Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TENT4B

Summary for TENT4B

Gene information	Gene symbol	TENT4B
	Ensembl ID	ENSG00000121274
	Entrez ID	64282
	Gene name	terminal nucleotidyltransferase 4B
	Synonyms	PAPD5\|TRF4-2\|TUT3
	Gene type	protein_coding
	UniProtAcc	Q8NDF8

Top

Dataset with differentially expressed gene: TENT4B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.612322	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.499647	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.29668	7.60e-33

Top

Expression of TENT4B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to TENT4B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating TENT4B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TENT4B	hsa-miR-7-2-3p	91.9605	NM_001040284
TENT4B	hsa-miR-7-1-3p	91.9605	NM_001040284
TENT4B	hsa-miR-3941	91.815	NM_001040284
TENT4B	hsa-miR-1468-3p	91.7837	NM_001040284
TENT4B	hsa-miR-34b-3p	90.5069	NM_001040284
TENT4B	hsa-miR-3662	90.5027	NM_001040284
TENT4B	hsa-miR-888-5p	90.3302	NM_001040284
TENT4B	hsa-miR-5195-3p	90.3157	NM_001040284
TENT4B	hsa-miR-145-5p	90.3157	NM_001040284
TENT4B	hsa-miR-4693-5p	90.16	NM_001040284
TENT4B	hsa-miR-340-5p	89.7794	NM_001040284
TENT4B	hsa-miR-6074	89.703	NM_001040284
TENT4B	hsa-miR-5583-5p	89.2963	NM_001040284
TENT4B	hsa-miR-3129-3p	89.2963	NM_001040284
TENT4B	hsa-miR-489-3p	89.2797	NM_001040284
TENT4B	hsa-miR-4715-3p	89.2368	NM_001040284
TENT4B	hsa-miR-4282	89.0142	NM_001040284
TENT4B	hsa-miR-544b	88.9459	NM_001040284
TENT4B	hsa-miR-320d	88.5809	NM_001040284
TENT4B	hsa-miR-4429	88.5809	NM_001040284
TENT4B	hsa-miR-320b	88.5809	NM_001040284
TENT4B	hsa-miR-320c	88.5809	NM_001040284
TENT4B	hsa-miR-320a-3p	88.5809	NM_001040284
TENT4B	hsa-miR-4789-5p	88.5116	NM_001040284
TENT4B	hsa-miR-607	88.4327	NM_001040284
TENT4B	hsa-miR-4775	87.9237	NM_001040284
TENT4B	hsa-miR-379-3p	87.8618	NM_001040284
TENT4B	hsa-miR-411-3p	87.8618	NM_001040284
TENT4B	hsa-miR-7161-5p	87.7665	NM_001040284
TENT4B	hsa-miR-6888-5p	87.6739	NM_001040284
TENT4B	hsa-miR-6883-3p	87.4535	NM_001040284
TENT4B	hsa-miR-373-5p	87.4223	NM_001040284
TENT4B	hsa-miR-616-5p	87.4223	NM_001040284
TENT4B	hsa-miR-371b-5p	87.4223	NM_001040284
TENT4B	hsa-miR-642b-5p	87.3163	NM_001040284
TENT4B	hsa-miR-383-5p	87.0587	NM_001040284
TENT4B	hsa-miR-499a-3p	86.8232	NM_001040284
TENT4B	hsa-miR-499b-3p	86.8232	NM_001040284
TENT4B	hsa-miR-1277-5p	86.7136	NM_001040284
TENT4B	hsa-miR-548ar-3p	86.5452	NM_001040284
TENT4B	hsa-miR-708-3p	86.5087	NM_001040284
TENT4B	hsa-miR-3065-5p	86.4191	NM_001040284
TENT4B	hsa-miR-548u	85.9563	NM_001040284
TENT4B	hsa-miR-640	85.8913	NM_001040284
TENT4B	hsa-miR-6804-5p	85.6698	NM_001040284
TENT4B	hsa-miR-8076	85.4936	NM_001040284
TENT4B	hsa-miR-186-5p	85.4788	NM_001040284
TENT4B	hsa-miR-16-1-3p	85.4594	NM_001040284
TENT4B	hsa-miR-532-3p	85.4551	NM_001040284
TENT4B	hsa-miR-520d-5p	85.3702	NM_001040284

Page: 1 2 3

Top

Motifs and transcription factors (TFs) regulating TENT4B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."