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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: USP15

Summary for USP15

Gene information	Gene symbol	USP15
	Ensembl ID	ENSG00000135655
	Entrez ID	9958
	Gene name	ubiquitin specific peptidase 15
	Synonyms	KIAA0529\|UNPH4
	Gene type	protein_coding
	UniProtAcc	Q9Y4E8

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Dataset with differentially expressed gene: USP15

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.311496	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.729025	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.292904	2.61e-07
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.25421	4.73e-26
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	0.311825	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.346517	6.60e-12
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.314893	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.340289	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.287221	6.80e-35
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.359593	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.491188	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.256163	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.395148	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.559735	0.00e+00

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Expression of USP15 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to USP15

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating USP15

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
USP15	hsa-miR-590-5p	85.776	NM_006313
USP15	hsa-miR-6807-3p	85.7013	NM_006313
USP15	hsa-miR-548x-3p	85.6691	NM_006313
USP15	hsa-miR-548aj-3p	85.6691	NM_006313
USP15	hsa-miR-26a-5p	85.6359	NM_001252078
USP15	hsa-miR-26b-5p	85.6359	NM_001252078
USP15	hsa-miR-525-5p	85.635	NM_006313
USP15	hsa-miR-520a-5p	85.635	NM_006313
USP15	hsa-miR-4722-5p	85.5793	NM_001252078
USP15	hsa-miR-4418	85.5764	NM_006313
USP15	hsa-miR-378a-5p	85.5601	NM_006313
USP15	hsa-miR-587	85.5063	NM_006313
USP15	hsa-miR-590-3p	85.4627	NM_001252079
USP15	hsa-miR-21-5p	84.626	NM_006313
USP15	hsa-miR-4526	83.8238	NM_001252079
USP15	hsa-miR-3660	83.8238	NM_001252079
USP15	hsa-miR-4482-3p	83.8138	NM_006313
USP15	hsa-miR-33a-3p	83.6418	NM_006313
USP15	hsa-miR-578	83.6166	NM_001252078
USP15	hsa-miR-345-5p	83.4958	NM_001252079
USP15	hsa-miR-302c-5p	83.3667	NM_006313
USP15	hsa-miR-4465	82.9417	NM_001252078
USP15	hsa-miR-4251	82.43	NM_001252078
USP15	hsa-miR-4262	82.3802	NM_001252078
USP15	hsa-miR-3166	82.2016	NM_001252079
USP15	hsa-miR-4775	82.1095	NM_001252079
USP15	hsa-miR-6864-3p	81.8151	NM_001252078
USP15	hsa-miR-3672	81.8151	NM_001252078
USP15	hsa-miR-548ah-3p	81.6885	NM_006313
USP15	hsa-miR-548j-3p	81.6885	NM_006313
USP15	hsa-miR-548aq-3p	81.6885	NM_006313
USP15	hsa-miR-548am-3p	81.6885	NM_006313
USP15	hsa-miR-548ae-3p	81.6885	NM_006313
USP15	hsa-miR-1290	81.5411	NM_006313
USP15	hsa-miR-1252-3p	80.9606	NM_006313
USP15	hsa-miR-2682-5p	80.8806	NM_001252078
USP15	hsa-miR-34b-5p	80.8806	NM_001252078
USP15	hsa-miR-449c-5p	80.8806	NM_001252078
USP15	hsa-miR-1279	80.6743	NM_006313
USP15	hsa-miR-4261	80.5644	NM_001252078
USP15	hsa-miR-410-3p	80.546	NM_006313
USP15	hsa-miR-10398-5p	80.5115	NM_006313
USP15	hsa-miR-3685	80.3485	NM_006313
USP15	hsa-miR-4491	80.1726	NM_001252079
USP15	hsa-miR-4657	80.1726	NM_001252079

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Motifs and transcription factors (TFs) regulating USP15

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
USP15	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
USP15	metacluster_3.10	KLF2; KLF4 (directAnnotation).
USP15	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
USP15	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
USP15	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
USP15	cisbp__M00341	PAX6 (directAnnotation).
USP15	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
USP15	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
USP15	metacluster_7.13	ZFX (directAnnotation).
USP15	cisbp__M00968	MTF2 (directAnnotation).
USP15	transfac_pro__M04817	ZBTB33 (directAnnotation).
USP15	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
USP15	jaspar__MA0748.2	YY2 (directAnnotation).
USP15	taipale_tf_pairs__ERF_PITX1_NSCGGANNNNNNGGMTTA_CAP	ERF; PITX1 (directAnnotation).
USP15	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
USP15	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
USP15	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
USP15	jaspar__MA1460.1	YY1 (inferredBy_Orthology).
USP15	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
USP15	hdpi__EBF1	EBF1 (directAnnotation).
USP15	metacluster_101.3	MYB (directAnnotation).
USP15	hdpi__TP73	TP73 (directAnnotation).
USP15	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
USP15	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
USP15	taipale_tf_pairs__E2F3_EOMES_NNGYGNNNNGGCGCSNNNNCRCNN_CAP_repr	E2F3; EOMES (directAnnotation).
USP15	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
USP15	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
USP15	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
USP15	transfac_pro__M06259	ZNF91 (directAnnotation).
USP15	metacluster_172.6	CHD2; E2F1 (directAnnotation).
USP15	cisbp__M02645	ETS1 (directAnnotation).
USP15	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
USP15	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
USP15	hdpi__TIMELESS	TIMELESS (directAnnotation).
USP15	transfac_pro__M05893	ZNF676 (directAnnotation).
USP15	hdpi__ETV4	ETV4 (directAnnotation).
USP15	taipale_tf_pairs__E2F1_EOMES_RGGTGTNNNGGCGSNNTNNCRSNN_CAP	E2F1; EOMES (directAnnotation).
USP15	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
USP15	metacluster_135.11	NR2C2 (directAnnotation).
USP15	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
USP15	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
USP15	metacluster_160.20	JUND; PRDM15 (directAnnotation).
USP15	metacluster_198.3	ZFP64 (directAnnotation).
USP15	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
USP15	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
USP15	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
USP15	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
USP15	cisbp__M00788	ZFY (inferredBy_Orthology).
USP15	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
USP15	metacluster_175.1	ZNF283 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."