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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TSC22D2

Summary for TSC22D2

Gene information	Gene symbol	TSC22D2
	Ensembl ID	ENSG00000196428
	Entrez ID	9819
	Gene name	TSC22 domain family member 2
	Synonyms	KIAA0669\|TILZ4a\|TILZ4b\|TILZ4c
	Gene type	protein_coding
	UniProtAcc	O75157

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Dataset with differentially expressed gene: TSC22D2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.342011	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.283798	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.328087	4.50e-03

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Expression of TSC22D2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TSC22D2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TSC22D2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TSC22D2	hsa-miR-130a-5p	87.5083	NM_014779
TSC22D2	hsa-miR-548av-3p	87.4882	NM_001303264
TSC22D2	hsa-miR-1260a	87.1633	NM_014779
TSC22D2	hsa-miR-1260b	87.1633	NM_014779
TSC22D2	hsa-miR-4457	86.9443	NM_014779
TSC22D2	hsa-miR-4704-5p	86.6112	NM_001303264
TSC22D2	hsa-miR-4284	86.5581	NM_001303264
TSC22D2	hsa-miR-4768-5p	86.529	NM_001303264
TSC22D2	hsa-miR-4774-3p	86.3354	NM_001303264
TSC22D2	hsa-miR-4328	86.158	NM_014779
TSC22D2	hsa-miR-205-3p	85.9557	NM_014779
TSC22D2	hsa-miR-548bb-3p	85.8691	NM_001303264
TSC22D2	hsa-miR-548ac	85.8691	NM_001303264
TSC22D2	hsa-miR-548h-3p	85.8691	NM_001303264
TSC22D2	hsa-miR-548d-3p	85.8691	NM_001303264
TSC22D2	hsa-miR-548z	85.8691	NM_001303264
TSC22D2	hsa-miR-4659a-5p	85.1644	NM_001303264
TSC22D2	hsa-miR-486-5p	85.0569	NM_001303264
TSC22D2	hsa-miR-548aj-3p	84.8081	NM_001303264
TSC22D2	hsa-miR-548x-3p	84.8081	NM_001303264
TSC22D2	hsa-miR-200b-3p	84.6517	NM_014779
TSC22D2	hsa-miR-200c-3p	84.6517	NM_014779
TSC22D2	hsa-miR-429	84.6517	NM_014779
TSC22D2	hsa-miR-4731-3p	84.3929	NM_001303264
TSC22D2	hsa-miR-137-3p	84.2528	NM_001303264
TSC22D2	hsa-miR-4500	83.8654	NM_001303264
TSC22D2	hsa-miR-548g-3p	83.5261	NM_014779
TSC22D2	hsa-miR-3133	83.4832	NM_014779
TSC22D2	hsa-miR-15a-5p	83.4689	NM_001303264
TSC22D2	hsa-miR-503-5p	83.4689	NM_001303264
TSC22D2	hsa-miR-15b-5p	83.4689	NM_001303264
TSC22D2	hsa-miR-16-5p	83.4689	NM_001303264
TSC22D2	hsa-miR-195-5p	83.4689	NM_001303264
TSC22D2	hsa-miR-3942-3p	83.2555	NM_014779
TSC22D2	hsa-miR-4698	83.2426	NM_001303264
TSC22D2	hsa-miR-544a	83.1598	NM_014779
TSC22D2	hsa-miR-885-5p	82.992	NM_001303264
TSC22D2	hsa-miR-6876-5p	82.5997	NM_001303264
TSC22D2	hsa-miR-4476	82.5997	NM_001303264
TSC22D2	hsa-miR-1323	82.4762	NM_001303264
TSC22D2	hsa-miR-4724-5p	82.394	NM_014779
TSC22D2	hsa-miR-6076	82.3293	NM_014779
TSC22D2	hsa-miR-548o-3p	82.261	NM_001303264
TSC22D2	hsa-miR-6797-3p	82.233	NM_014779
TSC22D2	hsa-miR-6838-5p	82.1566	NM_001303264
TSC22D2	hsa-miR-497-5p	82.1566	NM_001303264
TSC22D2	hsa-miR-424-5p	82.1566	NM_001303264
TSC22D2	hsa-miR-646	82.1566	NM_001303264
TSC22D2	hsa-miR-1-5p	81.341	NM_014779
TSC22D2	hsa-miR-1284	81.2157	NM_014779

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Motifs and transcription factors (TFs) regulating TSC22D2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TSC22D2	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
TSC22D2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
TSC22D2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
TSC22D2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
TSC22D2	hdpi__ETV4	ETV4 (directAnnotation).
TSC22D2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
TSC22D2	transfac_pro__M04866	HDAC2 (directAnnotation).
TSC22D2	jaspar__MA1122.1	TFDP1 (directAnnotation).
TSC22D2	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
TSC22D2	metacluster_135.11	NR2C2 (directAnnotation).
TSC22D2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
TSC22D2	tfdimers__MD00038	TFAP2C (directAnnotation).
TSC22D2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TSC22D2	metacluster_7.13	ZFX (directAnnotation).
TSC22D2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TSC22D2	cisbp__M00968	MTF2 (directAnnotation).
TSC22D2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
TSC22D2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
TSC22D2	cisbp__M00341	PAX6 (directAnnotation).
TSC22D2	metacluster_198.3	ZFP64 (directAnnotation).
TSC22D2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TSC22D2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
TSC22D2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
TSC22D2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
TSC22D2	cisbp__M00788	ZFY (inferredBy_Orthology).
TSC22D2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
TSC22D2	metacluster_175.1	ZNF283 (directAnnotation).
TSC22D2	hdpi__ZNF304	ZNF304 (directAnnotation).
TSC22D2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
TSC22D2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
TSC22D2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
TSC22D2	transfac_pro__M01199	TRIM28 (directAnnotation).
TSC22D2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
TSC22D2	metacluster_151.2	ZNF23 (directAnnotation).
TSC22D2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TSC22D2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TSC22D2	transfac_pro__M03806	ZBTB7C (directAnnotation).
TSC22D2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TSC22D2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
TSC22D2	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
TSC22D2	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
TSC22D2	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
TSC22D2	jaspar__MA1721.1	ZNF93 (directAnnotation).
TSC22D2	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
TSC22D2	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
TSC22D2	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
TSC22D2	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
TSC22D2	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
TSC22D2	transfac_pro__M01253	CNOT3 (directAnnotation).
TSC22D2	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."