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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: WWTR1

Summary for WWTR1

Gene information	Gene symbol	WWTR1
	Ensembl ID	ENSG00000018408
	Entrez ID	25937
	Gene name	WW domain containing transcription regulator 1
	Synonyms	DKFZp586I1419\|TAZ
	Gene type	protein_coding
	UniProtAcc	Q9GZV5

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Dataset with differentially expressed gene: WWTR1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.28365	1.49e-29
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.32051	4.03e-14
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.968201	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.457237	0.00e+00

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Expression of WWTR1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to WWTR1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating WWTR1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
WWTR1	hsa-miR-6871-3p	80.8106	NM_001168278
WWTR1	hsa-miR-511-5p	80.5688	NM_015472
WWTR1	hsa-miR-3662	80.5565	NM_015472
WWTR1	hsa-miR-5572	80.439	NM_015472

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Motifs and transcription factors (TFs) regulating WWTR1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
WWTR1	transfac_pro__M07436	WT1 (directAnnotation).
WWTR1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
WWTR1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
WWTR1	transfac_pro__M02089	E2F3 (directAnnotation).
WWTR1	transfac_pro__M01122	ZNF219 (directAnnotation).
WWTR1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
WWTR1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
WWTR1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
WWTR1	transfac_pro__M08819	KLF2 (directAnnotation).
WWTR1	transfac_pro__M01175	ZBTB7B (directAnnotation).
WWTR1	transfac_pro__M01118	WT1 (directAnnotation).
WWTR1	swissregulon__hs__KLF6	KLF6 (directAnnotation).
WWTR1	transfac_pro__M01303	SP1 (directAnnotation).
WWTR1	transfac_pro__M04595	SALL2 (directAnnotation).
WWTR1	transfac_pro__M01837	KLF11 (directAnnotation).
WWTR1	transfac_pro__M00716	ZBTB14 (directAnnotation).
WWTR1	metacluster_133.2	CPSF4; CPSF4; E2F4; FOXO3; KLF13; KLF15; KLF17; KLF5; MAZ; MAZ; MAZ; MZF1; PATZ1; PATZ1; PATZ1; PATZ1; PLAG1; PRDM9; SP4; VEZF1; WT1; ZBTB17; ZBTB7A; ZBTB7A; ZBTB7B; ZNF148; ZNF148; ZNF148; ZNF148; ZNF180; ZNF180; ZNF202; ZNF219; ZNF219; ZNF263; ZNF263; ZNF28; ZNF281; ZNF281; ZNF281; ZNF281; ZNF281; ZNF383; ZNF398; ZNF398; ZNF444; ZNF444; ZNF467; ZNF543; ZNF543; ZNF641; ZNF692; ZNF737; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF880; ZNF880 (directAnnotation). MAZ; PLAG1; PLAGL1; SP1; SP5; SP5; ZBTB17; ZNF281; ZNF281; ZNF281; ZNF641; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
WWTR1	transfac_pro__M07397	ZNF148 (directAnnotation).
WWTR1	transfac_pro__M00807	EGR1; EGR2; EGR3 (directAnnotation).
WWTR1	transfac_pro__M01104	OVOL2 (directAnnotation).
WWTR1	transfac_pro__M06520	ZNF721 (directAnnotation).
WWTR1	transfac_pro__M00986	CHURC1 (directAnnotation).
WWTR1	taipale_tf_pairs__MGA_DLX2_SYAATTANWGGTGYGA_CAP	DLX2; MGA (directAnnotation).
WWTR1	metacluster_135.11	NR2C2 (directAnnotation).
WWTR1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
WWTR1	metacluster_7.13	ZFX (directAnnotation).
WWTR1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
WWTR1	cisbp__M00968	MTF2 (directAnnotation).
WWTR1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
WWTR1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
WWTR1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
WWTR1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
WWTR1	cisbp__M00788	ZFY (inferredBy_Orthology).
WWTR1	hdpi__ZNF304	ZNF304 (directAnnotation).
WWTR1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
WWTR1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
WWTR1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
WWTR1	metacluster_151.2	ZNF23 (directAnnotation).
WWTR1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
WWTR1	transfac_pro__M03806	ZBTB7C (directAnnotation).
WWTR1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
WWTR1	transfac_pro__M01253	CNOT3 (directAnnotation).
WWTR1	transfac_pro__M04817	ZBTB33 (directAnnotation).
WWTR1	transfac_pro__M05712	ZNF134 (directAnnotation).
WWTR1	cisbp__M07938	E2F1 (directAnnotation).
WWTR1	swissregulon__hs__ETV6	ETV6 (directAnnotation).
WWTR1	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
WWTR1	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
WWTR1	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
WWTR1	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."