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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: VEGFA

Summary for VEGFA

Gene information	Gene symbol	VEGFA
	Ensembl ID	ENSG00000112715
	Entrez ID	7422
	Gene name	vascular endothelial growth factor A
	Synonyms	VEGF\|VEGF-A\|VPF
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: VEGFA

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.507	1.35e-14
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.711342	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.96329	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.902864	3.15e-18
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.967314	3.21e-23
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	-0.282999	3.78e-22
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	1.05516	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-1.00802	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.45355	4.78e-24

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Expression of VEGFA in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to VEGFA

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
VEGFA	Mono/Macro	CPI-SS043E22BF5	VEGFA_NRP1	VEGFA	NRP1	False	Mono/Macro	Fibroblasts	GSE189460	pre	resistant
VEGFA	Mono/Macro	CPI-SS043E22BF5	VEGFA_NRP1	VEGFA	NRP1	False	Mono/Macro	pDCs	GSE189460	pre	resistant
VEGFA	Mono/Macro	CPI-SS046F8AD8B	VEGFA_NRP2	VEGFA	NRP2	False	Mono/Macro	Fibroblasts	GSE189460	pre	sensitive
VEGFA	Mono/Macro	CPI-SS043E22BF5	VEGFA_NRP1	VEGFA	NRP1	False	Mono/Macro	Fibroblasts	GSE189460	pre	sensitive
VEGFA	Mono/Macro	CPI-SS043E22BF5	VEGFA_NRP1	VEGFA	NRP1	False	Mono/Macro	pDCs	GSE189460	pre	sensitive
VEGFA	Mono/Macro	CPI-SS046F8AD8B	VEGFA_NRP2	VEGFA	NRP2	False	Fibroblasts	Mono/Macro	GSE207422_Sin	post	resistant
VEGFA	Mono/Macro	CPI-SS043E22BF5	VEGFA_NRP1	VEGFA	NRP1	False	Fibroblasts	Mono/Macro	GSE207422_Sin	post	resistant
VEGFA	Mono/Macro	CPI-SS046F8AD8B	VEGFA_NRP2	VEGFA	NRP2	False	Malignant cells	Mono/Macro	GSE207422_Sin	post	resistant
VEGFA	Mono/Macro	CPI-SS043E22BF5	VEGFA_NRP1	VEGFA	NRP1	False	Malignant cells	Mono/Macro	GSE207422_Sin	post	resistant
VEGFA	Mono/Macro	CPI-SS046F8AD8B	VEGFA_NRP2	VEGFA	NRP2	False	Mast cells	Mono/Macro	GSE207422_Sin	post	resistant
VEGFA	Mono/Macro	CPI-SS043E22BF5	VEGFA_NRP1	VEGFA	NRP1	False	Mast cells	Mono/Macro	GSE207422_Sin	post	resistant
VEGFA	Mono/Macro	CPI-SS046F8AD8B	VEGFA_NRP2	VEGFA	NRP2	False	Mono/Macro	Fibroblasts	GSE207422_Sin	post	resistant
VEGFA	Mono/Macro	CPI-SS043E22BF5	VEGFA_NRP1	VEGFA	NRP1	False	Mono/Macro	Fibroblasts	GSE207422_Sin	post	resistant
VEGFA	Mono/Macro	CPI-SS046F8AD8B	VEGFA_NRP2	VEGFA	NRP2	False	Mono/Macro	Malignant cells	GSE207422_Sin	post	resistant
VEGFA	Mono/Macro	CPI-SS046F8AD8B	VEGFA_NRP2	VEGFA	NRP2	False	Mono/Macro	Mono/Macro	GSE207422_Sin	post	resistant
VEGFA	Mono/Macro	CPI-SS043E22BF5	VEGFA_NRP1	VEGFA	NRP1	False	Mono/Macro	Mono/Macro	GSE207422_Sin	post	resistant
VEGFA	Mono/Macro	CPI-SS043E22BF5	VEGFA_NRP1	VEGFA	NRP1	False	Mono/Macro	pDCs	GSE207422_Sin	post	resistant
