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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TMF1

Summary for TMF1

Gene information	Gene symbol	TMF1
	Ensembl ID	ENSG00000144747
	Entrez ID	7110
	Gene name	TATA element modulatory factor 1
	Synonyms	ARA160\|TMF
	Gene type	protein_coding
	UniProtAcc	P82094

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Dataset with differentially expressed gene: TMF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.325803	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.35391	2.80e-45
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.437604	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.277166	1.40e-45
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.285285	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.354172	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.359179	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.476923	0.00e+00

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Expression of TMF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TMF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TMF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TMF1	hsa-miR-1185-2-3p	85.163	NM_007114
TMF1	hsa-miR-1185-1-3p	85.163	NM_007114
TMF1	hsa-miR-708-3p	85.0309	NM_007114
TMF1	hsa-miR-548at-5p	84.9556	NM_007114
TMF1	hsa-miR-543	83.9152	NM_007114
TMF1	hsa-miR-20b-3p	83.5049	NM_007114
TMF1	hsa-miR-524-5p	82.9107	NM_007114
TMF1	hsa-miR-520d-5p	82.9107	NM_007114
TMF1	hsa-miR-6849-5p	82.2212	NM_007114
TMF1	hsa-miR-651-3p	81.9052	NM_007114
TMF1	hsa-miR-6889-3p	80.8616	NM_007114
TMF1	hsa-miR-3163	80.8357	NM_007114
TMF1	hsa-miR-3606-3p	80.7545	NM_007114
TMF1	hsa-miR-181d-5p	80.4901	NM_007114
TMF1	hsa-miR-181a-5p	80.4901	NM_007114
TMF1	hsa-miR-181b-5p	80.4901	NM_007114
TMF1	hsa-miR-181c-5p	80.4901	NM_007114
TMF1	hsa-miR-4263	80.1094	NM_007114
TMF1	hsa-miR-4778-5p	80.0684	NM_007114
TMF1	hsa-miR-561-5p	80.0384	NM_007114

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Motifs and transcription factors (TFs) regulating TMF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TMF1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
TMF1	jaspar__MA1483.2	ELF2 (directAnnotation).
TMF1	hdpi__ETV4	ETV4 (directAnnotation).
TMF1	jaspar__MA1933.1	SREBF2 (directAnnotation).
TMF1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
TMF1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
TMF1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
TMF1	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
TMF1	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
TMF1	hdpi__TIMELESS	TIMELESS (directAnnotation).
TMF1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
TMF1	metacluster_191.5	SPDEF (inferredBy_Orthology).
TMF1	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
TMF1	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
TMF1	hdpi__ELF2	ELF2 (directAnnotation).
TMF1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
TMF1	jaspar__MA1122.1	TFDP1 (directAnnotation).
TMF1	metacluster_19.6	GMEB1 (directAnnotation). GMEB1 (inferredBy_Orthology).
TMF1	jaspar__MA1721.1	ZNF93 (directAnnotation).
TMF1	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
TMF1	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
TMF1	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
TMF1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
TMF1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
TMF1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."