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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TRAF3

Summary for TRAF3

Gene information	Gene symbol	TRAF3
	Ensembl ID	ENSG00000131323
	Entrez ID	7187
	Gene name	TNF receptor associated factor 3
	Synonyms	CAP-1\|CD40bp\|CRAF1\|LAP1\|RNF118
	Gene type	protein_coding
	UniProtAcc	Q13114

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Dataset with differentially expressed gene: TRAF3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.317724	0.00e+00

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Expression of TRAF3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TRAF3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TRAF3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TRAF3	hsa-miR-320a-5p	85.8414	NM_001199427
TRAF3	hsa-miR-124-3p	85.8328	NM_001199427
TRAF3	hsa-miR-506-3p	85.8328	NM_001199427
TRAF3	hsa-miR-8086	85.8074	NM_001199427
TRAF3	hsa-miR-124-5p	85.5475	NM_001199427
TRAF3	hsa-miR-510-3p	85.4915	NM_001199427
TRAF3	hsa-miR-301b-5p	85.4782	NM_001199427
TRAF3	hsa-miR-301a-5p	85.4782	NM_001199427
TRAF3	hsa-miR-4306	85.179	NM_001199427
TRAF3	hsa-miR-4325	84.9537	NM_001199427
TRAF3	hsa-miR-6719-3p	84.8789	NM_001199427
TRAF3	hsa-miR-628-5p	84.4687	NM_001199427
TRAF3	hsa-miR-9718	84.4687	NM_001199427
TRAF3	hsa-miR-3927-5p	84.3251	NM_001199427
TRAF3	hsa-miR-6730-3p	84.1447	NM_001199427
TRAF3	hsa-miR-6825-5p	83.8187	NM_001199427
TRAF3	hsa-miR-1303	83.6562	NM_001199427
TRAF3	hsa-miR-6721-5p	83.4941	NM_001199427
TRAF3	hsa-miR-3620-5p	83.4595	NM_001199427
TRAF3	hsa-miR-653-3p	83.4319	NM_001199427
TRAF3	hsa-miR-3178	82.6472	NM_001199427
TRAF3	hsa-miR-34b-3p	82.4205	NM_001199427
TRAF3	hsa-miR-4267	82.3056	NM_001199427
TRAF3	hsa-miR-1587	82.281	NM_001199427
TRAF3	hsa-miR-10394-3p	82.2383	NM_001199427
TRAF3	hsa-miR-137-3p	82.0694	NM_001199427
TRAF3	hsa-miR-761	81.8885	NM_001199427
TRAF3	hsa-miR-3179	81.4847	NM_001199427
TRAF3	hsa-miR-27a-3p	81.2523	NM_001199427
TRAF3	hsa-miR-9985	81.2523	NM_001199427
TRAF3	hsa-miR-27b-3p	81.2523	NM_001199427
TRAF3	hsa-miR-1227-5p	80.952	NM_001199427
TRAF3	hsa-miR-4659a-3p	80.9236	NM_001199427
TRAF3	hsa-miR-4659b-3p	80.9236	NM_001199427
TRAF3	hsa-miR-944	80.8761	NM_001199427
TRAF3	hsa-miR-3619-5p	80.7242	NM_001199427
TRAF3	hsa-miR-1915-3p	80.5614	NM_001199427
TRAF3	hsa-miR-214-3p	80.2027	NM_001199427

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Motifs and transcription factors (TFs) regulating TRAF3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TRAF3	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
TRAF3	transfac_pro__M04950	EGR1 (directAnnotation).
TRAF3	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
TRAF3	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
TRAF3	transfac_pro__M00652	NRF1 (directAnnotation).
TRAF3	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
TRAF3	transfac_pro__M04866	HDAC2 (directAnnotation).
TRAF3	jaspar__MA1122.1	TFDP1 (directAnnotation).
TRAF3	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."