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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TM9SF3

Summary for TM9SF3

Gene information	Gene symbol	TM9SF3
	Ensembl ID	ENSG00000077147
	Entrez ID	56889
	Gene name	transmembrane 9 superfamily member 3
	Synonyms	SMBP
	Gene type	protein_coding
	UniProtAcc	Q9HD45

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Dataset with differentially expressed gene: TM9SF3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.484929	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.365165	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.376708	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.382927	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.582335	0.00e+00

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Expression of TM9SF3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TM9SF3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TM9SF3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TM9SF3	hsa-miR-548av-5p	86.9781	NM_020123
TM9SF3	hsa-miR-548k	86.9781	NM_020123
TM9SF3	hsa-miR-8054	86.9781	NM_020123
TM9SF3	hsa-miR-3942-3p	86.9149	NM_020123
TM9SF3	hsa-miR-545-5p	86.6077	NM_020123
TM9SF3	hsa-miR-4778-3p	86.5014	NM_020123
TM9SF3	hsa-miR-145-3p	85.7939	NM_020123
TM9SF3	hsa-miR-6852-3p	85.0358	NM_020123
TM9SF3	hsa-miR-516b-5p	85.0302	NM_020123
TM9SF3	hsa-miR-548ap-3p	84.783	NM_020123
TM9SF3	hsa-miR-548aa	84.783	NM_020123
TM9SF3	hsa-miR-548t-3p	84.783	NM_020123
TM9SF3	hsa-miR-181b-2-3p	84.5938	NM_020123
TM9SF3	hsa-miR-181b-3p	84.5938	NM_020123
TM9SF3	hsa-miR-4420	84.5938	NM_020123
TM9SF3	hsa-miR-3160-5p	84.2254	NM_020123
TM9SF3	hsa-miR-6516-3p	83.6054	NM_020123
TM9SF3	hsa-miR-607	83.5469	NM_020123
TM9SF3	hsa-miR-3130-5p	83.5047	NM_020123
TM9SF3	hsa-miR-651-5p	83.2131	NM_020123
TM9SF3	hsa-miR-3613-3p	83.1027	NM_020123
TM9SF3	hsa-miR-6873-3p	83.0701	NM_020123
TM9SF3	hsa-miR-24-1-5p	82.5113	NM_020123
TM9SF3	hsa-miR-24-2-5p	82.5113	NM_020123
TM9SF3	hsa-miR-141-5p	81.9842	NM_020123
TM9SF3	hsa-miR-4661-3p	81.7203	NM_020123
TM9SF3	hsa-miR-105-5p	81.6371	NM_020123
TM9SF3	hsa-miR-7853-5p	81.6371	NM_020123
TM9SF3	hsa-miR-4782-5p	80.9483	NM_020123
TM9SF3	hsa-miR-5706	80.9483	NM_020123
TM9SF3	hsa-miR-4496	80.8932	NM_020123
TM9SF3	hsa-miR-4422	80.8024	NM_020123
TM9SF3	hsa-miR-8068	80.8013	NM_020123
TM9SF3	hsa-miR-4716-5p	80.5888	NM_020123
TM9SF3	hsa-miR-4709-3p	80.301	NM_020123
TM9SF3	hsa-miR-6834-3p	80.2973	NM_020123
TM9SF3	hsa-miR-12124	80.2611	NM_020123
TM9SF3	hsa-miR-6715b-3p	80.1749	NM_020123

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Motifs and transcription factors (TFs) regulating TM9SF3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TM9SF3	metacluster_7.13	ZFX (directAnnotation).
TM9SF3	cisbp__M01863	ZNF711 (inferredBy_Orthology).
TM9SF3	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
TM9SF3	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
TM9SF3	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
TM9SF3	jaspar__MA1483.2	ELF2 (directAnnotation).
TM9SF3	metacluster_151.2	ZNF23 (directAnnotation).
TM9SF3	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
TM9SF3	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
TM9SF3	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TM9SF3	metacluster_182.10	ZFX (directAnnotation).
TM9SF3	hdpi__ETV4	ETV4 (directAnnotation).
TM9SF3	transfac_pro__M06071	ZNF814 (directAnnotation).
TM9SF3	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
TM9SF3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
TM9SF3	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
TM9SF3	jaspar__MA0079.5	SP1 (directAnnotation).
TM9SF3	transfac_pro__M01299	MECP2 (directAnnotation).
TM9SF3	transfac_pro__M06035	ZNF749 (directAnnotation).
TM9SF3	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
TM9SF3	jaspar__MA1596.1	ZNF460 (directAnnotation).
TM9SF3	metacluster_52.11	ZNF184 (directAnnotation).
TM9SF3	metacluster_7.8	ZBTB7A; ZNF28 (directAnnotation).
TM9SF3	metacluster_98.1	ZNF524 (directAnnotation).
TM9SF3	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
TM9SF3	metacluster_135.11	NR2C2 (directAnnotation).
TM9SF3	tfdimers__MD00038	TFAP2C (directAnnotation).
TM9SF3	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TM9SF3	cisbp__M00968	MTF2 (directAnnotation).
TM9SF3	metacluster_160.20	JUND; PRDM15 (directAnnotation).
TM9SF3	cisbp__M00341	PAX6 (directAnnotation).
TM9SF3	metacluster_198.3	ZFP64 (directAnnotation).
TM9SF3	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TM9SF3	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
TM9SF3	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
TM9SF3	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
TM9SF3	cisbp__M00788	ZFY (inferredBy_Orthology).
TM9SF3	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
TM9SF3	metacluster_175.1	ZNF283 (directAnnotation).
TM9SF3	hdpi__ZNF304	ZNF304 (directAnnotation).
TM9SF3	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
TM9SF3	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
TM9SF3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
TM9SF3	transfac_pro__M01199	TRIM28 (directAnnotation).
TM9SF3	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
TM9SF3	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TM9SF3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TM9SF3	transfac_pro__M03806	ZBTB7C (directAnnotation).
TM9SF3	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TM9SF3	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."