Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: YTHDF3

Summary for YTHDF3

Gene information	Gene symbol	YTHDF3
	Ensembl ID	ENSG00000185728
	Entrez ID	253943
	Gene name	YTH N6-methyladenosine RNA binding protein 3
	Synonyms	FLJ31657
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: YTHDF3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.32683	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.414829	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.362284	7.08e-22

Top

Expression of YTHDF3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to YTHDF3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating YTHDF3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
YTHDF3	hsa-miR-4528	89.0003	NM_001277813
YTHDF3	hsa-miR-137-3p	88.9495	NM_001277813
YTHDF3	hsa-miR-302f	88.9411	NM_001277813
YTHDF3	hsa-miR-7702	88.8595	NM_001277813
YTHDF3	hsa-miR-888-5p	88.85	NM_001277813
YTHDF3	hsa-miR-153-5p	88.7984	NM_001277813
YTHDF3	hsa-miR-95-5p	88.7639	NM_001277813
YTHDF3	hsa-miR-548aj-5p	88.7534	NM_001277813
YTHDF3	hsa-miR-548x-5p	88.7534	NM_001277813
YTHDF3	hsa-miR-548f-5p	88.7534	NM_001277813
YTHDF3	hsa-miR-548g-5p	88.7534	NM_001277813
YTHDF3	hsa-miR-7853-5p	88.0324	NM_001277813
YTHDF3	hsa-miR-105-5p	88.0324	NM_001277813
YTHDF3	hsa-miR-4503	87.926	NM_001277813
YTHDF3	hsa-miR-513a-5p	87.8701	NM_001277813
YTHDF3	hsa-miR-582-5p	87.2299	NM_001277813
YTHDF3	hsa-miR-190b-5p	86.5913	NM_001277813
YTHDF3	hsa-miR-190a-5p	86.5913	NM_001277813
YTHDF3	hsa-miR-7162-3p	86.528	NM_001277813
YTHDF3	hsa-miR-3922-5p	86.0485	NM_001277813
YTHDF3	hsa-miR-6889-3p	85.8711	NM_001277813
YTHDF3	hsa-miR-3148	85.7329	NM_001277813
YTHDF3	hsa-miR-520e-5p	85.3998	NM_001277813
YTHDF3	hsa-miR-1251-3p	85.3209	NM_001277813
YTHDF3	hsa-miR-7-2-3p	85.2967	NM_001277813
YTHDF3	hsa-miR-7-1-3p	85.2967	NM_001277813
YTHDF3	hsa-miR-29b-3p	85.258	NM_001277813
YTHDF3	hsa-miR-29a-3p	85.258	NM_001277813
YTHDF3	hsa-miR-29c-3p	85.258	NM_001277813
YTHDF3	hsa-miR-3529-3p	85.2328	NM_001277813
YTHDF3	hsa-miR-579-3p	85.0885	NM_001277813
YTHDF3	hsa-miR-664b-3p	85.0885	NM_001277813
YTHDF3	hsa-miR-380-3p	84.5073	NM_001277813
YTHDF3	hsa-miR-1297	84.4544	NM_001277813
YTHDF3	hsa-miR-30a-3p	84.4474	NM_001277813
YTHDF3	hsa-miR-30e-3p	84.4474	NM_001277813
YTHDF3	hsa-miR-30d-3p	84.4474	NM_001277813
YTHDF3	hsa-miR-181d-5p	84.2697	NM_001277813
YTHDF3	hsa-miR-548bb-3p	84.2662	NM_001277813
YTHDF3	hsa-miR-548z	84.2662	NM_001277813
YTHDF3	hsa-miR-548d-3p	84.2662	NM_001277813
YTHDF3	hsa-miR-548h-3p	84.2662	NM_001277813
YTHDF3	hsa-miR-548ac	84.2662	NM_001277813
YTHDF3	hsa-miR-4762-5p	84.0721	NM_001277813
YTHDF3	hsa-miR-6513-3p	84.0702	NM_001277813
YTHDF3	hsa-miR-3974	83.9733	NM_001277813
YTHDF3	hsa-miR-4262	83.4173	NM_001277813
YTHDF3	hsa-miR-98-3p	83.1698	NM_001277813
YTHDF3	hsa-let-7b-3p	83.1698	NM_001277813
YTHDF3	hsa-let-7f-1-3p	83.1698	NM_001277813

Page: 1 2 3

Top

Motifs and transcription factors (TFs) regulating YTHDF3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
YTHDF3	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
YTHDF3	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
YTHDF3	transfac_pro__M04826	EP300 (directAnnotation).
YTHDF3	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
YTHDF3	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
YTHDF3	transfac_pro__M04866	HDAC2 (directAnnotation).
YTHDF3	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
YTHDF3	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
YTHDF3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
YTHDF3	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
YTHDF3	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
YTHDF3	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
YTHDF3	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
YTHDF3	jaspar__MA0748.2	YY2 (directAnnotation).
YTHDF3	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
YTHDF3	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
YTHDF3	transfac_pro__M04893	TAF1 (directAnnotation).
YTHDF3	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
YTHDF3	transfac_pro__M00514	ATF4 (directAnnotation).
YTHDF3	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
YTHDF3	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."