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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: YY1

Summary for YY1

Gene information	Gene symbol	YY1
	Ensembl ID	ENSG00000100811
	Entrez ID	7528
	Gene name	YY1 transcription factor
	Synonyms	DELTA\|INO80S\|NF-E1\|UCRBP\|YIN-YANG-1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: YY1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.281718	4.10e-27
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.353043	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.270441	3.91e-07
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.256987	0.00e+00

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Expression of YY1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to YY1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
YY1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating YY1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
YY1	hsa-miR-6501-3p	82.0335	NM_003403
YY1	hsa-miR-511-5p	81.9537	NM_003403
YY1	hsa-miR-130b-3p	81.6347	NM_003403
YY1	hsa-miR-130a-3p	81.6347	NM_003403
YY1	hsa-miR-516b-5p	81.1282	NM_003403
YY1	hsa-miR-7162-3p	81.0317	NM_003403
YY1	hsa-miR-4799-3p	80.2673	NM_003403
YY1	hsa-miR-5588-5p	80.2673	NM_003403
YY1	hsa-miR-4720-5p	80.2673	NM_003403

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Motifs and transcription factors (TFs) regulating YY1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
YY1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
YY1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
YY1	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
YY1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
YY1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
YY1	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
YY1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
YY1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
YY1	metacluster_3.14	WT1; WT1 (directAnnotation).
YY1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
YY1	cisbp__M07938	E2F1 (directAnnotation).
YY1	jaspar__MA0748.2	YY2 (directAnnotation).
YY1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
YY1	cisbp__M00788	ZFY (inferredBy_Orthology).
YY1	metacluster_7.13	ZFX (directAnnotation).
YY1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
YY1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
YY1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
YY1	hdpi__HIP2	UBE2K (directAnnotation).
YY1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
YY1	transfac_pro__M02913	SP140 (inferredBy_Orthology).
YY1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
YY1	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
YY1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
YY1	transfac_pro__M02898	SMAD3 (directAnnotation).
YY1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
YY1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
YY1	hdpi__TIMELESS	TIMELESS (directAnnotation).
YY1	transfac_pro__M04893	TAF1 (directAnnotation).
YY1	cisbp__M00249	WT1 (directAnnotation).
YY1	transfac_pro__M00430	E2F1 (directAnnotation).
YY1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
YY1	hdpi__ZNF304	ZNF304 (directAnnotation).
YY1	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
YY1	transfac_pro__M00938	E2F1 (directAnnotation).
YY1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
YY1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
YY1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
YY1	transfac_pro__M01122	ZNF219 (directAnnotation).
YY1	metacluster_151.2	ZNF23 (directAnnotation).
YY1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
YY1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
YY1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
YY1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
YY1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
YY1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
YY1	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
YY1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
YY1	taipale_tf_pairs__GCM1_ERG_RTRYGGGCGGAARKN_CAP	ERG; GCM1 (directAnnotation).
YY1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
YY1	metacluster_141.6	down	CD8+ T cells	GSE199333	post
YY1	metacluster_141.5	down	Malignant cells	GSE199333	pre

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."