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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TCF12

Summary for TCF12

Gene information	Gene symbol	TCF12
	Ensembl ID	ENSG00000140262
	Entrez ID	6938
	Gene name	transcription factor 12
	Synonyms	bHLHb20\|HEB\|HsT17266\|HTF4\|p64
	Gene type	protein_coding
	UniProtAcc	Q99081

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Dataset with differentially expressed gene: TCF12

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.351425	4.98e-32

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Expression of TCF12 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TCF12

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TCF12

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TCF12	hsa-miR-337-3p	91.7863	NM_003205
TCF12	hsa-miR-6832-3p	91.7406	NM_003205
TCF12	hsa-miR-3613-3p	91.2916	NM_003205
TCF12	hsa-miR-4482-3p	90.9768	NM_001322158
TCF12	hsa-miR-6529-5p	90.9267	NM_003205
TCF12	hsa-miR-4711-3p	90.2477	NM_003205
TCF12	hsa-miR-4693-5p	90.2205	NM_001322154
TCF12	hsa-miR-4516	89.813	NM_001322158
TCF12	hsa-miR-1303	89.7145	NM_003205
TCF12	hsa-miR-6508-5p	89.183	NM_001322158
TCF12	hsa-miR-183-5p	89.1558	NM_003205
TCF12	hsa-miR-3922-5p	89.042	NM_003205
TCF12	hsa-miR-3942-3p	88.9512	NM_003205
TCF12	hsa-miR-4656	88.6436	NM_003205
TCF12	hsa-miR-3159	88.2477	NM_001322158
TCF12	hsa-miR-4502	88.2118	NM_001322158
TCF12	hsa-miR-4447	88.1854	NM_001322159
TCF12	hsa-miR-551b-5p	88.0487	NM_001322158
TCF12	hsa-miR-8067	87.6672	NM_001322158
TCF12	hsa-miR-582-5p	87.5195	NM_001322154
TCF12	hsa-miR-4644	87.3576	NM_003205
TCF12	hsa-miR-4306	87.3576	NM_003205
TCF12	hsa-miR-592	86.5853	NM_003205
TCF12	hsa-miR-149-5p	86.2762	NM_003205
TCF12	hsa-miR-542-3p	86.2552	NM_001322158
TCF12	hsa-miR-599	86.1881	NM_003205
TCF12	hsa-miR-7-5p	86.0621	NM_003205
TCF12	hsa-miR-95-5p	85.7971	NM_001322158
TCF12	hsa-miR-4531	85.4584	NM_001322158
TCF12	hsa-miR-4327	85.4054	NM_001322158
TCF12	hsa-miR-7156-5p	85.282	NM_003205
TCF12	hsa-miR-6764-5p	85.2496	NM_003205
TCF12	hsa-miR-12122	85.2367	NM_003205
TCF12	hsa-miR-513a-3p	85.0443	NM_001322158
TCF12	hsa-miR-513c-3p	85.0443	NM_001322158
TCF12	hsa-miR-4472	84.9417	NM_001322159
TCF12	hsa-miR-607	84.5723	NM_001322158
TCF12	hsa-miR-185-5p	84.4777	NM_003205
TCF12	hsa-miR-671-5p	84.1052	NM_001322159
TCF12	hsa-miR-9851-5p	83.9651	NM_003205
TCF12	hsa-miR-3606-3p	83.8158	NM_001322158
TCF12	hsa-miR-6728-3p	83.5906	NM_003205
TCF12	hsa-miR-892a	83.3708	NM_001322154
TCF12	hsa-miR-6768-3p	83.3216	NM_001322159
TCF12	hsa-miR-1915-3p	83.3155	NM_003205
TCF12	hsa-miR-4762-5p	83.0172	NM_003205
TCF12	hsa-miR-675-3p	82.7931	NM_001322159
TCF12	hsa-miR-1285-3p	82.2025	NM_001322158
TCF12	hsa-miR-514a-3p	82.1568	NM_001322158
TCF12	hsa-miR-514b-3p	82.1568	NM_001322158

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Motifs and transcription factors (TFs) regulating TCF12

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TCF12	metacluster_135.11	NR2C2 (directAnnotation).
TCF12	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
TCF12	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TCF12	metacluster_7.13	ZFX (directAnnotation).
TCF12	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TCF12	cisbp__M00968	MTF2 (directAnnotation).
TCF12	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
TCF12	cisbp__M00341	PAX6 (directAnnotation).
TCF12	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
TCF12	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
TCF12	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
TCF12	cisbp__M00788	ZFY (inferredBy_Orthology).
TCF12	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
TCF12	hdpi__ZNF304	ZNF304 (directAnnotation).
TCF12	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
TCF12	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
TCF12	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
TCF12	transfac_pro__M01199	TRIM28 (directAnnotation).
TCF12	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
TCF12	metacluster_151.2	ZNF23 (directAnnotation).
TCF12	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TCF12	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TCF12	transfac_pro__M03806	ZBTB7C (directAnnotation).
TCF12	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."