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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TMEM33

Summary for TMEM33

Gene information	Gene symbol	TMEM33
	Ensembl ID	ENSG00000109133
	Entrez ID	55161
	Gene name	transmembrane protein 33
	Synonyms	FLJ10525\|Pom33
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TMEM33

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.254038	3.98e-41
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.305783	9.99e-09
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.376475	0.00e+00

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Expression of TMEM33 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TMEM33

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TMEM33

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TMEM33	hsa-miR-551b-5p	92.6793	NM_018126
TMEM33	hsa-miR-4699-3p	92.3865	NM_018126
TMEM33	hsa-miR-100-3p	92.0857	NM_018126
TMEM33	hsa-miR-4698	91.8393	NM_018126
TMEM33	hsa-miR-4503	91.4932	NM_018126
TMEM33	hsa-miR-4760-5p	91.2201	NM_018126
TMEM33	hsa-miR-7-1-3p	91.01	NM_018126
TMEM33	hsa-miR-7-2-3p	91.01	NM_018126
TMEM33	hsa-miR-8061	90.9608	NM_018126
TMEM33	hsa-miR-2115-3p	90.0063	NM_018126
TMEM33	hsa-miR-524-5p	89.6995	NM_018126
TMEM33	hsa-miR-520d-5p	89.6995	NM_018126
TMEM33	hsa-miR-548an	89.6737	NM_018126
TMEM33	hsa-miR-5688	89.5256	NM_018126
TMEM33	hsa-miR-433-3p	89.4383	NM_018126
TMEM33	hsa-miR-5003-3p	89.0573	NM_018126
TMEM33	hsa-miR-203a-3p	89.0402	NM_018126
TMEM33	hsa-miR-126-5p	89.0176	NM_018126
TMEM33	hsa-miR-10b-3p	88.9566	NM_018126
TMEM33	hsa-miR-3613-3p	88.8846	NM_018126
TMEM33	hsa-miR-761	88.5175	NM_018126
TMEM33	hsa-miR-214-3p	88.5175	NM_018126
TMEM33	hsa-miR-3619-5p	88.3233	NM_018126
TMEM33	hsa-miR-3671	88.1754	NM_018126
TMEM33	hsa-miR-495-3p	88.0144	NM_018126
TMEM33	hsa-miR-3163	87.8842	NM_018126
TMEM33	hsa-miR-513c-5p	87.6915	NM_018126
TMEM33	hsa-miR-514b-5p	87.6915	NM_018126
TMEM33	hsa-miR-6806-5p	87.5383	NM_018126
TMEM33	hsa-miR-1301-5p	87.279	NM_018126
TMEM33	hsa-miR-6502-5p	87.279	NM_018126
TMEM33	hsa-miR-651-3p	87.0144	NM_018126
TMEM33	hsa-miR-4686	86.5356	NM_018126
TMEM33	hsa-miR-610	86.3922	NM_018126
TMEM33	hsa-miR-6826-3p	85.1814	NM_018126
TMEM33	hsa-miR-4803	84.8869	NM_018126
TMEM33	hsa-miR-545-5p	84.4755	NM_018126
TMEM33	hsa-miR-6792-5p	84.2754	NM_018126
TMEM33	hsa-miR-4428	84.0804	NM_018126
TMEM33	hsa-miR-1250-3p	83.703	NM_018126
TMEM33	hsa-miR-196a-1-3p	83.6643	NM_018126
TMEM33	hsa-miR-3662	83.4308	NM_018126
TMEM33	hsa-miR-23c	83.2925	NM_018126
TMEM33	hsa-miR-6848-3p	82.8345	NM_018126
TMEM33	hsa-miR-6843-3p	82.8345	NM_018126
TMEM33	hsa-miR-3658	82.5955	NM_018126
TMEM33	hsa-miR-3679-5p	82.5846	NM_018126
TMEM33	hsa-miR-4666a-5p	81.7976	NM_018126
TMEM33	hsa-miR-384	81.717	NM_018126
TMEM33	hsa-miR-8075	81.6439	NM_018126

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Motifs and transcription factors (TFs) regulating TMEM33

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TMEM33	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
TMEM33	jaspar__MA1483.2	ELF2 (directAnnotation).
TMEM33	hdpi__ETV4	ETV4 (directAnnotation).
TMEM33	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
TMEM33	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
TMEM33	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
TMEM33	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
TMEM33	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
TMEM33	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
TMEM33	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
TMEM33	transfac_pro__M04826	EP300 (directAnnotation).
TMEM33	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
TMEM33	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
TMEM33	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
TMEM33	swissregulon__hs__ELF2	ELF2 (directAnnotation).
TMEM33	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
TMEM33	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
TMEM33	cisbp__M02645	ETS1 (directAnnotation).
TMEM33	hdpi__FLI1	FLI1 (directAnnotation).
TMEM33	swissregulon__hs__ETV6	ETV6 (directAnnotation).
TMEM33	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
TMEM33	cisbp__M08198	ELF1 (directAnnotation).
TMEM33	jaspar__MA1708.1	ETV7 (directAnnotation).
TMEM33	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
TMEM33	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
TMEM33	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
TMEM33	hdpi__TP73	TP73 (directAnnotation).
TMEM33	hdpi__ELF2	ELF2 (directAnnotation).
TMEM33	swissregulon__hs__ELK1	ELK1 (directAnnotation).
TMEM33	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
TMEM33	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
TMEM33	metacluster_183.4	ETS1 (inferredBy_Orthology).
TMEM33	metacluster_35.5	ELF1; ELF2; ELF3; ELF3; ELK1; ELK4; ERF; ERG; ETS1; ETS1; ETS2; ETV7; ETV7; FLI1; FLI1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."