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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SYT4

Summary for SYT4

Gene information	Gene symbol	SYT4
	Ensembl ID	ENSG00000132872
	Entrez ID	6860
	Gene name	synaptotagmin 4
	Synonyms	HsT1192\|KIAA1342
	Gene type	protein_coding
	UniProtAcc	Q9H2B2

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Dataset with differentially expressed gene: SYT4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.56872	0.00e+00

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Expression of SYT4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SYT4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SYT4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SYT4	hsa-miR-4670-3p	85.2821	NM_020783
SYT4	hsa-miR-12136	84.9888	NM_020783
SYT4	hsa-miR-424-5p	84.9343	NM_020783
SYT4	hsa-miR-513c-3p	84.8802	NM_020783
SYT4	hsa-miR-513a-3p	84.8802	NM_020783
SYT4	hsa-miR-1250-3p	84.2705	NM_020783
SYT4	hsa-miR-6793-3p	83.9054	NM_020783
SYT4	hsa-miR-129-1-3p	83.8565	NM_020783
SYT4	hsa-miR-129-2-3p	83.8565	NM_020783
SYT4	hsa-miR-548e-5p	83.8012	NM_020783
SYT4	hsa-miR-5584-5p	83.4172	NM_020783
SYT4	hsa-miR-1915-5p	83.142	NM_020783
SYT4	hsa-miR-655-5p	83.134	NM_020783
SYT4	hsa-miR-5589-3p	82.6944	NM_020783
SYT4	hsa-miR-15b-5p	82.3332	NM_020783
SYT4	hsa-miR-15a-5p	82.3332	NM_020783
SYT4	hsa-miR-6838-5p	82.3332	NM_020783
SYT4	hsa-miR-195-5p	82.3332	NM_020783
SYT4	hsa-miR-497-5p	82.3332	NM_020783
SYT4	hsa-miR-16-5p	82.3332	NM_020783
SYT4	hsa-miR-335-3p	82.2364	NM_020783
SYT4	hsa-miR-516a-3p	81.8598	NM_020783
SYT4	hsa-miR-7162-5p	81.8598	NM_020783
SYT4	hsa-miR-516b-3p	81.8598	NM_020783
SYT4	hsa-miR-3613-3p	81.2296	NM_020783
SYT4	hsa-miR-23b-3p	81.1334	NM_020783
SYT4	hsa-miR-23a-3p	81.1334	NM_020783
SYT4	hsa-miR-23c	81.1334	NM_020783
SYT4	hsa-miR-520e-5p	81.0919	NM_020783
SYT4	hsa-miR-22-5p	81.0381	NM_020783
SYT4	hsa-miR-3606-3p	80.9558	NM_020783
SYT4	hsa-miR-4495	80.875	NM_020783
SYT4	hsa-miR-9986	80.7814	NM_020783
SYT4	hsa-miR-1294	80.7814	NM_020783
SYT4	hsa-miR-196a-1-3p	80.73	NM_020783
SYT4	hsa-miR-4716-5p	80.4605	NM_020783
SYT4	hsa-miR-8068	80.326	NM_020783
SYT4	hsa-miR-205-3p	80.0655	NM_020783

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Motifs and transcription factors (TFs) regulating SYT4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."