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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TMTC1

Summary for TMTC1

Gene information	Gene symbol	TMTC1
	Ensembl ID	ENSG00000133687
	Entrez ID	83857
	Gene name	transmembrane O-mannosyltransferase targeting cadherins 1
	Synonyms	ARG99\|FLJ31400\|FLJ41625\|OLF
	Gene type	protein_coding
	UniProtAcc	Q8IUR5

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Dataset with differentially expressed gene: TMTC1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.256104	5.43e-11
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.327419	3.87e-13
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.30598	4.50e-09

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Expression of TMTC1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TMTC1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TMTC1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TMTC1	hsa-miR-6835-3p	91.1886	NM_001193451
TMTC1	hsa-miR-9-5p	90.561	NM_001193451
TMTC1	hsa-miR-5696	90.1237	NM_001193451
TMTC1	hsa-miR-4314	89.9838	NM_001193451
TMTC1	hsa-miR-4728-5p	89.8007	NM_001193451
TMTC1	hsa-miR-6785-5p	89.8007	NM_001193451
TMTC1	hsa-miR-410-3p	89.505	NM_001193451
TMTC1	hsa-miR-548f-5p	89.1361	NM_001193451
TMTC1	hsa-miR-548g-5p	89.1361	NM_001193451
TMTC1	hsa-miR-548x-5p	89.1361	NM_001193451
TMTC1	hsa-miR-548aj-5p	89.1361	NM_001193451
TMTC1	hsa-miR-616-5p	88.989	NM_001193451
TMTC1	hsa-miR-371b-5p	88.989	NM_001193451
TMTC1	hsa-miR-373-5p	88.989	NM_001193451
TMTC1	hsa-miR-1250-3p	88.6217	NM_001193451
TMTC1	hsa-miR-4266	88.5045	NM_001193451
TMTC1	hsa-miR-4297	88.0814	NM_001193451
TMTC1	hsa-miR-340-5p	87.8621	NM_001193451
TMTC1	hsa-miR-149-3p	87.545	NM_001193451
TMTC1	hsa-miR-6883-5p	87.545	NM_001193451
TMTC1	hsa-miR-2355-5p	87.107	NM_001193451
TMTC1	hsa-miR-4433b-5p	86.3057	NM_001193451
TMTC1	hsa-miR-24-3p	85.4739	NM_001193451
TMTC1	hsa-miR-5571-5p	85.4663	NM_001193451
TMTC1	hsa-miR-6780a-5p	85.2198	NM_001193451
TMTC1	hsa-miR-656-3p	84.8725	NM_001193451
TMTC1	hsa-miR-3692-3p	84.5012	NM_001193451
TMTC1	hsa-miR-8075	84.2604	NM_001193451
TMTC1	hsa-miR-3151-3p	84.0182	NM_001193451
TMTC1	hsa-let-7a-2-3p	83.6042	NM_001193451
TMTC1	hsa-let-7g-3p	83.6042	NM_001193451
TMTC1	hsa-miR-330-3p	83.5471	NM_001193451
TMTC1	hsa-miR-6878-5p	83.3849	NM_001193451
TMTC1	hsa-miR-802	83.2376	NM_001193451
TMTC1	hsa-miR-4255	82.8529	NM_001193451
TMTC1	hsa-miR-6126	82.8505	NM_001193451
TMTC1	hsa-miR-1468-3p	82.6523	NM_001193451
TMTC1	hsa-miR-3192-5p	82.6219	NM_001193451
TMTC1	hsa-miR-27b-5p	82.3479	NM_001193451
TMTC1	hsa-miR-30b-3p	82.2153	NM_001193451
TMTC1	hsa-miR-3689a-3p	82.2153	NM_001193451
TMTC1	hsa-miR-3689c	82.2153	NM_001193451
TMTC1	hsa-miR-1273h-5p	82.2153	NM_001193451
TMTC1	hsa-miR-6779-5p	82.2153	NM_001193451
TMTC1	hsa-miR-3689b-3p	82.2153	NM_001193451
TMTC1	hsa-miR-3133	82.1423	NM_001193451
TMTC1	hsa-miR-4795-3p	81.8488	NM_001193451
TMTC1	hsa-miR-200a-3p	81.8311	NM_001193451
TMTC1	hsa-miR-141-3p	81.8311	NM_001193451
TMTC1	hsa-miR-7106-5p	81.7649	NM_001193451

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Motifs and transcription factors (TFs) regulating TMTC1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TMTC1	jaspar__MA0079.5	SP1 (directAnnotation).
TMTC1	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
TMTC1	taipale_cyt_meth__ZNF460_NAACGCCCCCCGN_eDBD_repr	ZNF460 (directAnnotation).
TMTC1	transfac_pro__M01253	CNOT3 (directAnnotation).
TMTC1	hdpi__NFIX	NFIX (directAnnotation).
TMTC1	transfac_pro__M04817	ZBTB33 (directAnnotation).
TMTC1	cisbp__M07938	E2F1 (directAnnotation).
TMTC1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
TMTC1	metacluster_2.7	IRF1; IRF1; IRF2; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF7; IRF8; IRF8; IRF9; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; STAT1; STAT1; STAT2 (directAnnotation). PRDM1; PRDM1; PRDM1 (inferredBy_Orthology).
TMTC1	taipale_tf_pairs__TEAD4_PITX1_RCATWCNNNNNGGATTA_CAP_repr	PITX1; TEAD4 (directAnnotation).
TMTC1	metacluster_14.23	TFE3 (directAnnotation).
TMTC1	transfac_pro__M07260	IKZF1 (directAnnotation).
TMTC1	transfac_pro__M01835	KLF4 (directAnnotation).
TMTC1	hocomoco__PATZ1_HUMAN.H11MO.1.C	PATZ1 (directAnnotation).
TMTC1	swissregulon__hs__MTA3	MTA3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."