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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TRIM33

Summary for TRIM33

Gene information	Gene symbol	TRIM33
	Ensembl ID	ENSG00000197323
	Entrez ID	51592
	Gene name	tripartite motif containing 33
	Synonyms	FLJ11429\|KIAA1113\|PTC7\|RFG7\|TF1G\|TIF1G\|TIF1GAMMA\|TIFGAMMA
	Gene type	protein_coding
	UniProtAcc	Q9UPN9

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Dataset with differentially expressed gene: TRIM33

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.313645	2.29e-23
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.251212	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.253516	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.326864	0.00e+00

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Expression of TRIM33 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TRIM33

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TRIM33

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TRIM33	hsa-miR-548aw	91.9264	NM_015906
TRIM33	hsa-miR-4776-3p	91.9099	NM_015906
TRIM33	hsa-miR-4463	91.7939	NM_015906
TRIM33	hsa-miR-7162-3p	91.4338	NM_015906
TRIM33	hsa-miR-466	91.3837	NM_015906
TRIM33	hsa-miR-3682-5p	91.1108	NM_015906
TRIM33	hsa-miR-3123	90.9496	NM_015906
TRIM33	hsa-miR-6839-3p	90.7629	NM_015906
TRIM33	hsa-miR-545-3p	90.747	NM_015906
TRIM33	hsa-miR-6830-5p	90.4395	NM_015906
TRIM33	hsa-miR-513c-3p	90.3346	NM_015906
TRIM33	hsa-miR-513a-3p	90.3346	NM_015906
TRIM33	hsa-miR-4318	90.2591	NM_015906
TRIM33	hsa-miR-7856-5p	90.0893	NM_015906
TRIM33	hsa-miR-409-3p	89.0894	NM_015906
TRIM33	hsa-miR-4663	89.0468	NM_015906
TRIM33	hsa-miR-548n	89.0153	NM_015906
TRIM33	hsa-miR-3129-3p	88.9323	NM_015906
TRIM33	hsa-miR-5583-5p	88.9323	NM_015906
TRIM33	hsa-miR-7151-3p	88.6983	NM_015906
TRIM33	hsa-miR-6504-3p	88.4054	NM_015906
TRIM33	hsa-miR-3606-3p	88.0301	NM_015906
TRIM33	hsa-miR-3163	87.7499	NM_015906
TRIM33	hsa-miR-3924	87.4535	NM_015906
TRIM33	hsa-miR-4519	87.4214	NM_015906
TRIM33	hsa-miR-137-3p	87.4043	NM_015906
TRIM33	hsa-miR-4303	87.0595	NM_015906
TRIM33	hsa-miR-548az-5p	86.5356	NM_015906
TRIM33	hsa-miR-548t-5p	86.5356	NM_015906
TRIM33	hsa-miR-455-5p	86.5324	NM_015906
TRIM33	hsa-miR-370-3p	86.1385	NM_015906
TRIM33	hsa-miR-6893-3p	86.1385	NM_015906
TRIM33	hsa-miR-20b-3p	86.0884	NM_015906
TRIM33	hsa-miR-4786-5p	86.0012	NM_015906
TRIM33	hsa-miR-4773	85.6734	NM_015906
TRIM33	hsa-miR-10399-5p	85.3938	NM_015906
TRIM33	hsa-miR-1277-5p	85.3933	NM_015906
TRIM33	hsa-miR-525-5p	85.2305	NM_015906
TRIM33	hsa-miR-520a-5p	85.2305	NM_015906
TRIM33	hsa-miR-888-5p	85.1176	NM_015906
TRIM33	hsa-miR-3914	85.0272	NM_015906
TRIM33	hsa-miR-2117	84.6621	NM_015906
TRIM33	hsa-miR-5680	84.6522	NM_015906
TRIM33	hsa-miR-633	84.3134	NM_015906
TRIM33	hsa-miR-1299	84.0297	NM_015906
TRIM33	hsa-miR-5579-3p	83.9691	NM_015906
TRIM33	hsa-miR-640	83.6747	NM_015906
TRIM33	hsa-miR-4517	83.2103	NM_015906
TRIM33	hsa-miR-940	83.2022	NM_015906
TRIM33	hsa-miR-6893-5p	83.2022	NM_015906

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Motifs and transcription factors (TFs) regulating TRIM33

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TRIM33	metacluster_151.2	ZNF23 (directAnnotation).
TRIM33	transfac_pro__M05479	ZNF580 (directAnnotation).
TRIM33	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TRIM33	hdpi__ETV4	ETV4 (directAnnotation).
TRIM33	transfac_pro__M06071	ZNF814 (directAnnotation).
TRIM33	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
TRIM33	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
TRIM33	transfac_pro__M04826	EP300 (directAnnotation).
TRIM33	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
TRIM33	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
TRIM33	transfac_pro__M04950	EGR1 (directAnnotation).
TRIM33	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
TRIM33	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
TRIM33	transfac_pro__M00652	NRF1 (directAnnotation).
TRIM33	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
TRIM33	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
TRIM33	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
TRIM33	transfac_pro__M04918	EGR1 (directAnnotation).
TRIM33	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
TRIM33	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
TRIM33	transfac_pro__M01122	ZNF219 (directAnnotation).
TRIM33	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
TRIM33	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
TRIM33	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
TRIM33	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
TRIM33	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
TRIM33	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
TRIM33	jaspar__MA1721.1	ZNF93 (directAnnotation).
TRIM33	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
TRIM33	transfac_pro__M01199	TRIM28 (directAnnotation).
TRIM33	tfdimers__MD00391	KLF4 (directAnnotation).
TRIM33	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
TRIM33	cisbp__M00968	MTF2 (directAnnotation).
TRIM33	transfac_pro__M12697	ZNF142 (directAnnotation).
TRIM33	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
TRIM33	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
TRIM33	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
TRIM33	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."