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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZBTB18

Summary for ZBTB18

Gene information	Gene symbol	ZBTB18
	Ensembl ID	ENSG00000179456
	Entrez ID	10472
	Gene name	zinc finger and BTB domain containing 18
	Synonyms	C2H2-171\|RP58\|TAZ-1\|ZNF238
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ZBTB18

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.381791	1.02e-16
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.341446	0.00e+00

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Expression of ZBTB18 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZBTB18

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZBTB18

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZBTB18	hsa-miR-3684	89.3539	NM_001278196
ZBTB18	hsa-miR-93-5p	89.0698	NM_006352
ZBTB18	hsa-miR-526b-3p	89.0698	NM_006352
ZBTB18	hsa-miR-519d-3p	89.0698	NM_006352
ZBTB18	hsa-miR-106a-5p	89.0698	NM_006352
ZBTB18	hsa-miR-20b-5p	89.0698	NM_006352
ZBTB18	hsa-miR-17-5p	89.0698	NM_006352
ZBTB18	hsa-miR-4275	89.0622	NM_001278196
ZBTB18	hsa-miR-3064-3p	89.0427	NM_001278196
ZBTB18	hsa-miR-20a-5p	88.8412	NM_006352
ZBTB18	hsa-miR-106b-5p	88.8412	NM_006352
ZBTB18	hsa-miR-148a-3p	88.509	NM_001278196
ZBTB18	hsa-miR-148b-3p	88.509	NM_001278196
ZBTB18	hsa-miR-152-3p	88.509	NM_001278196
ZBTB18	hsa-miR-455-3p	88.3009	NM_006352
ZBTB18	hsa-miR-6131	88.2553	NM_001278196
ZBTB18	hsa-miR-302c-5p	88.2529	NM_006352
ZBTB18	hsa-miR-656-3p	87.5371	NM_006352
ZBTB18	hsa-miR-4445-5p	87.4349	NM_001278196
ZBTB18	hsa-miR-30d-3p	87.0083	NM_001278196
ZBTB18	hsa-miR-30a-3p	87.0083	NM_001278196
ZBTB18	hsa-miR-30e-3p	87.0083	NM_001278196
ZBTB18	hsa-miR-1276	86.5869	NM_001278196
ZBTB18	hsa-miR-30c-5p	86.5769	NM_001278196
ZBTB18	hsa-miR-30a-5p	86.5769	NM_001278196
ZBTB18	hsa-miR-30e-5p	86.5769	NM_001278196
ZBTB18	hsa-miR-30d-5p	86.5769	NM_001278196
ZBTB18	hsa-miR-30b-5p	86.5769	NM_001278196
ZBTB18	hsa-miR-4803	86.4661	NM_006352
ZBTB18	hsa-miR-3175	86.3541	NM_006352
ZBTB18	hsa-miR-4720-3p	85.9887	NM_001278196
ZBTB18	hsa-miR-4521	85.9331	NM_006352
ZBTB18	hsa-miR-585-5p	85.8871	NM_006352
ZBTB18	hsa-miR-10399-5p	85.5976	NM_001278196
ZBTB18	hsa-miR-6499-3p	85.5833	NM_006352
ZBTB18	hsa-miR-4263	85.3333	NM_006352
ZBTB18	hsa-miR-6504-3p	85.2048	NM_001278196
ZBTB18	hsa-miR-143-5p	85.1674	NM_006352
ZBTB18	hsa-miR-4738-3p	85.1114	NM_001278196
ZBTB18	hsa-miR-1301-3p	85.0276	NM_006352
ZBTB18	hsa-miR-5047	85.0276	NM_006352
ZBTB18	hsa-miR-561-3p	84.6607	NM_006352
ZBTB18	hsa-miR-4261	84.1274	NM_001278196
ZBTB18	hsa-miR-6529-5p	84.0705	NM_006352
ZBTB18	hsa-miR-4744	84.031	NM_006352
ZBTB18	hsa-miR-2113	83.6387	NM_006352
ZBTB18	hsa-miR-6861-5p	83.5404	NM_006352
ZBTB18	hsa-miR-6833-3p	83.5193	NM_006352
ZBTB18	hsa-miR-582-5p	83.2403	NM_001278196
ZBTB18	hsa-miR-6083	82.9876	NM_001278196

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Motifs and transcription factors (TFs) regulating ZBTB18

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZBTB18	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
ZBTB18	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
ZBTB18	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
ZBTB18	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
ZBTB18	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
ZBTB18	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
ZBTB18	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
ZBTB18	metacluster_3.14	WT1; WT1 (directAnnotation).
ZBTB18	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
ZBTB18	cisbp__M07938	E2F1 (directAnnotation).
ZBTB18	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ZBTB18	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
ZBTB18	transfac_pro__M00652	NRF1 (directAnnotation).
ZBTB18	transfac_pro__M04918	EGR1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."