Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: USP13

Summary for USP13

Gene information	Gene symbol	USP13
	Ensembl ID	ENSG00000058056
	Entrez ID	8975
	Gene name	ubiquitin specific peptidase 13
	Synonyms	IsoT-3
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: USP13

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.251309	0.00e+00

Top

Expression of USP13 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to USP13

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating USP13

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
USP13	hsa-miR-508-5p	83.0936	NM_003940
USP13	hsa-miR-4671-3p	82.9167	NM_003940
USP13	hsa-miR-129-1-3p	82.8252	NM_003940
USP13	hsa-miR-129-2-3p	82.8252	NM_003940
USP13	hsa-miR-4277	82.2267	NM_003940
USP13	hsa-miR-4441	82.163	NM_003940
USP13	hsa-miR-6856-5p	81.7685	NM_003940
USP13	hsa-miR-500b-3p	81.5676	NM_003940
USP13	hsa-miR-208b-5p	81.5512	NM_003940
USP13	hsa-miR-208a-5p	81.5512	NM_003940
USP13	hsa-miR-1305	80.7564	NM_003940
USP13	hsa-miR-4704-3p	80.4857	NM_003940
USP13	hsa-miR-3942-3p	80.4788	NM_003940
USP13	hsa-miR-2053	80.4266	NM_003940
USP13	hsa-miR-4503	80.2815	NM_003940

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating USP13

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
USP13	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
USP13	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
USP13	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
USP13	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
USP13	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
USP13	metacluster_7.13	ZFX (directAnnotation).
USP13	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
USP13	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
USP13	transfac_pro__M01175	ZBTB7B (directAnnotation).
USP13	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
USP13	tfdimers__MD00151	CHURC1 (directAnnotation).
USP13	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
USP13	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
USP13	transfac_pro__M01303	SP1 (directAnnotation).
USP13	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
USP13	transfac_pro__M02090	E2F4 (directAnnotation).
USP13	transfac_pro__M01714	KLF15 (directAnnotation).
USP13	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
USP13	transfac_pro__M02089	E2F3 (directAnnotation).
USP13	metacluster_3.14	WT1; WT1 (directAnnotation).
USP13	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
USP13	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
USP13	cisbp__M07938	E2F1 (directAnnotation).
USP13	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
USP13	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
USP13	transfac_pro__M02898	SMAD3 (directAnnotation).
USP13	transfac_public__M00491	PATZ1 (directAnnotation).
USP13	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."