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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TET1

Summary for TET1

Gene information	Gene symbol	TET1
	Ensembl ID	ENSG00000138336
	Entrez ID	80312
	Gene name	tet methylcytosine dioxygenase 1
	Synonyms	bA119F7.1\|CXXC6\|KIAA1676\|LCX
	Gene type	protein_coding
	UniProtAcc	Q8NFU7

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Dataset with differentially expressed gene: TET1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.32949	0.00e+00

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Expression of TET1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TET1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TET1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TET1	hsa-miR-7153-3p	90.0819	NM_030625
TET1	hsa-miR-593-5p	89.7622	NM_030625
TET1	hsa-miR-2681-5p	89.6062	NM_030625
TET1	hsa-miR-302e	89.0274	NM_030625
TET1	hsa-miR-6835-3p	88.9676	NM_030625
TET1	hsa-miR-12122	88.7728	NM_030625
TET1	hsa-miR-520c-3p	88.6679	NM_030625
TET1	hsa-miR-520d-3p	88.6679	NM_030625
TET1	hsa-miR-302b-3p	88.6679	NM_030625
TET1	hsa-miR-302d-3p	88.6679	NM_030625
TET1	hsa-miR-302a-3p	88.6679	NM_030625
TET1	hsa-miR-372-3p	88.6679	NM_030625
TET1	hsa-miR-302c-3p	88.6679	NM_030625
TET1	hsa-miR-520a-3p	88.6679	NM_030625
TET1	hsa-miR-520b-3p	88.6679	NM_030625
TET1	hsa-miR-373-3p	88.6679	NM_030625
TET1	hsa-miR-520e-3p	88.6679	NM_030625
TET1	hsa-miR-498-5p	88.3277	NM_030625
TET1	hsa-miR-6809-3p	88.3031	NM_030625
TET1	hsa-miR-12119	87.7505	NM_030625
TET1	hsa-miR-506-3p	87.4207	NM_030625
TET1	hsa-miR-124-3p	87.4207	NM_030625
TET1	hsa-miR-3680-3p	87.3865	NM_030625
TET1	hsa-miR-526b-3p	87.2173	NM_030625
TET1	hsa-miR-6885-3p	87.101	NM_030625
TET1	hsa-miR-4299	86.6999	NM_030625
TET1	hsa-miR-548c-3p	85.6874	NM_030625
TET1	hsa-miR-607	85.6586	NM_030625
TET1	hsa-miR-539-5p	85.5834	NM_030625
TET1	hsa-miR-548an	85.4286	NM_030625
TET1	hsa-miR-9985	85.2293	NM_030625
TET1	hsa-miR-27b-3p	85.2293	NM_030625
TET1	hsa-miR-27a-3p	85.2293	NM_030625
TET1	hsa-miR-3671	84.9765	NM_030625
TET1	hsa-miR-509-3-5p	83.7188	NM_030625
TET1	hsa-miR-509-5p	83.7188	NM_030625
TET1	hsa-miR-95-5p	83.7091	NM_030625
TET1	hsa-miR-6511b-5p	83.6151	NM_030625
TET1	hsa-miR-6811-5p	83.6151	NM_030625
TET1	hsa-miR-196a-1-3p	83.4629	NM_030625
TET1	hsa-miR-580-5p	83.0304	NM_030625
TET1	hsa-miR-188-3p	82.5206	NM_030625
TET1	hsa-miR-3923	82.4824	NM_030625
TET1	hsa-miR-4719	82.361	NM_030625
TET1	hsa-miR-3658	82.3437	NM_030625
TET1	hsa-miR-499b-5p	82.1541	NM_030625
TET1	hsa-miR-361-5p	81.743	NM_030625
TET1	hsa-miR-675-3p	81.563	NM_030625
TET1	hsa-miR-208a-5p	81.2561	NM_030625
TET1	hsa-miR-208b-5p	81.2561	NM_030625

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Motifs and transcription factors (TFs) regulating TET1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TET1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
TET1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TET1	transfac_pro__M07397	ZNF148 (directAnnotation).
TET1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
TET1	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
TET1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
TET1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
TET1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
TET1	metacluster_7.13	ZFX (directAnnotation).
TET1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
TET1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
TET1	transfac_pro__M01175	ZBTB7B (directAnnotation).
TET1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
TET1	tfdimers__MD00151	CHURC1 (directAnnotation).
TET1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
TET1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
TET1	transfac_pro__M01303	SP1 (directAnnotation).
TET1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TET1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
TET1	transfac_pro__M02090	E2F4 (directAnnotation).
TET1	transfac_pro__M01714	KLF15 (directAnnotation).
TET1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
TET1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
TET1	transfac_pro__M02089	E2F3 (directAnnotation).
TET1	metacluster_3.14	WT1; WT1 (directAnnotation).
TET1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
TET1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
TET1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
TET1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
TET1	cisbp__M07938	E2F1 (directAnnotation).
TET1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
TET1	transfac_pro__M07436	WT1 (directAnnotation).
TET1	transfac_pro__M02281	SP1 (directAnnotation).
TET1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
TET1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TET1	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
TET1	transfac_pro__M02898	SMAD3 (directAnnotation).
TET1	transfac_public__M00491	PATZ1 (directAnnotation).
TET1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
TET1	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."