Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: TCF7L2

Summary for TCF7L2

Gene information	Gene symbol	TCF7L2
	Ensembl ID	ENSG00000148737
	Entrez ID	6934
	Gene name	transcription factor 7 like 2
	Synonyms	TCF-4\|TCF4
	Gene type	protein_coding
	UniProtAcc	Q9NQB0

Top

Dataset with differentially expressed gene: TCF7L2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.446971	1.38e-40
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.370695	3.35e-17
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	0.30885	1.48e-31
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.357124	0.00e+00

Top

Expression of TCF7L2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to TCF7L2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating TCF7L2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TCF7L2	hsa-miR-4496	90.3537	NM_001146285
TCF7L2	hsa-miR-12123	90.2277	NM_001146285
TCF7L2	hsa-miR-3140-3p	90.0608	NM_001198525
TCF7L2	hsa-miR-96-5p	89.7341	NM_001198525
TCF7L2	hsa-miR-622	89.6898	NM_001198525
TCF7L2	hsa-miR-548am-3p	89.6852	NM_001146285
TCF7L2	hsa-miR-548ah-3p	89.6852	NM_001146285
TCF7L2	hsa-miR-543	89.6364	NM_001198525
TCF7L2	hsa-miR-1271-5p	89.3212	NM_001198525
TCF7L2	hsa-miR-12133	89.3212	NM_001198525
TCF7L2	hsa-miR-548x-3p	89.0632	NM_001146285
TCF7L2	hsa-miR-548aj-3p	89.0632	NM_001146285
TCF7L2	hsa-miR-509-3p	88.8794	NM_001198525
TCF7L2	hsa-miR-890	88.0402	NM_001146285
TCF7L2	hsa-miR-3120-3p	87.9268	NM_001146285
TCF7L2	hsa-miR-548ae-3p	87.2583	NM_001146285
TCF7L2	hsa-miR-548j-3p	87.2583	NM_001146285
TCF7L2	hsa-miR-548aq-3p	87.2583	NM_001146285
TCF7L2	hsa-miR-183-5p	87.1976	NM_001146285
TCF7L2	hsa-miR-6515-3p	87.1443	NM_001198525
TCF7L2	hsa-miR-4428	86.7539	NM_001146285
TCF7L2	hsa-miR-6882-3p	86.5074	NM_001198525
TCF7L2	hsa-miR-328-5p	86.038	NM_001146285
TCF7L2	hsa-miR-6885-5p	86.038	NM_001146285
TCF7L2	hsa-miR-4495	85.7155	NM_001146285
TCF7L2	hsa-miR-497-3p	85.6667	NM_001198525
TCF7L2	hsa-miR-495-5p	85.2972	NM_001146285
TCF7L2	hsa-miR-6505-5p	85.0992	NM_001146285
TCF7L2	hsa-miR-1237-3p	84.933	NM_001146285
TCF7L2	hsa-miR-155-5p	84.4624	NM_001146285
TCF7L2	hsa-miR-5582-3p	83.3012	NM_001198525
TCF7L2	hsa-miR-545-3p	82.8901	NM_001146285
TCF7L2	hsa-miR-802	82.8807	NM_001146285
TCF7L2	hsa-miR-10526-3p	82.5678	NM_001198525
TCF7L2	hsa-miR-6820-5p	81.9854	NM_001198525
TCF7L2	hsa-miR-3973	81.8232	NM_001146285
TCF7L2	hsa-miR-3151-3p	81.4197	NM_001198525
TCF7L2	hsa-miR-181b-3p	81.1703	NM_001198525
TCF7L2	hsa-miR-181b-2-3p	81.1703	NM_001198525
TCF7L2	hsa-miR-4420	81.1703	NM_001198525
TCF7L2	hsa-miR-26a-1-3p	81.09	NM_001198525
TCF7L2	hsa-miR-26a-2-3p	81.09	NM_001198525
TCF7L2	hsa-miR-5696	80.5402	NM_001146285
TCF7L2	hsa-miR-5589-3p	80.2565	NM_001198525
TCF7L2	hsa-miR-187-5p	80.2115	NM_001146285
TCF7L2	hsa-miR-3686	80.1502	NM_001146285

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating TCF7L2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TCF7L2	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
TCF7L2	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
TCF7L2	metacluster_7.13	ZFX (directAnnotation).
TCF7L2	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
TCF7L2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TCF7L2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TCF7L2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
TCF7L2	cisbp__M00249	WT1 (directAnnotation).
TCF7L2	cisbp__M01863	ZNF711 (inferredBy_Orthology).
TCF7L2	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
TCF7L2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
TCF7L2	transfac_pro__M05432	ZSCAN18 (directAnnotation).
TCF7L2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TCF7L2	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
TCF7L2	metacluster_151.2	ZNF23 (directAnnotation).
TCF7L2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
TCF7L2	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
TCF7L2	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
TCF7L2	transfac_pro__M01199	TRIM28 (directAnnotation).
TCF7L2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
TCF7L2	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
TCF7L2	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
TCF7L2	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
TCF7L2	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
TCF7L2	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
TCF7L2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
TCF7L2	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
TCF7L2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
TCF7L2	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
TCF7L2	transfac_pro__M00938	E2F1 (directAnnotation).
TCF7L2	transfac_pro__M04893	TAF1 (directAnnotation).
TCF7L2	transfac_pro__M04817	ZBTB33 (directAnnotation).
TCF7L2	transfac_pro__M12697	ZNF142 (directAnnotation).
TCF7L2	metacluster_175.1	ZNF283 (directAnnotation).
TCF7L2	cisbp__M00788	ZFY (inferredBy_Orthology).
TCF7L2	tfdimers__MD00364	WT1 (directAnnotation).
TCF7L2	hdpi__ZNF304	ZNF304 (directAnnotation).
TCF7L2	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
TCF7L2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
TCF7L2	transfac_pro__M04916	TAF1 (directAnnotation).
TCF7L2	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
TCF7L2	transfac_pro__M01973	PLAG1 (directAnnotation).
TCF7L2	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
TCF7L2	tfdimers__MD00483	ZBTB14 (directAnnotation).
TCF7L2	metacluster_198.3	ZFP64 (directAnnotation).
TCF7L2	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
TCF7L2	transfac_pro__M01303	SP1 (directAnnotation).
TCF7L2	metacluster_143.13	ZBTB7A (directAnnotation).
TCF7L2	tfdimers__MD00552	USF2; ZBTB14 (directAnnotation).
TCF7L2	transfac_pro__M07387	ZBTB7A (directAnnotation).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
TCF7L2	tfdimers__MD00145	up	Mono/Macro	GSE189460	pre
TCF7L2	tfdimers__MD00145	down	Mono/Macro	GSE207422_Sin	post

Page: 1

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."