Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TWF1

Summary for TWF1

Gene information	Gene symbol	TWF1
	Ensembl ID	ENSG00000151239
	Entrez ID	5756
	Gene name	twinfilin actin binding protein 1
	Synonyms	A6\|PTK9
	Gene type	protein_coding
	UniProtAcc	Q12792

Top

Dataset with differentially expressed gene: TWF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.297896	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.401208	1.14e-43

Top

Expression of TWF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to TWF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
TWF1	Unusual Activation of Pro-survival Pathway

Page: 1

Top

MicroRNAs (miRNA) regulating TWF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TWF1	hsa-miR-3689a-5p	87.5796	NM_002822
TWF1	hsa-miR-3689f	87.5796	NM_002822
TWF1	hsa-miR-3689e	87.5796	NM_002822
TWF1	hsa-miR-302e	87.5597	NM_002822
TWF1	hsa-miR-4465	87.4747	NM_001242397
TWF1	hsa-miR-1299	87.4436	NM_001242397
TWF1	hsa-miR-6890-3p	87.4061	NM_002822
TWF1	hsa-miR-12131	87.0263	NM_002822
TWF1	hsa-miR-561-3p	86.2689	NM_002822
TWF1	hsa-miR-302a-3p	85.3912	NM_002822
TWF1	hsa-miR-520b-3p	85.3912	NM_002822
TWF1	hsa-miR-372-3p	85.3912	NM_002822
TWF1	hsa-miR-302c-3p	85.3912	NM_002822
TWF1	hsa-miR-520c-3p	85.3912	NM_002822
TWF1	hsa-miR-302d-3p	85.3912	NM_002822
TWF1	hsa-miR-302b-3p	85.3912	NM_002822
TWF1	hsa-miR-373-3p	85.3912	NM_002822
TWF1	hsa-miR-520e-3p	85.3912	NM_002822
TWF1	hsa-miR-520d-3p	85.3912	NM_002822
TWF1	hsa-miR-520a-3p	85.3912	NM_002822
TWF1	hsa-miR-3606-3p	84.983	NM_001242397
TWF1	hsa-miR-5582-5p	84.6197	NM_001242397
TWF1	hsa-miR-4311	84.2398	NM_002822
TWF1	hsa-miR-214-3p	84.0405	NM_001242397
TWF1	hsa-miR-4802-3p	83.4089	NM_002822
TWF1	hsa-miR-4302	83.1701	NM_002822
TWF1	hsa-miR-548n	82.9382	NM_001242397
TWF1	hsa-miR-7856-5p	82.1275	NM_001242397
TWF1	hsa-miR-3121-3p	81.8728	NM_002822
TWF1	hsa-miR-3143	81.7177	NM_002822
TWF1	hsa-miR-3658	81.5916	NM_002822
TWF1	hsa-miR-664a-3p	80.4476	NM_002822
TWF1	hsa-miR-32-3p	80.0726	NM_002822

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating TWF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TWF1	metacluster_7.13	ZFX (directAnnotation).
TWF1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
TWF1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
TWF1	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
TWF1	jaspar__MA1483.2	ELF2 (directAnnotation).
TWF1	metacluster_151.2	ZNF23 (directAnnotation).
TWF1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
TWF1	transfac_pro__M05479	ZNF580 (directAnnotation).
TWF1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
TWF1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
TWF1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TWF1	hdpi__ETV4	ETV4 (directAnnotation).
TWF1	transfac_pro__M06071	ZNF814 (directAnnotation).
TWF1	jaspar__MA0748.2	YY2 (directAnnotation).
TWF1	transfac_pro__M05628	ZNF735 (directAnnotation).
TWF1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
TWF1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
TWF1	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
TWF1	jaspar__MA0079.5	SP1 (directAnnotation).
TWF1	metacluster_135.11	NR2C2 (directAnnotation).
TWF1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TWF1	cisbp__M00968	MTF2 (directAnnotation).
TWF1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
TWF1	cisbp__M00341	PAX6 (directAnnotation).
TWF1	metacluster_198.3	ZFP64 (directAnnotation).
TWF1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TWF1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
TWF1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
TWF1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
TWF1	cisbp__M00788	ZFY (inferredBy_Orthology).
TWF1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
TWF1	metacluster_175.1	ZNF283 (directAnnotation).
TWF1	hdpi__ZNF304	ZNF304 (directAnnotation).
TWF1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
TWF1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
TWF1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
TWF1	transfac_pro__M01199	TRIM28 (directAnnotation).
TWF1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TWF1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TWF1	transfac_pro__M03806	ZBTB7C (directAnnotation).
TWF1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."