VEGFA	Mono/Macro	CPI-SS046F8AD8B	VEGFA_NRP2	VEGFA	NRP2	False	Neutrophils	Mono/Macro	GSE207422_Sin	post	resistant
VEGFA	Mono/Macro	CPI-SS043E22BF5	VEGFA_NRP1	VEGFA	NRP1	False	Neutrophils	Mono/Macro	GSE207422_Sin	post	resistant
VEGFA	Mono/Macro	CPI-SS043E22BF5	VEGFA_NRP1	VEGFA	NRP1	False	Malignant cells	Mono/Macro	GSE207422_Sin	post	sensitive
VEGFA	Mono/Macro	CPI-SS046F8AD8B	VEGFA_NRP2	VEGFA	NRP2	False	Malignant cells	Mono/Macro	GSE207422_Sin	post	sensitive
VEGFA	Mono/Macro	CPI-SS043E22BF5	VEGFA_NRP1	VEGFA	NRP1	False	Mast cells	Mono/Macro	GSE207422_Sin	post	sensitive
VEGFA	Mono/Macro	CPI-SS046F8AD8B	VEGFA_NRP2	VEGFA	NRP2	False	Mast cells	Mono/Macro	GSE207422_Sin	post	sensitive
VEGFA	Mono/Macro	CPI-SS046F8AD8B	VEGFA_NRP2	VEGFA	NRP2	False	Fibroblasts	Mono/Macro	GSE207422_Tor	post	resistant
VEGFA	Mono/Macro	CPI-SS043E22BF5	VEGFA_NRP1	VEGFA	NRP1	False	Fibroblasts	Mono/Macro	GSE207422_Tor	post	resistant
VEGFA	Mono/Macro	CPI-SS046F8AD8B	VEGFA_NRP2	VEGFA	NRP2	False	Malignant cells	Mono/Macro	GSE207422_Tor	post	resistant
VEGFA	Mono/Macro	CPI-SS043E22BF5	VEGFA_NRP1	VEGFA	NRP1	False	Malignant cells	Mono/Macro	GSE207422_Tor	post	resistant
VEGFA	Mono/Macro	CPI-SS046F8AD8B	VEGFA_NRP2	VEGFA	NRP2	False	Mast cells	Mono/Macro	GSE207422_Tor	post	resistant
VEGFA	Mono/Macro	CPI-SS043E22BF5	VEGFA_NRP1	VEGFA	NRP1	False	Mast cells	Mono/Macro	GSE207422_Tor	post	resistant
VEGFA	Mono/Macro	CPI-SS0C03F7CDC	VEGFA_KDR	VEGFA	KDR	False	Mono/Macro	Endothelial cells	GSE207422_Tor	post	resistant
VEGFA	Mono/Macro	CPI-SS0B9B3870A	VEGFA_FLT1	VEGFA	FLT1	False	Mono/Macro	Endothelial cells	GSE207422_Tor	post	resistant
VEGFA	Mono/Macro	CPI-SC0AFC650CD	VEGFA_FLT1_complex	VEGFA	NA	False	Mono/Macro	Endothelial cells	GSE207422_Tor	post	resistant
VEGFA	Mono/Macro	CPI-SS046F8AD8B	VEGFA_NRP2	VEGFA	NRP2	False	Mono/Macro	Endothelial cells	GSE207422_Tor	post	resistant
VEGFA	Mono/Macro	CPI-SS043E22BF5	VEGFA_NRP1	VEGFA	NRP1	False	Mono/Macro	Endothelial cells	GSE207422_Tor	post	resistant
VEGFA	Mono/Macro	CPI-SS046F8AD8B	VEGFA_NRP2	VEGFA	NRP2	False	Mono/Macro	Fibroblasts	GSE207422_Tor	post	resistant
VEGFA	Mono/Macro	CPI-SS043E22BF5	VEGFA_NRP1	VEGFA	NRP1	False	Mono/Macro	Fibroblasts	GSE207422_Tor	post	resistant
VEGFA	Mono/Macro	CPI-SS046F8AD8B	VEGFA_NRP2	VEGFA	NRP2	False	Mono/Macro	Malignant cells	GSE207422_Tor	post	resistant
VEGFA	Mono/Macro	CPI-SS046F8AD8B	VEGFA_NRP2	VEGFA	NRP2	False	Mono/Macro	Mono/Macro	GSE207422_Tor	post	resistant
VEGFA	Mono/Macro	CPI-SS043E22BF5	VEGFA_NRP1	VEGFA	NRP1	False	Mono/Macro	Mono/Macro	GSE207422_Tor	post	resistant
VEGFA	Mono/Macro	CPI-SS043E22BF5	VEGFA_NRP1	VEGFA	NRP1	False	Mono/Macro	pDCs	GSE207422_Tor	post	resistant
VEGFA	Mono/Macro	CPI-SS046F8AD8B	VEGFA_NRP2	VEGFA	NRP2	False	Malignant cells	Mono/Macro	GSE207422_Tor	post	sensitive
VEGFA	Mono/Macro	CPI-SS043E22BF5	VEGFA_NRP1	VEGFA	NRP1	False	Malignant cells	Mono/Macro	GSE207422_Tor	post	sensitive
VEGFA	Mono/Macro	CPI-SS046F8AD8B	VEGFA_NRP2	VEGFA	NRP2	False	Mast cells	Mono/Macro	GSE207422_Tor	post	sensitive
VEGFA	Mono/Macro	CPI-SS043E22BF5	VEGFA_NRP1	VEGFA	NRP1	False	Mast cells	Mono/Macro	GSE207422_Tor	post	sensitive

