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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TOB1

Summary for TOB1

Gene information	Gene symbol	TOB1
	Ensembl ID	ENSG00000141232
	Entrez ID	10140
	Gene name	transducer of ERBB2, 1
	Synonyms	APRO5\|TOB\|TROB\|TROB1
	Gene type	protein_coding
	UniProtAcc	P50616

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Dataset with differentially expressed gene: TOB1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.476799	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.331218	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	0.487094	3.60e-18
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	0.405624	9.93e-12
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.915179	6.09e-34
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.579255	1.61e-29
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.32896	2.80e-45
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.435757	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	NK cells	0.448168	8.33e-09
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD4+ T cells	0.327027	3.01e-05
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.257764	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.24839	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.314637	0.00e+00

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Expression of TOB1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TOB1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TOB1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TOB1	hsa-miR-4666a-3p	89.6766	NM_001243885
TOB1	hsa-miR-20b-3p	89.5653	NM_001243885
TOB1	hsa-miR-186-5p	89.1638	NM_001243885
TOB1	hsa-miR-192-3p	88.808	NM_001243877
TOB1	hsa-miR-1297	88.7025	NM_001243885
TOB1	hsa-miR-548c-3p	88.555	NM_001243877
TOB1	hsa-miR-15a-3p	88.5436	NM_001243877
TOB1	hsa-miR-4801	87.9751	NM_001243877
TOB1	hsa-miR-345-5p	87.229	NM_001243885
TOB1	hsa-miR-4731-3p	86.9872	NM_001243877
TOB1	hsa-miR-4671-3p	86.9373	NM_001243877
TOB1	hsa-miR-302b-5p	86.547	NM_001243885
TOB1	hsa-miR-302d-5p	86.547	NM_001243885
TOB1	hsa-miR-511-5p	86.0849	NM_001243885
TOB1	hsa-miR-636	85.6864	NM_001243885
TOB1	hsa-miR-26a-5p	85.3337	NM_001243885
TOB1	hsa-miR-26b-5p	85.3337	NM_001243885
TOB1	hsa-miR-374c-5p	84.7964	NM_001243885
TOB1	hsa-miR-655-3p	84.7964	NM_001243885
TOB1	hsa-miR-4473	83.8109	NM_001243877
TOB1	hsa-miR-4465	83.4823	NM_001243885
TOB1	hsa-miR-4789-5p	83.2055	NM_001243885
TOB1	hsa-miR-889-3p	83.0816	NM_001243885
TOB1	hsa-miR-153-5p	82.6992	NM_001243885
TOB1	hsa-miR-302a-5p	81.9301	NM_001243877
TOB1	hsa-miR-190a-3p	81.6561	NM_001243885
TOB1	hsa-miR-3173-3p	81.2994	NM_001243877
TOB1	hsa-miR-6891-5p	81.2994	NM_001243877
TOB1	hsa-miR-3145-3p	80.9297	NM_001243885

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Motifs and transcription factors (TFs) regulating TOB1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TOB1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
TOB1	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
TOB1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
TOB1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
TOB1	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
TOB1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
TOB1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
TOB1	metacluster_3.14	WT1; WT1 (directAnnotation).
TOB1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
TOB1	cisbp__M07938	E2F1 (directAnnotation).
TOB1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
TOB1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TOB1	transfac_pro__M07397	ZNF148 (directAnnotation).
TOB1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
TOB1	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
TOB1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
TOB1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
TOB1	metacluster_7.13	ZFX (directAnnotation).
TOB1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
TOB1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
TOB1	transfac_pro__M01175	ZBTB7B (directAnnotation).
TOB1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
TOB1	tfdimers__MD00151	CHURC1 (directAnnotation).
TOB1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
TOB1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
TOB1	transfac_pro__M01303	SP1 (directAnnotation).
TOB1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TOB1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
TOB1	transfac_pro__M02090	E2F4 (directAnnotation).
TOB1	transfac_pro__M01714	KLF15 (directAnnotation).
TOB1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
TOB1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
TOB1	transfac_pro__M02089	E2F3 (directAnnotation).
TOB1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
TOB1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
TOB1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
TOB1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
TOB1	transfac_pro__M07436	WT1 (directAnnotation).
TOB1	transfac_pro__M02281	SP1 (directAnnotation).
TOB1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
TOB1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TOB1	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
TOB1	transfac_pro__M02898	SMAD3 (directAnnotation).
TOB1	transfac_public__M00491	PATZ1 (directAnnotation).
TOB1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
TOB1	jaspar__MA0039.4	KLF4 (directAnnotation).
TOB1	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
TOB1	tfdimers__MD00457	SREBF1; SREBF2; ZNF354C (directAnnotation).
TOB1	transfac_pro__M04595	SALL2 (directAnnotation).
TOB1	transfac_pro__M04916	TAF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."