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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: USP38

Summary for USP38

Gene information	Gene symbol	USP38
	Ensembl ID	ENSG00000170185
	Entrez ID	84640
	Gene name	ubiquitin specific peptidase 38
	Synonyms	HP43.8KD\|KIAA1891
	Gene type	protein_coding
	UniProtAcc	Q8NB14

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Dataset with differentially expressed gene: USP38

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.643374	0.00e+00

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Expression of USP38 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to USP38

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating USP38

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
USP38	hsa-miR-485-5p	85.4261	NM_001290325
USP38	hsa-miR-548as-3p	85.1851	NM_001290326
USP38	hsa-miR-205-3p	85.1538	NM_001290325
USP38	hsa-miR-607	85.0879	NM_032557
USP38	hsa-miR-6881-5p	85.0538	NM_001290326
USP38	hsa-miR-664b-3p	84.9577	NM_001290326
USP38	hsa-miR-579-3p	84.9577	NM_001290326
USP38	hsa-miR-548x-3p	84.9429	NM_001290326
USP38	hsa-miR-548aj-3p	84.9429	NM_001290326
USP38	hsa-miR-212-5p	84.9224	NM_001290325
USP38	hsa-miR-548bb-3p	84.8088	NM_001290326
USP38	hsa-miR-548z	84.8088	NM_001290326
USP38	hsa-miR-548h-3p	84.8088	NM_001290326
USP38	hsa-miR-4708-3p	84.7286	NM_032557
USP38	hsa-miR-5582-5p	84.4565	NM_032557
USP38	hsa-miR-548ap-3p	84.42	NM_001290326
USP38	hsa-miR-548t-3p	84.42	NM_001290326
USP38	hsa-miR-548aa	84.42	NM_001290326
USP38	hsa-miR-1226-5p	84.3755	NM_001290325
USP38	hsa-miR-4668-3p	84.2468	NM_001290326
USP38	hsa-miR-548l	83.9968	NM_001290325
USP38	hsa-miR-122b-5p	83.8464	NM_001290325
USP38	hsa-miR-4698	83.8179	NM_032557
USP38	hsa-miR-4732-3p	83.7268	NM_032557
USP38	hsa-miR-125a-5p	83.5485	NM_032557
USP38	hsa-miR-125b-5p	83.5485	NM_032557
USP38	hsa-miR-4424	83.5336	NM_032557
USP38	hsa-miR-552-5p	83.383	NM_032557
USP38	hsa-miR-4426	83.2969	NM_001290326
USP38	hsa-miR-30d-3p	83.2314	NM_001290326
USP38	hsa-miR-30a-3p	83.2314	NM_001290326
USP38	hsa-miR-30e-3p	83.2314	NM_001290326
USP38	hsa-miR-409-3p	82.7755	NM_032557
USP38	hsa-miR-144-3p	82.7155	NM_001290326
USP38	hsa-miR-7156-3p	82.7141	NM_001290326
USP38	hsa-miR-4318	82.6378	NM_001290326
USP38	hsa-miR-618	82.5362	NM_001290326
USP38	hsa-miR-548d-3p	82.2415	NM_001290326
USP38	hsa-miR-548ac	82.2415	NM_001290326
USP38	hsa-miR-4668-5p	81.758	NM_001290326
USP38	hsa-miR-3059-5p	81.6388	NM_001290325
USP38	hsa-miR-670-5p	81.5925	NM_032557
USP38	hsa-miR-3682-5p	81.4882	NM_032557
USP38	hsa-miR-6871-5p	80.6579	NM_001290326
USP38	hsa-miR-302c-5p	80.3542	NM_001290326
USP38	hsa-miR-548j-3p	80.2893	NM_001290326
USP38	hsa-miR-548ah-3p	80.2893	NM_001290326
USP38	hsa-miR-548ae-3p	80.2893	NM_001290326
USP38	hsa-miR-548am-3p	80.2893	NM_001290326
USP38	hsa-miR-548aq-3p	80.2893	NM_001290326

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Motifs and transcription factors (TFs) regulating USP38

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
USP38	metacluster_135.11	NR2C2 (directAnnotation).
USP38	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
USP38	tfdimers__MD00038	TFAP2C (directAnnotation).
USP38	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
USP38	metacluster_7.13	ZFX (directAnnotation).
USP38	cisbp__M00968	MTF2 (directAnnotation).
USP38	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
USP38	metacluster_160.20	JUND; PRDM15 (directAnnotation).
USP38	cisbp__M00341	PAX6 (directAnnotation).
USP38	metacluster_198.3	ZFP64 (directAnnotation).
USP38	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
USP38	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
USP38	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
USP38	cisbp__M00788	ZFY (inferredBy_Orthology).
USP38	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
USP38	metacluster_175.1	ZNF283 (directAnnotation).
USP38	hdpi__ZNF304	ZNF304 (directAnnotation).
USP38	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
USP38	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
USP38	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
USP38	transfac_pro__M01199	TRIM28 (directAnnotation).
USP38	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
USP38	metacluster_151.2	ZNF23 (directAnnotation).
USP38	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
USP38	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
USP38	transfac_pro__M03806	ZBTB7C (directAnnotation).
USP38	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."