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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UBE2W

Summary for UBE2W

Gene information	Gene symbol	UBE2W
	Ensembl ID	ENSG00000104343
	Entrez ID	55284
	Gene name	ubiquitin conjugating enzyme E2 W
	Synonyms	FLJ11011\|UBC-16
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: UBE2W

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.278125	2.77e-23
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.469171	0.00e+00

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Expression of UBE2W in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to UBE2W

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UBE2W

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UBE2W	hsa-miR-3156-3p	90.1147	NM_001001481
UBE2W	hsa-miR-548j-3p	89.9373	NM_001001481
UBE2W	hsa-miR-548aq-3p	89.9373	NM_001001481
UBE2W	hsa-miR-548ah-3p	89.9373	NM_001001481
UBE2W	hsa-miR-548am-3p	89.9373	NM_001001481
UBE2W	hsa-miR-548ae-3p	89.9373	NM_001001481
UBE2W	hsa-miR-335-3p	89.9108	NM_018299
UBE2W	hsa-miR-890	89.6992	NM_018299
UBE2W	hsa-miR-128-3p	89.6657	NM_001001481
UBE2W	hsa-miR-216a-3p	89.6657	NM_001001481
UBE2W	hsa-miR-548x-3p	89.5128	NM_001001481
UBE2W	hsa-miR-548aj-3p	89.5128	NM_001001481
UBE2W	hsa-miR-548m	89.1775	NM_018299
UBE2W	hsa-miR-548n	88.8286	NM_001001481
UBE2W	hsa-miR-4511	88.7936	NM_001001481
UBE2W	hsa-miR-300	88.7464	NM_001001481
UBE2W	hsa-miR-381-3p	88.7464	NM_001001481
UBE2W	hsa-miR-3681-3p	88.5735	NM_001001481
UBE2W	hsa-miR-651-5p	88.4422	NM_018299
UBE2W	hsa-miR-1184	88.3756	NM_001001481
UBE2W	hsa-miR-5706	88.1554	NM_018299
UBE2W	hsa-miR-4782-5p	88.1554	NM_018299
UBE2W	hsa-miR-3182	88.1301	NM_001001481
UBE2W	hsa-miR-145-5p	87.6523	NM_001001481
UBE2W	hsa-miR-5195-3p	87.6523	NM_001001481
UBE2W	hsa-miR-3646	87.6485	NM_018299
UBE2W	hsa-miR-6074	87.1171	NM_001001481
UBE2W	hsa-miR-330-5p	86.8153	NM_018299
UBE2W	hsa-miR-6819-5p	85.9161	NM_018299
UBE2W	hsa-miR-6737-5p	85.9161	NM_018299
UBE2W	hsa-miR-541-5p	85.8714	NM_018299
UBE2W	hsa-miR-570-3p	85.8429	NM_001001481
UBE2W	hsa-miR-95-5p	85.7198	NM_001001481
UBE2W	hsa-miR-586	85.5745	NM_001001481
UBE2W	hsa-miR-1827	85.5559	NM_018299
UBE2W	hsa-miR-2278	84.7845	NM_018299
UBE2W	hsa-miR-326	84.7761	NM_018299
UBE2W	hsa-miR-1277-5p	84.5266	NM_001001481
UBE2W	hsa-miR-3613-3p	84.2123	NM_001001481
UBE2W	hsa-miR-6812-5p	84.0271	NM_018299
UBE2W	hsa-miR-302c-5p	83.9648	NM_001001481
UBE2W	hsa-miR-4756-5p	83.7865	NM_018299
UBE2W	hsa-miR-1321	83.7865	NM_018299
UBE2W	hsa-miR-4739	83.6415	NM_018299
UBE2W	hsa-miR-5011-5p	83.5609	NM_018299
UBE2W	hsa-miR-196a-1-3p	83.2778	NM_001001481
UBE2W	hsa-miR-561-3p	83.147	NM_001001481
UBE2W	hsa-miR-224-5p	83.0818	NM_001001481
UBE2W	hsa-miR-4295	82.5141	NM_001001481
UBE2W	hsa-miR-4427	82.5102	NM_018299

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Motifs and transcription factors (TFs) regulating UBE2W

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UBE2W	metacluster_135.11	NR2C2 (directAnnotation).
UBE2W	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
UBE2W	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
UBE2W	metacluster_7.13	ZFX (directAnnotation).
UBE2W	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
UBE2W	cisbp__M00968	MTF2 (directAnnotation).
UBE2W	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
UBE2W	metacluster_160.20	JUND; PRDM15 (directAnnotation).
UBE2W	cisbp__M00341	PAX6 (directAnnotation).
UBE2W	metacluster_198.3	ZFP64 (directAnnotation).
UBE2W	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
UBE2W	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
UBE2W	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
UBE2W	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
UBE2W	cisbp__M00788	ZFY (inferredBy_Orthology).
UBE2W	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
UBE2W	metacluster_175.1	ZNF283 (directAnnotation).
UBE2W	hdpi__ZNF304	ZNF304 (directAnnotation).
UBE2W	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
UBE2W	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
UBE2W	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
UBE2W	transfac_pro__M01199	TRIM28 (directAnnotation).
UBE2W	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
UBE2W	metacluster_151.2	ZNF23 (directAnnotation).
UBE2W	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
UBE2W	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
UBE2W	transfac_pro__M03806	ZBTB7C (directAnnotation).
UBE2W	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
UBE2W	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
UBE2W	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
UBE2W	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
UBE2W	cisbp__M00249	WT1 (directAnnotation).
UBE2W	cisbp__M01863	ZNF711 (inferredBy_Orthology).
UBE2W	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
UBE2W	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
UBE2W	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
UBE2W	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."