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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZBTB11

Summary for ZBTB11

Gene information	Gene symbol	ZBTB11
	Ensembl ID	ENSG00000066422
	Entrez ID	27107
	Gene name	zinc finger and BTB domain containing 11
	Synonyms	ZNF-U69274\|ZNF913
	Gene type	protein_coding
	UniProtAcc	O95625

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Dataset with differentially expressed gene: ZBTB11

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.332678	9.86e-24

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Expression of ZBTB11 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZBTB11

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZBTB11

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZBTB11	hsa-miR-4698	94.1429	NM_014415
ZBTB11	hsa-miR-4422	93.9997	NM_014415
ZBTB11	hsa-miR-4732-3p	93.2303	NM_014415
ZBTB11	hsa-miR-5197-5p	92.8103	NM_014415
ZBTB11	hsa-miR-6853-3p	91.9961	NM_014415
ZBTB11	hsa-miR-4666a-5p	90.7308	NM_014415
ZBTB11	hsa-miR-3121-3p	90.0125	NM_014415
ZBTB11	hsa-miR-520f-3p	88.7848	NM_014415
ZBTB11	hsa-miR-4677-3p	88.6583	NM_014415
ZBTB11	hsa-miR-9-3p	88.4293	NM_014415
ZBTB11	hsa-miR-4312	87.7973	NM_014415
ZBTB11	hsa-miR-551b-5p	86.7392	NM_014415
ZBTB11	hsa-miR-340-5p	86.633	NM_014415
ZBTB11	hsa-miR-1468-3p	85.3341	NM_014415
ZBTB11	hsa-miR-513b-3p	84.8803	NM_014415
ZBTB11	hsa-miR-4775	82.6701	NM_014415
ZBTB11	hsa-miR-577	81.9649	NM_014415
ZBTB11	hsa-miR-450b-5p	81.3983	NM_014415
ZBTB11	hsa-miR-5590-3p	80.8304	NM_014415
ZBTB11	hsa-miR-142-5p	80.8304	NM_014415
ZBTB11	hsa-miR-19a-3p	80.6516	NM_014415
ZBTB11	hsa-miR-19b-3p	80.6516	NM_014415
ZBTB11	hsa-miR-506-3p	80.0689	NM_014415
ZBTB11	hsa-miR-124-3p	80.0689	NM_014415
ZBTB11	hsa-miR-11401	80.0393	NM_014415

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Motifs and transcription factors (TFs) regulating ZBTB11

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZBTB11	metacluster_135.11	NR2C2 (directAnnotation).
ZBTB11	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ZBTB11	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ZBTB11	metacluster_7.13	ZFX (directAnnotation).
ZBTB11	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ZBTB11	cisbp__M00968	MTF2 (directAnnotation).
ZBTB11	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ZBTB11	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ZBTB11	cisbp__M00341	PAX6 (directAnnotation).
ZBTB11	metacluster_198.3	ZFP64 (directAnnotation).
ZBTB11	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ZBTB11	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ZBTB11	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ZBTB11	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ZBTB11	cisbp__M00788	ZFY (inferredBy_Orthology).
ZBTB11	metacluster_175.1	ZNF283 (directAnnotation).
ZBTB11	hdpi__ZNF304	ZNF304 (directAnnotation).
ZBTB11	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ZBTB11	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ZBTB11	transfac_pro__M01199	TRIM28 (directAnnotation).
ZBTB11	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ZBTB11	metacluster_151.2	ZNF23 (directAnnotation).
ZBTB11	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ZBTB11	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ZBTB11	transfac_pro__M03806	ZBTB7C (directAnnotation).
ZBTB11	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."