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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TRPS1

Summary for TRPS1

Gene information	Gene symbol	TRPS1
	Ensembl ID	ENSG00000104447
	Entrez ID	7227
	Gene name	transcriptional repressor GATA binding 1
	Synonyms	GC79\|LGCR
	Gene type	protein_coding
	UniProtAcc	Q9UHF7

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Dataset with differentially expressed gene: TRPS1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.624184	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.688465	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.369755	2.66e-43

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Expression of TRPS1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TRPS1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TRPS1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TRPS1	hsa-miR-6782-3p	87.0841	NM_001282902
TRPS1	hsa-miR-548c-3p	86.9106	NM_001282902
TRPS1	hsa-miR-6715b-5p	86.6622	NM_001282902
TRPS1	hsa-miR-4269	86.6622	NM_001282902
TRPS1	hsa-miR-889-3p	86.6582	NM_001282903
TRPS1	hsa-miR-591	86.6049	NM_001282902
TRPS1	hsa-miR-409-5p	86.5763	NM_001282902
TRPS1	hsa-miR-130a-5p	86.1344	NM_001282903
TRPS1	hsa-miR-19b-2-5p	85.9712	NM_001282902
TRPS1	hsa-miR-19b-1-5p	85.9712	NM_001282902
TRPS1	hsa-miR-19a-5p	85.9712	NM_001282902
TRPS1	hsa-miR-4753-3p	85.9037	NM_001282903
TRPS1	hsa-miR-4425	85.6554	NM_001282903
TRPS1	hsa-miR-10226	85.652	NM_001282903
TRPS1	hsa-miR-3928-3p	85.2606	NM_001282902
TRPS1	hsa-miR-4272	85.2331	NM_001282903
TRPS1	hsa-miR-190b-5p	84.859	NM_001282903
TRPS1	hsa-miR-190a-5p	84.859	NM_001282903
TRPS1	hsa-miR-92a-1-5p	84.5229	NM_001282903
TRPS1	hsa-miR-4773	84.0611	NM_001282902
TRPS1	hsa-miR-374a-5p	84.0504	NM_001282903
TRPS1	hsa-miR-4712-3p	84.048	NM_001282903
TRPS1	hsa-miR-504-3p	84.0459	NM_001282902
TRPS1	hsa-miR-5582-3p	84.037	NM_001282903
TRPS1	hsa-miR-6505-5p	84.0273	NM_001282903
TRPS1	hsa-miR-451b	83.8346	NM_001282902
TRPS1	hsa-miR-590-3p	83.7528	NM_001282903
TRPS1	hsa-miR-155-5p	83.7306	NM_001282903
TRPS1	hsa-miR-4708-5p	83.7248	NM_001282902
TRPS1	hsa-miR-4480	83.4603	NM_001282902
TRPS1	hsa-miR-4456	83.3564	NM_001282902
TRPS1	hsa-miR-218-5p	83.2798	NM_001282902
TRPS1	hsa-miR-4703-5p	83.2139	NM_001282903
TRPS1	hsa-miR-3942-5p	83.2139	NM_001282903
TRPS1	hsa-miR-12123	83.1723	NM_001282903
TRPS1	hsa-miR-1250-3p	83.1253	NM_001282903
TRPS1	hsa-miR-5692a	83.0452	NM_001282903
TRPS1	hsa-miR-302e	82.8175	NM_001282903
TRPS1	hsa-miR-3913-5p	82.6263	NM_001282903
TRPS1	hsa-miR-122b-5p	82.6075	NM_001282902
TRPS1	hsa-miR-374a-3p	82.3669	NM_001282903
TRPS1	hsa-miR-3156-5p	81.4975	NM_001282902
TRPS1	hsa-miR-206	81.3116	NM_001282902
TRPS1	hsa-miR-183-3p	81.2933	NM_001282903
TRPS1	hsa-miR-587	81.0883	NM_001282903
TRPS1	hsa-miR-4328	81.0865	NM_001282903
TRPS1	hsa-miR-552-5p	80.9437	NM_001282903
TRPS1	hsa-miR-374b-5p	80.7372	NM_001282903
TRPS1	hsa-miR-138-2-3p	80.6811	NM_001282903
TRPS1	hsa-miR-6071	80.6714	NM_001282903

