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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TRIO

Summary for TRIO

Gene information	Gene symbol	TRIO
	Ensembl ID	ENSG00000038382
	Entrez ID	7204
	Gene name	trio Rho guanine nucleotide exchange factor
	Synonyms	ARHGEF23
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TRIO

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.52456	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.535555	0.00e+00

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Expression of TRIO in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TRIO

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TRIO

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TRIO	hsa-miR-4660	88.3868	NM_007118
TRIO	hsa-miR-3123	88.2963	NM_007118
TRIO	hsa-miR-4736	87.3549	NM_007118
TRIO	hsa-miR-450a-1-3p	87.3481	NM_007118
TRIO	hsa-miR-21-3p	86.6893	NM_007118
TRIO	hsa-miR-122b-3p	86.6893	NM_007118
TRIO	hsa-miR-6809-3p	86.5807	NM_007118
TRIO	hsa-miR-7150	86.1673	NM_007118
TRIO	hsa-miR-377-3p	86.0543	NM_007118
TRIO	hsa-miR-4470	86.0042	NM_007118
TRIO	hsa-miR-381-3p	85.921	NM_007118
TRIO	hsa-miR-300	85.921	NM_007118
TRIO	hsa-miR-32-5p	85.6982	NM_007118
TRIO	hsa-miR-363-3p	85.6982	NM_007118
TRIO	hsa-miR-92b-3p	85.6982	NM_007118
TRIO	hsa-miR-92a-3p	85.6982	NM_007118
TRIO	hsa-miR-367-3p	85.6982	NM_007118
TRIO	hsa-miR-8068	85.5861	NM_007118
TRIO	hsa-miR-4499	85.5615	NM_007118
TRIO	hsa-miR-452-3p	84.7903	NM_007118
TRIO	hsa-miR-4495	84.729	NM_007118
TRIO	hsa-miR-3665	83.6329	NM_007118
TRIO	hsa-miR-144-3p	83.258	NM_007118
TRIO	hsa-miR-25-3p	82.0392	NM_007118
TRIO	hsa-miR-4753-3p	82.0263	NM_007118
TRIO	hsa-miR-30d-5p	81.838	NM_007118
TRIO	hsa-miR-30b-5p	81.838	NM_007118
TRIO	hsa-miR-30c-5p	81.838	NM_007118
TRIO	hsa-miR-30e-5p	81.838	NM_007118
TRIO	hsa-miR-30a-5p	81.838	NM_007118
TRIO	hsa-miR-96-5p	81.4169	NM_007118
TRIO	hsa-miR-182-5p	81.4169	NM_007118
TRIO	hsa-miR-4789-3p	80.2851	NM_007118
TRIO	hsa-miR-4643	80.2851	NM_007118

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Motifs and transcription factors (TFs) regulating TRIO

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TRIO	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
TRIO	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
TRIO	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
TRIO	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
TRIO	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
TRIO	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
TRIO	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
TRIO	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
TRIO	transfac_pro__M04866	HDAC2 (directAnnotation).
TRIO	jaspar__MA1122.1	TFDP1 (directAnnotation).
TRIO	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
TRIO	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
TRIO	metacluster_7.13	ZFX (directAnnotation).
TRIO	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TRIO	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
TRIO	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TRIO	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TRIO	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
TRIO	cisbp__M01863	ZNF711 (inferredBy_Orthology).
TRIO	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
TRIO	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
TRIO	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."