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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: USP9X

Summary for USP9X

Gene information	Gene symbol	USP9X
	Ensembl ID	ENSG00000124486
	Entrez ID	8239
	Gene name	ubiquitin specific peptidase 9 X-linked
	Synonyms	DFFRX\|FAF\|MRX99
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: USP9X

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.481224	1.12e-44
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.278287	3.43e-06
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.285594	2.48e-07
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.263369	4.52e-27
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.549855	0.00e+00

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Expression of USP9X in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to USP9X

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating USP9X

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
USP9X	hsa-miR-10394-5p	86.532	NM_001039590
USP9X	hsa-miR-622	86.2819	NM_001039590
USP9X	hsa-miR-499b-3p	86.0815	NM_001039590
USP9X	hsa-miR-499a-3p	86.0815	NM_001039590
USP9X	hsa-miR-31-3p	85.775	NM_001039590
USP9X	hsa-miR-12120	85.7322	NM_001039590
USP9X	hsa-miR-3688-5p	85.6591	NM_001039590
USP9X	hsa-miR-4720-3p	85.3626	NM_001039590
USP9X	hsa-miR-507	85.217	NM_001039590
USP9X	hsa-miR-9983-3p	84.5797	NM_001039590
USP9X	hsa-miR-129-5p	84.5704	NM_001039590
USP9X	hsa-miR-1276	84.0888	NM_001039590
USP9X	hsa-miR-4741	84.0377	NM_001039590
USP9X	hsa-miR-6076	83.8287	NM_001039590
USP9X	hsa-miR-3941	83.7854	NM_001039590
USP9X	hsa-miR-4675	83.6552	NM_001039590
USP9X	hsa-miR-557	83.2084	NM_001039590
USP9X	hsa-miR-4662a-5p	82.9582	NM_001039590
USP9X	hsa-miR-6772-5p	82.5759	NM_001039590
USP9X	hsa-miR-6849-3p	82.5511	NM_001039590
USP9X	hsa-miR-7843-3p	82.4686	NM_001039590
USP9X	hsa-miR-6505-5p	82.3953	NM_001039590
USP9X	hsa-miR-4799-5p	82.3651	NM_001039590
USP9X	hsa-miR-6515-5p	82.2123	NM_001039590
USP9X	hsa-miR-8084	81.4092	NM_001039590
USP9X	hsa-miR-6796-3p	81.0174	NM_001039590
USP9X	hsa-miR-3148	80.9213	NM_001039590
USP9X	hsa-miR-155-5p	80.8598	NM_001039590
USP9X	hsa-miR-450b-5p	80.8365	NM_001039590
USP9X	hsa-miR-3692-3p	80.8133	NM_001039590
USP9X	hsa-miR-670-3p	80.4442	NM_001039590
USP9X	hsa-miR-5696	80.443	NM_001039590
USP9X	hsa-miR-144-3p	80.1347	NM_001039590

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Motifs and transcription factors (TFs) regulating USP9X

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
USP9X	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
USP9X	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
USP9X	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
USP9X	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
USP9X	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
USP9X	hdpi__ETV4	ETV4 (directAnnotation).
USP9X	cisbp__M02645	ETS1 (directAnnotation).
USP9X	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
USP9X	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
USP9X	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
USP9X	jaspar__MA1483.2	ELF2 (directAnnotation).
USP9X	cisbp__M00808	MYPOP (inferredBy_Orthology).
USP9X	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
USP9X	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
USP9X	cisbp__M08198	ELF1 (directAnnotation).
USP9X	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
USP9X	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
USP9X	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
USP9X	metacluster_111.5	E4F1; E4F1 (directAnnotation).
USP9X	jaspar__MA1957.1	ELK1 (directAnnotation).
USP9X	metacluster_135.11	NR2C2 (directAnnotation).
USP9X	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
USP9X	tfdimers__MD00038	TFAP2C (directAnnotation).
USP9X	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
USP9X	metacluster_7.13	ZFX (directAnnotation).
USP9X	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
USP9X	cisbp__M00968	MTF2 (directAnnotation).
USP9X	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
USP9X	metacluster_160.20	JUND; PRDM15 (directAnnotation).
USP9X	cisbp__M00341	PAX6 (directAnnotation).
USP9X	metacluster_198.3	ZFP64 (directAnnotation).
USP9X	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
USP9X	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
USP9X	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
USP9X	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
USP9X	cisbp__M00788	ZFY (inferredBy_Orthology).
USP9X	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
USP9X	metacluster_175.1	ZNF283 (directAnnotation).
USP9X	hdpi__ZNF304	ZNF304 (directAnnotation).
USP9X	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
USP9X	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
USP9X	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
USP9X	transfac_pro__M01199	TRIM28 (directAnnotation).
USP9X	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
USP9X	metacluster_151.2	ZNF23 (directAnnotation).
USP9X	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
USP9X	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
USP9X	transfac_pro__M03806	ZBTB7C (directAnnotation).
USP9X	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
USP9X	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."