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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ULK2

Summary for ULK2

Gene information	Gene symbol	ULK2
	Ensembl ID	ENSG00000083290
	Entrez ID	9706
	Gene name	unc-51 like autophagy activating kinase 2
	Synonyms	ATG1B\|KIAA0623\|Unc51.2
	Gene type	protein_coding
	UniProtAcc	Q8IYT8

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Dataset with differentially expressed gene: ULK2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.258609	1.72e-18

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Expression of ULK2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ULK2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ULK2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ULK2	hsa-miR-1910-3p	86.6139	NM_014683
ULK2	hsa-miR-5692a	86.4716	NM_014683
ULK2	hsa-miR-6079	86.4386	NM_014683
ULK2	hsa-miR-548ag	86.0171	NM_014683
ULK2	hsa-miR-548ba	86.0171	NM_014683
ULK2	hsa-miR-548ai	86.0171	NM_014683
ULK2	hsa-miR-570-5p	86.0171	NM_014683
ULK2	hsa-miR-384	85.8178	NM_014683
ULK2	hsa-miR-486-5p	85.2454	NM_014683
ULK2	hsa-miR-12136	84.9943	NM_014683
ULK2	hsa-miR-1271-3p	83.9725	NM_014683
ULK2	hsa-miR-550a-5p	83.9725	NM_014683
ULK2	hsa-miR-550a-3-5p	83.9725	NM_014683
ULK2	hsa-miR-653-3p	83.8755	NM_014683
ULK2	hsa-miR-6852-5p	83.4186	NM_014683
ULK2	hsa-miR-6739-3p	82.8996	NM_014683
ULK2	hsa-miR-7-5p	82.8379	NM_014683
ULK2	hsa-miR-6777-3p	82.6266	NM_014683
ULK2	hsa-miR-3145-5p	81.4926	NM_014683
ULK2	hsa-miR-4422	81.4744	NM_014683
ULK2	hsa-miR-548ax	81.4441	NM_014683
ULK2	hsa-miR-548ao-5p	81.4441	NM_014683
ULK2	hsa-miR-4328	81.3296	NM_014683
ULK2	hsa-miR-519d-5p	81.0696	NM_014683
ULK2	hsa-miR-6785-5p	81.0625	NM_014683
ULK2	hsa-miR-4297	80.8918	NM_001142610
ULK2	hsa-miR-6077	80.6522	NM_014683
ULK2	hsa-miR-4790-3p	80.2302	NM_014683

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Motifs and transcription factors (TFs) regulating ULK2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ULK2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
ULK2	metacluster_7.13	ZFX (directAnnotation).
ULK2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ULK2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ULK2	cisbp__M01863	ZNF711 (inferredBy_Orthology).
ULK2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
ULK2	taipale_cyt_meth__KLF12_NGCCGACGCCCW_FL_meth_repr	KLF12 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ULK2	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."