
ZBTB43	hsa-miR-3163	80.3785	NM_001135776
ZBTB43	hsa-miR-3194-5p	80.3519	NM_001135776
ZBTB43	hsa-miR-548bb-3p	80.1037	NM_014007
ZBTB43	hsa-miR-498-5p	80.0874	NM_001135776

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Motifs and transcription factors (TFs) regulating ZBTB43

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZBTB43	metacluster_157.2	ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
ZBTB43	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
ZBTB43	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
ZBTB43	transfac_pro__M04916	TAF1 (directAnnotation).
ZBTB43	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ZBTB43	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
ZBTB43	transfac_pro__M00652	NRF1 (directAnnotation).
ZBTB43	kznf__ZFP57_Imbeault2017_OM_MEME	ZFP57 (directAnnotation).
ZBTB43	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
ZBTB43	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ZBTB43	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
ZBTB43	jaspar__MA1721.1	ZNF93 (directAnnotation).
ZBTB43	metacluster_151.2	ZNF23 (directAnnotation).
ZBTB43	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ZBTB43	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
ZBTB43	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
ZBTB43	transfac_pro__M01199	TRIM28 (directAnnotation).
ZBTB43	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ZBTB43	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
ZBTB43	transfac_pro__M01253	CNOT3 (directAnnotation).
ZBTB43	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
ZBTB43	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
ZBTB43	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
ZBTB43	cisbp__M00968	MTF2 (directAnnotation).
ZBTB43	metacluster_7.13	ZFX (directAnnotation).
ZBTB43	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ZBTB43	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
ZBTB43	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
ZBTB43	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
ZBTB43	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ZBTB43	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
ZBTB43	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ZBTB43	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
ZBTB43	cisbp__M01863	ZNF711 (inferredBy_Orthology).
ZBTB43	transfac_pro__M07310	SP5 (directAnnotation).
ZBTB43	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ZBTB43	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
ZBTB43	transfac_pro__M00938	E2F1 (directAnnotation).
ZBTB43	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ZBTB43	transfac_pro__M04893	TAF1 (directAnnotation).
ZBTB43	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ZBTB43	transfac_pro__M04817	ZBTB33 (directAnnotation).
ZBTB43	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
ZBTB43	transfac_pro__M12697	ZNF142 (directAnnotation).
ZBTB43	metacluster_175.1	ZNF283 (directAnnotation).
ZBTB43	cisbp__M00788	ZFY (inferredBy_Orthology).
ZBTB43	tfdimers__MD00364	WT1 (directAnnotation).
ZBTB43	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
ZBTB43	hdpi__ZNF304	ZNF304 (directAnnotation).
ZBTB43	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
ZBTB43	metacluster_131.7	down	Mono/Macro	GSE164551	NA

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."