Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UHMK1

Summary for UHMK1

Gene information	Gene symbol	UHMK1
	Ensembl ID	ENSG00000152332
	Entrez ID	127933
	Gene name	U2AF homology motif kinase 1
	Synonyms	KIS\|Kist
	Gene type	protein_coding
	UniProtAcc	Q8TAS1

Top

Dataset with differentially expressed gene: UHMK1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.324549	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.271396	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.500903	1.63e-29
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.519176	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.03885	0.00e+00

Top

Expression of UHMK1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to UHMK1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating UHMK1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UHMK1	hsa-miR-548h-3p	82.9167	NM_001184763
UHMK1	hsa-miR-4719	82.7745	NM_144624
UHMK1	hsa-miR-206	82.7172	NM_144624
UHMK1	hsa-miR-548aq-3p	82.5422	NM_001184763
UHMK1	hsa-miR-548ah-3p	82.5422	NM_001184763
UHMK1	hsa-miR-548am-3p	82.5422	NM_001184763
UHMK1	hsa-miR-548j-3p	82.5422	NM_001184763
UHMK1	hsa-miR-548ae-3p	82.5422	NM_001184763
UHMK1	hsa-miR-7-1-3p	82.2246	NM_001184763
UHMK1	hsa-miR-1-5p	82.1176	NM_001184763
UHMK1	hsa-miR-6077	81.91	NM_144624
UHMK1	hsa-miR-148b-5p	81.737	NM_001184763
UHMK1	hsa-miR-6874-3p	81.737	NM_001184763
UHMK1	hsa-miR-3619-5p	81.26	NM_001184763
UHMK1	hsa-miR-23c	81.1496	NM_144624
UHMK1	hsa-miR-23b-3p	81.1496	NM_144624
UHMK1	hsa-miR-23a-3p	81.1496	NM_144624
UHMK1	hsa-miR-4310	80.9049	NM_001184763
UHMK1	hsa-miR-374b-3p	80.5756	NM_144624
UHMK1	hsa-miR-302e	80.491	NM_144624
UHMK1	hsa-miR-1-3p	80.4784	NM_144624
UHMK1	hsa-miR-613	80.4784	NM_144624
UHMK1	hsa-miR-4482-3p	80.4271	NM_001184763
UHMK1	hsa-miR-7158-5p	80.3562	NM_001184763
UHMK1	hsa-miR-559	80.2155	NM_001184763
UHMK1	hsa-miR-17-3p	80.1015	NM_144624
UHMK1	hsa-miR-7-2-3p	80.0502	NM_001184763

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating UHMK1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UHMK1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."