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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: UGCG

Summary for UGCG

Gene information	Gene symbol	UGCG
	Ensembl ID	ENSG00000148154
	Entrez ID	7357
	Gene name	UDP-glucose ceramide glucosyltransferase
	Synonyms	GCS
	Gene type	protein_coding
	UniProtAcc	Q16739

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Dataset with differentially expressed gene: UGCG

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.412133	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	pDCs	0.427007	7.08e-03
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.336794	7.10e-13
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	pDCs	1.41741	6.95e-05
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.330659	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.82741	0.00e+00

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Expression of UGCG in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to UGCG

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UGCG

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UGCG	hsa-miR-548h-3p	83.9883	NM_003358
UGCG	hsa-miR-548z	83.9883	NM_003358
UGCG	hsa-miR-548d-3p	83.9883	NM_003358
UGCG	hsa-miR-548ac	83.9883	NM_003358
UGCG	hsa-let-7d-5p	83.8273	NM_003358
UGCG	hsa-miR-1-5p	83.7811	NM_003358
UGCG	hsa-miR-12125	83.3878	NM_003358
UGCG	hsa-miR-137-3p	83.0284	NM_003358
UGCG	hsa-miR-548aw	82.6194	NM_003358
UGCG	hsa-let-7e-5p	82.5879	NM_003358
UGCG	hsa-miR-98-5p	82.5879	NM_003358
UGCG	hsa-let-7f-5p	82.5879	NM_003358
UGCG	hsa-let-7a-5p	82.5879	NM_003358
UGCG	hsa-let-7c-5p	82.5879	NM_003358
UGCG	hsa-let-7b-5p	82.5879	NM_003358
UGCG	hsa-let-7g-5p	82.5879	NM_003358
UGCG	hsa-let-7i-5p	82.5879	NM_003358
UGCG	hsa-miR-4458	82.0766	NM_003358
UGCG	hsa-miR-196a-1-3p	81.758	NM_003358
UGCG	hsa-miR-5587-5p	81.2632	NM_003358
UGCG	hsa-miR-3912-5p	80.6553	NM_003358
UGCG	hsa-miR-130a-5p	80.3246	NM_003358

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Motifs and transcription factors (TFs) regulating UGCG

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UGCG	transfac_pro__M07436	WT1 (directAnnotation).
UGCG	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
UGCG	transfac_pro__M04916	TAF1 (directAnnotation).
UGCG	metacluster_3.14	WT1; WT1 (directAnnotation).
UGCG	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
UGCG	transfac_pro__M02089	E2F3 (directAnnotation).
UGCG	transfac_pro__M07329	SP7 (directAnnotation).
UGCG	transfac_pro__M01122	ZNF219 (directAnnotation).
UGCG	kznf__ZNF311_Imbeault2017_RP_ChIP-seq	ZNF311 (directAnnotation).
UGCG	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
UGCG	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
UGCG	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
UGCG	transfac_pro__M08819	KLF2 (directAnnotation).
UGCG	transfac_pro__M01175	ZBTB7B (directAnnotation).
UGCG	cisbp__M00249	WT1 (directAnnotation).
UGCG	transfac_pro__M01118	WT1 (directAnnotation).
UGCG	swissregulon__hs__KLF6	KLF6 (directAnnotation).
UGCG	transfac_pro__M01303	SP1 (directAnnotation).
UGCG	transfac_pro__M04595	SALL2 (directAnnotation).
UGCG	tfdimers__MD00483	ZBTB14 (directAnnotation).
UGCG	transfac_pro__M01837	KLF11 (directAnnotation).
UGCG	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
UGCG	transfac_pro__M00716	ZBTB14 (directAnnotation).
UGCG	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
UGCG	metacluster_133.2	CPSF4; CPSF4; E2F4; FOXO3; KLF13; KLF15; KLF17; KLF5; MAZ; MAZ; MAZ; MZF1; PATZ1; PATZ1; PATZ1; PATZ1; PLAG1; PRDM9; SP4; VEZF1; WT1; ZBTB17; ZBTB7A; ZBTB7A; ZBTB7B; ZNF148; ZNF148; ZNF148; ZNF148; ZNF180; ZNF180; ZNF202; ZNF219; ZNF219; ZNF263; ZNF263; ZNF28; ZNF281; ZNF281; ZNF281; ZNF281; ZNF281; ZNF383; ZNF398; ZNF398; ZNF444; ZNF444; ZNF467; ZNF543; ZNF543; ZNF641; ZNF692; ZNF737; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF880; ZNF880 (directAnnotation). MAZ; PLAG1; PLAGL1; SP1; SP5; SP5; ZBTB17; ZNF281; ZNF281; ZNF281; ZNF641; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
UGCG	transfac_pro__M07397	ZNF148 (directAnnotation).
UGCG	transfac_pro__M12686	ZBTB10 (directAnnotation).
UGCG	transfac_pro__M00807	EGR1; EGR2; EGR3 (directAnnotation).
UGCG	transfac_pro__M01104	OVOL2 (directAnnotation).
UGCG	transfac_pro__M00986	CHURC1 (directAnnotation).
UGCG	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
UGCG	transfac_pro__M07310	SP5 (directAnnotation).
UGCG	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
UGCG	transfac_pro__M03876	ZBTB33 (directAnnotation).
UGCG	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
UGCG	jaspar__MA0748.2	YY2 (directAnnotation).
UGCG	dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1	GMEB2 (directAnnotation).
UGCG	transfac_pro__M00652	NRF1 (directAnnotation).
UGCG	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
UGCG	hdpi__EBF1	EBF1 (directAnnotation).
UGCG	hdpi__TP73	TP73 (directAnnotation).
UGCG	transfac_pro__M04950	EGR1 (directAnnotation).
UGCG	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
UGCG	metacluster_45.6	E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F4; E2F4 (directAnnotation). E2F2; E2F3 (inferredBy_Orthology).
UGCG	taipale_tf_pairs__E2F3_EOMES_NNGYGNNNNGGCGCSNNNNCRCNN_CAP_repr	E2F3; EOMES (directAnnotation).
UGCG	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
UGCG	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
UGCG	transfac_pro__M06259	ZNF91 (directAnnotation).
UGCG	cisbp__M02645	ETS1 (directAnnotation).
UGCG	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
UGCG	"Eliglustat"	DB09039	small molecule
UGCG	"Miglustat"	DB00419	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."