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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TMEM65

Summary for TMEM65

Gene information	Gene symbol	TMEM65
	Ensembl ID	ENSG00000164983
	Entrez ID	157378
	Gene name	transmembrane protein 65
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q6PI78

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Dataset with differentially expressed gene: TMEM65

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.27838	1.01e-06
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.281352	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.31541	1.39e-23

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Expression of TMEM65 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TMEM65

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TMEM65

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TMEM65	hsa-miR-519c-5p	92.0623	NM_194291
TMEM65	hsa-miR-519a-5p	92.0623	NM_194291
TMEM65	hsa-let-7b-5p	91.7561	NM_194291
TMEM65	hsa-miR-98-5p	91.7561	NM_194291
TMEM65	hsa-let-7a-5p	91.7561	NM_194291
TMEM65	hsa-let-7c-5p	91.7561	NM_194291
TMEM65	hsa-let-7e-5p	91.7561	NM_194291
TMEM65	hsa-let-7f-5p	91.7561	NM_194291
TMEM65	hsa-miR-219b-5p	91.373	NM_194291
TMEM65	hsa-miR-4458	91.027	NM_194291
TMEM65	hsa-let-7d-5p	91.027	NM_194291
TMEM65	hsa-miR-202-3p	91.027	NM_194291
TMEM65	hsa-miR-12123	88.8454	NM_194291
TMEM65	hsa-miR-29a-3p	87.6055	NM_194291
TMEM65	hsa-miR-29c-3p	87.6055	NM_194291
TMEM65	hsa-miR-29b-3p	87.6055	NM_194291
TMEM65	hsa-miR-7159-5p	87.5878	NM_194291
TMEM65	hsa-miR-5009-3p	87.5335	NM_194291
TMEM65	hsa-miR-12136	87.5165	NM_194291
TMEM65	hsa-miR-302c-5p	87.323	NM_194291
TMEM65	hsa-miR-548e-5p	87.1843	NM_194291
TMEM65	hsa-miR-4279	87.0078	NM_194291
TMEM65	hsa-miR-944	86.0659	NM_194291
TMEM65	hsa-miR-126-5p	85.8863	NM_194291
TMEM65	hsa-miR-4439	85.7426	NM_194291
TMEM65	hsa-miR-3136-5p	85.7426	NM_194291
TMEM65	hsa-miR-605-5p	85.536	NM_194291
TMEM65	hsa-miR-186-5p	85.2732	NM_194291
TMEM65	hsa-miR-6826-3p	85.0158	NM_194291
TMEM65	hsa-miR-590-3p	84.8991	NM_194291
TMEM65	hsa-miR-122b-5p	84.811	NM_194291
TMEM65	hsa-miR-4643	84.8033	NM_194291
TMEM65	hsa-miR-2277-3p	84.383	NM_194291
TMEM65	hsa-miR-3163	83.4589	NM_194291
TMEM65	hsa-miR-6814-5p	83.3907	NM_194291
TMEM65	hsa-miR-576-3p	83.1955	NM_194291
TMEM65	hsa-miR-217-5p	82.6927	NM_194291
TMEM65	hsa-miR-9983-3p	82.4596	NM_194291
TMEM65	hsa-miR-4668-5p	81.8217	NM_194291
TMEM65	hsa-miR-3148	81.2306	NM_194291
TMEM65	hsa-miR-4426	80.4645	NM_194291
TMEM65	hsa-miR-6807-3p	80.1336	NM_194291

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Motifs and transcription factors (TFs) regulating TMEM65

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TMEM65	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
TMEM65	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
TMEM65	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
TMEM65	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
TMEM65	transfac_pro__M04617	ZBTB7A (directAnnotation).
TMEM65	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
TMEM65	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
TMEM65	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
TMEM65	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
TMEM65	transfac_pro__M07387	ZBTB7A (directAnnotation).
TMEM65	transfac_pro__M07436	WT1 (directAnnotation).
TMEM65	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
TMEM65	transfac_pro__M00716	ZBTB14 (directAnnotation).
TMEM65	swissregulon__hs__CHD1	CHD1 (directAnnotation).
TMEM65	hdpi__HIP2	UBE2K (directAnnotation).
TMEM65	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
TMEM65	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
TMEM65	transfac_pro__M04893	TAF1 (directAnnotation).
TMEM65	transfac_pro__M03876	ZBTB33 (directAnnotation).
TMEM65	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
TMEM65	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
TMEM65	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
TMEM65	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TMEM65	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
TMEM65	metacluster_135.11	NR2C2 (directAnnotation).
TMEM65	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
TMEM65	tfdimers__MD00038	TFAP2C (directAnnotation).
TMEM65	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TMEM65	metacluster_7.13	ZFX (directAnnotation).
TMEM65	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TMEM65	cisbp__M00968	MTF2 (directAnnotation).
TMEM65	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
TMEM65	metacluster_160.20	JUND; PRDM15 (directAnnotation).
TMEM65	cisbp__M00341	PAX6 (directAnnotation).
TMEM65	metacluster_198.3	ZFP64 (directAnnotation).
TMEM65	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TMEM65	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
TMEM65	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
TMEM65	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
TMEM65	cisbp__M00788	ZFY (inferredBy_Orthology).
TMEM65	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
TMEM65	metacluster_175.1	ZNF283 (directAnnotation).
TMEM65	hdpi__ZNF304	ZNF304 (directAnnotation).
TMEM65	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
TMEM65	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
TMEM65	transfac_pro__M01199	TRIM28 (directAnnotation).
TMEM65	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
TMEM65	metacluster_151.2	ZNF23 (directAnnotation).
TMEM65	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TMEM65	transfac_pro__M03806	ZBTB7C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."