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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: STRN3

Summary for STRN3

Gene information	Gene symbol	STRN3
	Ensembl ID	ENSG00000196792
	Entrez ID	29966
	Gene name	striatin 3
	Synonyms	PPP2R6B\|S/G2NA\|SG2NA
	Gene type	protein_coding
	UniProtAcc	Q13033

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Dataset with differentially expressed gene: STRN3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.871966	0.00e+00

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Expression of STRN3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to STRN3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating STRN3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
STRN3	hsa-miR-155-5p	89.1225	NM_001083893
STRN3	hsa-miR-548u	89.0394	NM_001083893
STRN3	hsa-miR-7702	88.6407	NM_001083893
STRN3	hsa-miR-2113	88.5701	NM_001083893
STRN3	hsa-miR-8087	88.5426	NM_001083893
STRN3	hsa-miR-5700	88.4385	NM_001083893
STRN3	hsa-miR-548t-5p	88.3086	NM_001083893
STRN3	hsa-miR-548az-5p	88.3086	NM_001083893
STRN3	hsa-miR-922	87.8687	NM_001083893
STRN3	hsa-miR-4536-5p	87.2233	NM_001083893
STRN3	hsa-miR-3145-5p	87.0021	NM_001083893
STRN3	hsa-miR-1305	86.481	NM_001083893
STRN3	hsa-miR-5692a	86.0206	NM_001083893
STRN3	hsa-miR-548au-3p	85.9603	NM_001083893
STRN3	hsa-miR-1323	85.6716	NM_001083893
STRN3	hsa-miR-4422	85.5489	NM_001083893
STRN3	hsa-miR-6835-3p	85.5489	NM_001083893
STRN3	hsa-miR-12130	84.9679	NM_001083893
STRN3	hsa-miR-4426	84.8511	NM_001083893
STRN3	hsa-miR-641	84.571	NM_001083893
STRN3	hsa-miR-3617-5p	84.571	NM_001083893
STRN3	hsa-miR-296-3p	84.3461	NM_001083893
STRN3	hsa-miR-582-5p	83.9944	NM_001083893
STRN3	hsa-miR-548h-3p	83.8319	NM_001083893
STRN3	hsa-miR-548bb-3p	83.8319	NM_001083893
STRN3	hsa-miR-548z	83.8319	NM_001083893
STRN3	hsa-miR-548ac	83.8319	NM_001083893
STRN3	hsa-miR-548d-3p	83.8319	NM_001083893
STRN3	hsa-miR-190a-3p	83.6884	NM_001083893
STRN3	hsa-miR-362-5p	83.6655	NM_001083893
STRN3	hsa-miR-500b-5p	83.6655	NM_001083893
STRN3	hsa-miR-4646-3p	83.281	NM_001083893
STRN3	hsa-miR-7114-5p	83.1355	NM_001083893
STRN3	hsa-miR-7-5p	82.4943	NM_001083893
STRN3	hsa-miR-10397-5p	82.4041	NM_001083893
STRN3	hsa-miR-4743-3p	82.4032	NM_001083893
STRN3	hsa-miR-8083	82.2262	NM_001083893
STRN3	hsa-miR-6771-3p	81.8598	NM_001083893
STRN3	hsa-miR-136-5p	81.8527	NM_001083893
STRN3	hsa-miR-548o-3p	81.5066	NM_001083893
STRN3	hsa-miR-15a-3p	81.2449	NM_001083893
STRN3	hsa-miR-708-3p	81.0106	NM_001083893
STRN3	hsa-miR-4766-3p	80.4394	NM_001083893
STRN3	hsa-miR-552-3p	80.1631	NM_001083893
STRN3	hsa-miR-153-5p	80.0132	NM_001083893

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Motifs and transcription factors (TFs) regulating STRN3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."