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
VEGFA	Regulation by the Disease Microenvironment
VEGFA	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating VEGFA

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
VEGFA	hsa-miR-4648	87.7005	NM_001171629
VEGFA	hsa-miR-6748-5p	87.5359	NM_001171629
VEGFA	hsa-miR-297	87.4523	NM_001171629
VEGFA	hsa-miR-361-5p	87.4068	NM_001171629
VEGFA	hsa-miR-1299	86.8892	NM_001171627
VEGFA	hsa-miR-4270	86.7622	NM_001171629
VEGFA	hsa-miR-6844	86.563	NM_001171629
VEGFA	hsa-miR-5580-3p	86.3884	NM_001171627
VEGFA	hsa-miR-4441	85.7823	NM_001171629
VEGFA	hsa-miR-4766-3p	84.9609	NM_001171627
VEGFA	hsa-miR-6083	84.5576	NM_001171629
VEGFA	hsa-miR-186-5p	84.465	NM_001171629
VEGFA	hsa-miR-516b-5p	83.9322	NM_001171627
VEGFA	hsa-miR-503-5p	83.5032	NM_001171627
VEGFA	hsa-miR-6501-5p	81.3695	NM_001171629
VEGFA	hsa-miR-3618	80.9051	NM_001171627
VEGFA	hsa-miR-140-5p	80.5981	NM_001171627
VEGFA	hsa-miR-646	80.1233	NM_001171627

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Motifs and transcription factors (TFs) regulating VEGFA

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
VEGFA	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
VEGFA	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
VEGFA	transfac_pro__M06213	ZNF267 (directAnnotation).
VEGFA	transfac_pro__M05788	ZNF569 (inferredBy_Orthology).
VEGFA	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
VEGFA	jaspar__MA1125.1	ZNF384 (directAnnotation).
VEGFA	metacluster_32.24	ZNF287 (directAnnotation).
VEGFA	metacluster_22.39	NFE2L2 (directAnnotation).
VEGFA	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
VEGFA	tfdimers__MD00069	IKZF1; PDX1 (directAnnotation).
VEGFA	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
VEGFA	transfac_pro__M01973	PLAG1 (directAnnotation).
VEGFA	metacluster_143.13	ZBTB7A (directAnnotation).
VEGFA	transfac_pro__M07260	IKZF1 (directAnnotation).
VEGFA	transfac_pro__M01835	KLF4 (directAnnotation).
VEGFA	hocomoco__PATZ1_HUMAN.H11MO.1.C	PATZ1 (directAnnotation).
VEGFA	swissregulon__hs__MTA3	MTA3 (directAnnotation).
VEGFA	nitta__CG18619_TCGAAG20NGA_KH_RTGACGTCAT_m1_c3u	CREBL2 (inferredBy_Orthology).
VEGFA	metacluster_168.4	ZNF652 (directAnnotation).
VEGFA	transfac_pro__M06550	ZNF519 (directAnnotation).
VEGFA	kznf__ZNF614_Imbeault2017_RP_ChIP-seq	ZNF614 (directAnnotation).
VEGFA	swissregulon__hs__FOXD3	FOXD3 (directAnnotation).
VEGFA	metacluster_172.22	E4F1 (inferredBy_Orthology).
VEGFA	transfac_pro__M06388	ZNF677 (directAnnotation).
VEGFA	tfdimers__MD00299	ETS1; SRY (directAnnotation).
VEGFA	transfac_pro__M06104	ZNF16 (directAnnotation).
VEGFA	tfdimers__MD00075	FOXO4; NANOG (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
VEGFA	"ABT-510"	DB05434	small molecule
VEGFA	"Aflibercept"	DB08885	biotech
VEGFA	"Bevacizumab"	DB00112	biotech
VEGFA	"Bevasiranib"	DB06642	biotech
VEGFA	"Brolucizumab"	DB14864	biotech
VEGFA	"Carvedilol"	DB01136	small molecule
VEGFA	"Chondroitin sulfate"	DB09301	small molecule
VEGFA	"Dalteparin"	DB06779	small molecule
VEGFA	"Denibulin"	DB05932	small molecule
VEGFA	"Faricimab"	DB15303	biotech
VEGFA	"Foreskin keratinocyte (neonatal)"	DB10772	biotech
VEGFA	"Gliclazide"	DB01120	small molecule
VEGFA	"Minocycline"	DB01017	small molecule
VEGFA	"Pegaptanib"	DB04895	biotech
VEGFA	"Pidolic acid"	DB03088	small molecule
VEGFA	"Ranibizumab"	DB01270	biotech
VEGFA	"SNS-032"	DB05969	small molecule
VEGFA	"Vandetanib"	DB05294	small molecule
VEGFA	"Vanucizumab"	DB12317	biotech
VEGFA	"Veglin"	DB05890	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."