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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: XRN1

Summary for XRN1

Gene information	Gene symbol	XRN1
	Ensembl ID	ENSG00000114127
	Entrez ID	54464
	Gene name	5'-3' exoribonuclease 1
	Synonyms	SEP1
	Gene type	protein_coding
	UniProtAcc	Q8IZH2

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Dataset with differentially expressed gene: XRN1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.274875	1.85e-07

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Expression of XRN1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to XRN1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating XRN1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
XRN1	hsa-miR-190a-5p	89.6891	NM_001282857
XRN1	hsa-miR-3606-3p	89.6859	NM_001282857
XRN1	hsa-miR-4458	89.611	NM_001282857
XRN1	hsa-let-7d-5p	89.611	NM_001282857
XRN1	hsa-miR-3156-5p	89.528	NM_001282857
XRN1	hsa-miR-4698	89.1085	NM_001282857
XRN1	hsa-miR-500a-5p	88.8268	NM_001282859
XRN1	hsa-miR-888-5p	88.743	NM_001282857
XRN1	hsa-miR-4262	88.4277	NM_001282857
XRN1	hsa-miR-466	88.2748	NM_001282857
XRN1	hsa-miR-670-3p	87.8149	NM_001282859
XRN1	hsa-miR-8063	87.789	NM_001282859
XRN1	hsa-miR-153-5p	87.7216	NM_001282859
XRN1	hsa-miR-190b-5p	87.6527	NM_001282857
XRN1	hsa-miR-3978	87.2039	NM_001282857
XRN1	hsa-miR-10b-5p	87.0992	NM_001282857
XRN1	hsa-miR-10a-5p	87.0992	NM_001282857
XRN1	hsa-miR-3662	87.067	NM_001282857
XRN1	hsa-miR-1252-3p	87.0386	NM_001282857
XRN1	hsa-miR-6829-3p	86.5345	NM_001282857
XRN1	hsa-miR-6791-3p	86.5345	NM_001282857
XRN1	hsa-miR-3166	86.5159	NM_001282857
XRN1	hsa-miR-372-5p	86.359	NM_001282857
XRN1	hsa-miR-4760-5p	86.2354	NM_001282859
XRN1	hsa-miR-548c-3p	86.1624	NM_001282857
XRN1	hsa-miR-551b-5p	85.4856	NM_001282857
XRN1	hsa-miR-5195-3p	85.4293	NM_001282857
XRN1	hsa-miR-145-5p	85.4293	NM_001282857
XRN1	hsa-miR-6504-3p	84.9718	NM_001282857
XRN1	hsa-miR-10399-5p	84.9718	NM_001282857
XRN1	hsa-miR-10395-5p	84.8614	NM_001282857
XRN1	hsa-miR-539-5p	84.3953	NM_001282857
XRN1	hsa-miR-8067	83.9245	NM_001282857
XRN1	hsa-miR-4517	83.6452	NM_001282859
XRN1	hsa-miR-3192-5p	83.6142	NM_001282859
XRN1	hsa-miR-548n	83.5411	NM_001282857
XRN1	hsa-miR-6828-5p	83.3674	NM_001282857
XRN1	hsa-miR-499a-5p	83.2328	NM_001282857
XRN1	hsa-miR-4760-3p	82.8247	NM_001282859
XRN1	hsa-miR-6508-5p	82.7725	NM_001282857
XRN1	hsa-miR-421	82.7312	NM_001282857
XRN1	hsa-miR-4668-5p	81.2377	NM_001282857
XRN1	hsa-miR-186-5p	81.2331	NM_001282857
XRN1	hsa-miR-3658	81.1214	NM_001282857
XRN1	hsa-miR-942-5p	80.986	NM_001282857
XRN1	hsa-miR-32-3p	80.9421	NM_001282857
XRN1	hsa-miR-4531	80.7239	NM_001282857
XRN1	hsa-miR-7856-5p	80.6731	NM_001282859
XRN1	hsa-miR-8061	80.5985	NM_001282859
XRN1	hsa-miR-7154-5p	80.4415	NM_001282859

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Motifs and transcription factors (TFs) regulating XRN1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
XRN1	hdpi__TIMELESS	TIMELESS (directAnnotation).
XRN1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
XRN1	metacluster_181.1	EGR2; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLIS1; ZBTB7A; ZBTB7A; ZBTB7B; ZBTB7B; ZBTB7B; ZBTB7C; ZFP2; ZIC1; ZIC1; ZIC1; ZIC2; ZIC2; ZIC3; ZNF449; ZNF71 (directAnnotation). GLI1; GLI1; GLI2; GLI2; GLI2; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; VPS72; ZIC3; ZXDA; ZXDA; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."