Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: YOD1

Summary for YOD1

Gene information	Gene symbol	YOD1
	Ensembl ID	ENSG00000180667
	Entrez ID	55432
	Gene name	YOD1 deubiquitinase
	Synonyms	DKFZp451J1719\|DUBA8\|OTUD2
	Gene type	protein_coding
	UniProtAcc	Q5VVQ6

Top

Dataset with differentially expressed gene: YOD1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	-0.267288	1.10e-02
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.29983	8.39e-30

Top

Expression of YOD1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to YOD1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating YOD1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
YOD1	hsa-miR-561-5p	93.0068	NM_001276320
YOD1	hsa-miR-20a-5p	92.7698	NM_001276320
YOD1	hsa-miR-106b-5p	92.7698	NM_001276320
YOD1	hsa-miR-8064	92.2645	NM_018566
YOD1	hsa-miR-140-5p	92.0146	NM_018566
YOD1	hsa-miR-9986	91.9117	NM_001276320
YOD1	hsa-miR-1294	91.9117	NM_001276320
YOD1	hsa-miR-12119	91.1831	NM_018566
YOD1	hsa-miR-217-5p	91.018	NM_018566
YOD1	hsa-miR-10527-5p	90.7679	NM_001276320
YOD1	hsa-miR-5590-3p	89.9056	NM_001276320
YOD1	hsa-miR-106a-5p	89.8663	NM_001276320
YOD1	hsa-miR-6739-3p	89.6132	NM_018566
YOD1	hsa-miR-526b-3p	89.6062	NM_001276320
YOD1	hsa-miR-519d-3p	89.4022	NM_001276320
YOD1	hsa-miR-17-5p	89.4022	NM_001276320
YOD1	hsa-miR-93-5p	89.4022	NM_001276320
YOD1	hsa-miR-20b-5p	89.4022	NM_001276320
YOD1	hsa-miR-383-5p	89.3336	NM_018566
YOD1	hsa-miR-551b-5p	88.2939	NM_018566
YOD1	hsa-miR-6807-3p	88.1355	NM_018566
YOD1	hsa-miR-7152-5p	87.9211	NM_018566
YOD1	hsa-miR-7159-3p	87.5368	NM_018566
YOD1	hsa-miR-520f-3p	87.2408	NM_001276320
YOD1	hsa-miR-142-5p	87.1602	NM_001276320
YOD1	hsa-miR-10523-5p	87.0332	NM_018566
YOD1	hsa-miR-4482-3p	87.0316	NM_018566
YOD1	hsa-miR-4262	87.0005	NM_001276320
YOD1	hsa-miR-6809-5p	86.882	NM_001276320
YOD1	hsa-miR-4316	86.8788	NM_001276320
YOD1	hsa-miR-670-5p	86.2312	NM_001276320
YOD1	hsa-miR-3609	86.0998	NM_001276320
YOD1	hsa-miR-548ah-5p	86.0998	NM_001276320
YOD1	hsa-miR-545-5p	85.6867	NM_018566
YOD1	hsa-miR-548c-3p	85.524	NM_018566
YOD1	hsa-miR-340-5p	85.0893	NM_001276320
YOD1	hsa-miR-4460	84.9308	NM_018566
YOD1	hsa-miR-4677-5p	84.8037	NM_018566
YOD1	hsa-miR-95-5p	84.7762	NM_018566
YOD1	hsa-miR-9851-3p	84.6337	NM_001276320
YOD1	hsa-miR-4302	84.5697	NM_018566
YOD1	hsa-miR-20a-3p	84.4794	NM_018566
YOD1	hsa-miR-4530	84.4674	NM_018566
YOD1	hsa-miR-5579-3p	83.9205	NM_001276320
YOD1	hsa-miR-664b-3p	83.5879	NM_018566
YOD1	hsa-miR-579-3p	83.5879	NM_018566
YOD1	hsa-miR-9851-5p	83.274	NM_018566
YOD1	hsa-miR-4781-3p	82.854	NM_018566
YOD1	hsa-miR-219b-3p	82.6375	NM_018566
YOD1	hsa-miR-1305	82.5881	NM_001276320

Page: 1 2 3

Top

Motifs and transcription factors (TFs) regulating YOD1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
YOD1	transfac_pro__M05392	SCRT2 (inferredBy_Orthology).
YOD1	transfac_pro__M07392	PITX3 (directAnnotation).
YOD1	transfac_pro__M06292	ZNF766 (directAnnotation).
YOD1	hocomoco__OTX1_HUMAN.H11MO.0.D	OTX1 (directAnnotation).
YOD1	transfac_pro__M06798	PRDM15 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."