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Motifs and transcription factors (TFs) regulating TRPS1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TRPS1	transfac_pro__M07436	WT1 (directAnnotation).
TRPS1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
TRPS1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TRPS1	transfac_pro__M02089	E2F3 (directAnnotation).
TRPS1	transfac_pro__M01122	ZNF219 (directAnnotation).
TRPS1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
TRPS1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
TRPS1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
TRPS1	transfac_pro__M08819	KLF2 (directAnnotation).
TRPS1	transfac_public__M00415	ZEB1 (directAnnotation).
TRPS1	transfac_pro__M01175	ZBTB7B (directAnnotation).
TRPS1	cisbp__M00249	WT1 (directAnnotation).
TRPS1	transfac_pro__M01118	WT1 (directAnnotation).
TRPS1	swissregulon__hs__KLF6	KLF6 (directAnnotation).
TRPS1	transfac_pro__M01303	SP1 (directAnnotation).
TRPS1	transfac_pro__M04595	SALL2 (directAnnotation).
TRPS1	transfac_pro__M01837	KLF11 (directAnnotation).
TRPS1	transfac_pro__M00716	ZBTB14 (directAnnotation).
TRPS1	metacluster_133.2	CPSF4; CPSF4; E2F4; FOXO3; KLF13; KLF15; KLF17; KLF5; MAZ; MAZ; MAZ; MZF1; PATZ1; PATZ1; PATZ1; PATZ1; PLAG1; PRDM9; SP4; VEZF1; WT1; ZBTB17; ZBTB7A; ZBTB7A; ZBTB7B; ZNF148; ZNF148; ZNF148; ZNF148; ZNF180; ZNF180; ZNF202; ZNF219; ZNF219; ZNF263; ZNF263; ZNF28; ZNF281; ZNF281; ZNF281; ZNF281; ZNF281; ZNF383; ZNF398; ZNF398; ZNF444; ZNF444; ZNF467; ZNF543; ZNF543; ZNF641; ZNF692; ZNF737; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF880; ZNF880 (directAnnotation). MAZ; PLAG1; PLAGL1; SP1; SP5; SP5; ZBTB17; ZNF281; ZNF281; ZNF281; ZNF641; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
TRPS1	tfdimers__MD00376	HOXA13; KLF4 (directAnnotation).
TRPS1	transfac_pro__M07397	ZNF148 (directAnnotation).
TRPS1	transfac_pro__M12686	ZBTB10 (directAnnotation).
TRPS1	transfac_pro__M00807	EGR1; EGR2; EGR3 (directAnnotation).
TRPS1	transfac_pro__M01104	OVOL2 (directAnnotation).
TRPS1	taipale_tf_pairs__TEAD4_ELK1_RMATWCCGGAWRN_CAP_repr	ELK1; TEAD4 (directAnnotation).
TRPS1	transfac_pro__M06520	ZNF721 (directAnnotation).
TRPS1	transfac_pro__M00986	CHURC1 (directAnnotation).
TRPS1	transfac_pro__M04918	EGR1 (directAnnotation).
TRPS1	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
TRPS1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TRPS1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
TRPS1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
TRPS1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
TRPS1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
TRPS1	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
TRPS1	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
TRPS1	transfac_pro__M01861	ATF1 (directAnnotation).
TRPS1	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
TRPS1	transfac_pro__M00801	ATF1; ATF2; ATF3; ATF4; ATF7; CREB1; CREM (directAnnotation). ATF7-NPFF (inferredBy_Orthology).
TRPS1	hocomoco__GMEB2_HUMAN.H11MO.0.D	GMEB2 (directAnnotation).
TRPS1	transfac_public__M00039	CREB1 (directAnnotation).
TRPS1	transfac_public__M00040	ATF2 (directAnnotation).
TRPS1	taipale_cyt_meth__JUND_NRTGACGCATN_eDBD_repr	JUND (directAnnotation).
TRPS1	transfac_pro__M01864	ATF4 (directAnnotation).
TRPS1	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
TRPS1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
TRPS1	metacluster_180.3	ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6B; ATF7; ATF7; BACH2; BATF3; BATF3; CREB1; CREB1; CREB3; FOSL1; FOSL2; JDP2; JUN; JUN; JUN; JUND; JUND; XBP1; ZBTB21 (directAnnotation). JDP2; JDP2; JUND (inferredBy_Orthology).
TRPS1	hdpi__NRL	NRL (directAnnotation).
TRPS1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
TRPS1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."