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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: VAPB

Summary for VAPB

Gene information	Gene symbol	VAPB
	Ensembl ID	ENSG00000124164
	Entrez ID	9217
	Gene name	VAMP associated protein B and C
	Synonyms	ALS8\|VAP-B\|VAP-C
	Gene type	protein_coding
	UniProtAcc	O95292

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Dataset with differentially expressed gene: VAPB

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.24471	7.94e-15
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.268621	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.335584	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.429692	0.00e+00

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Expression of VAPB in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to VAPB

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating VAPB

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
VAPB	hsa-miR-548v	82.2564	NM_001195677
VAPB	hsa-miR-6814-5p	82.1245	NM_001195677
VAPB	hsa-miR-548an	82.0845	NM_001195677
VAPB	hsa-miR-623	81.6329	NM_001195677
VAPB	hsa-miR-4267	81.5771	NM_004738
VAPB	hsa-miR-12132	81.5246	NM_001195677
VAPB	hsa-miR-6832-3p	81.5239	NM_004738
VAPB	hsa-miR-5088-5p	81.3992	NM_004738
VAPB	hsa-miR-31-5p	81.3496	NM_001195677
VAPB	hsa-miR-4452	81.1898	NM_004738
VAPB	hsa-miR-5584-5p	81.0851	NM_004738
VAPB	hsa-miR-10523-5p	80.8711	NM_004738
VAPB	hsa-miR-27a-3p	80.4166	NM_001195677
VAPB	hsa-miR-9985	80.4166	NM_001195677
VAPB	hsa-miR-27b-3p	80.4166	NM_001195677
VAPB	hsa-miR-4427	80.4076	NM_004738
VAPB	hsa-miR-892c-5p	80.0263	NM_004738

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Motifs and transcription factors (TFs) regulating VAPB

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
VAPB	metacluster_7.13	ZFX (directAnnotation).
VAPB	cisbp__M01863	ZNF711 (inferredBy_Orthology).
VAPB	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
VAPB	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
VAPB	metacluster_151.2	ZNF23 (directAnnotation).
VAPB	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
VAPB	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
VAPB	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
VAPB	metacluster_182.10	ZFX (directAnnotation).
VAPB	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
VAPB	jaspar__MA0079.5	SP1 (directAnnotation).
VAPB	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
VAPB	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
VAPB	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
VAPB	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
VAPB	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
VAPB	metacluster_3.14	WT1; WT1 (directAnnotation).
VAPB	cisbp__M07938	E2F1 (directAnnotation).
VAPB	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
VAPB	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
VAPB	transfac_pro__M07397	ZNF148 (directAnnotation).
VAPB	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
VAPB	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
VAPB	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
VAPB	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
VAPB	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
VAPB	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
VAPB	tfdimers__MD00151	CHURC1 (directAnnotation).
VAPB	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
VAPB	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
VAPB	transfac_pro__M01303	SP1 (directAnnotation).
VAPB	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
VAPB	swissregulon__hs__CHD1	CHD1 (directAnnotation).
VAPB	transfac_pro__M02090	E2F4 (directAnnotation).
VAPB	transfac_pro__M01714	KLF15 (directAnnotation).
VAPB	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
VAPB	jaspar__MA1122.1	TFDP1 (directAnnotation).
VAPB	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
VAPB	transfac_pro__M02089	E2F3 (directAnnotation).
VAPB	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
VAPB	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
VAPB	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).
VAPB	transfac_pro__M07436	WT1 (directAnnotation).
VAPB	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
VAPB	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
VAPB	transfac_pro__M02898	SMAD3 (directAnnotation).
VAPB	transfac_pro__M04617	ZBTB7A (directAnnotation).
VAPB	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
VAPB	hdpi__HIP2	UBE2K (directAnnotation).
VAPB	transfac_pro__M04893	TAF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."