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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SV2B

Summary for SV2B

Gene information	Gene symbol	SV2B
	Ensembl ID	ENSG00000185518
	Entrez ID	9899
	Gene name	synaptic vesicle glycoprotein 2B
	Synonyms	HsT19680\|KIAA0735
	Gene type	protein_coding
	UniProtAcc	Q7L1I2

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Dataset with differentially expressed gene: SV2B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.520514	3.62e-02

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Expression of SV2B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SV2B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SV2B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SV2B	hsa-miR-6864-3p	85.0536	NM_014848
SV2B	hsa-miR-3672	84.904	NM_014848
SV2B	hsa-miR-4713-5p	84.8003	NM_014848
SV2B	hsa-miR-6716-5p	84.6236	NM_014848
SV2B	hsa-miR-1285-5p	84.5748	NM_014848
SV2B	hsa-miR-6749-3p	84.3747	NM_014848
SV2B	hsa-miR-4641	84.3597	NM_014848
SV2B	hsa-miR-1248	84.1163	NM_014848
SV2B	hsa-miR-3664-3p	83.6055	NM_014848
SV2B	hsa-miR-6893-5p	82.4969	NM_014848
SV2B	hsa-miR-6808-5p	82.4969	NM_014848
SV2B	hsa-miR-940	82.2537	NM_014848
SV2B	hsa-miR-552-5p	82.2498	NM_014848
SV2B	hsa-miR-342-3p	81.3939	NM_014848
SV2B	hsa-miR-340-5p	81.3651	NM_014848
SV2B	hsa-miR-7158-5p	81.168	NM_014848
SV2B	hsa-miR-23b-3p	81.0914	NM_014848
SV2B	hsa-miR-23a-3p	81.0914	NM_014848
SV2B	hsa-miR-23c	81.0914	NM_014848
SV2B	hsa-miR-888-5p	80.604	NM_001167580
SV2B	hsa-miR-4773	80.5868	NM_014848
SV2B	hsa-miR-6841-3p	80.4838	NM_014848

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Motifs and transcription factors (TFs) regulating SV2B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."