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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: STRN

Summary for STRN

Gene information	Gene symbol	STRN
	Ensembl ID	ENSG00000115808
	Entrez ID	6801
	Gene name	striatin
	Synonyms	PPP2R6A\|STRN1
	Gene type	protein_coding
	UniProtAcc	O43815

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Dataset with differentially expressed gene: STRN

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.273633	1.45e-18

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Expression of STRN in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to STRN

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating STRN

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
STRN	hsa-miR-137-3p	89.3172	NM_003162
STRN	hsa-miR-6721-5p	89.2418	NM_003162
STRN	hsa-miR-580-5p	89.1858	NM_003162
STRN	hsa-miR-1910-3p	88.8424	NM_003162
STRN	hsa-miR-200c-3p	88.7552	NM_003162
STRN	hsa-miR-429	88.7552	NM_003162
STRN	hsa-miR-200b-3p	88.7552	NM_003162
STRN	hsa-miR-570-3p	88.5576	NM_003162
STRN	hsa-miR-4680-3p	87.972	NM_003162
STRN	hsa-miR-922	87.8851	NM_003162
STRN	hsa-miR-6511a-5p	87.8792	NM_003162
STRN	hsa-miR-3175	87.6602	NM_003162
STRN	hsa-miR-195-3p	87.5795	NM_003162
STRN	hsa-miR-16-2-3p	87.5795	NM_003162
STRN	hsa-miR-548as-3p	87.5634	NM_003162
STRN	hsa-miR-539-5p	87.5453	NM_003162
STRN	hsa-miR-4793-5p	86.764	NM_003162
STRN	hsa-miR-4776-5p	86.6593	NM_003162
STRN	hsa-miR-4251	86.5425	NM_003162
STRN	hsa-miR-519d-5p	86.426	NM_003162
STRN	hsa-miR-527	86.1017	NM_003162
STRN	hsa-miR-518a-5p	86.1017	NM_003162
STRN	hsa-miR-4776-3p	86.03	NM_003162
STRN	hsa-miR-484	85.9923	NM_003162
STRN	hsa-miR-4536-5p	85.9228	NM_003162
STRN	hsa-miR-4306	85.6797	NM_003162
STRN	hsa-miR-6878-5p	85.2407	NM_003162
STRN	hsa-miR-4692	84.5104	NM_003162
STRN	hsa-miR-4699-3p	84.3819	NM_003162
STRN	hsa-miR-5190	84.2536	NM_003162
STRN	hsa-miR-5197-5p	84.2163	NM_003162
STRN	hsa-miR-4514	84.1172	NM_003162
STRN	hsa-miR-4789-5p	83.7793	NM_003162
STRN	hsa-miR-513a-5p	83.7094	NM_003162
STRN	hsa-miR-4742-5p	83.2781	NM_003162
STRN	hsa-miR-4666a-3p	83.2733	NM_003162
STRN	hsa-miR-571	83.2016	NM_003162
STRN	hsa-miR-4704-5p	82.9634	NM_003162
STRN	hsa-miR-5187-3p	82.7955	NM_003162
STRN	hsa-miR-491-5p	82.768	NM_003162
STRN	hsa-miR-3667-3p	82.6002	NM_003162
STRN	hsa-miR-3155a	82.2483	NM_003162
STRN	hsa-miR-3155b	82.2483	NM_003162
STRN	hsa-miR-493-3p	82.1577	NM_003162
STRN	hsa-miR-5680	82.1186	NM_003162
STRN	hsa-miR-4765	81.87	NM_003162
STRN	hsa-miR-1252-3p	81.615	NM_003162
STRN	hsa-miR-23b-3p	81.4968	NM_003162
STRN	hsa-miR-23a-3p	81.4968	NM_003162
STRN	hsa-miR-23c	81.4968	NM_003162

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Motifs and transcription factors (TFs) regulating STRN

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
STRN	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
STRN	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
STRN	metacluster_7.13	ZFX (directAnnotation).
STRN	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
STRN	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
STRN	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
STRN	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
STRN	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
STRN	cisbp__M00249	WT1 (directAnnotation).
STRN	cisbp__M01863	ZNF711 (inferredBy_Orthology).
STRN	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
STRN	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
STRN	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
STRN	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
STRN	taipale_cyt_meth__KLF12_NGCCGACGCCCW_FL_meth_repr	KLF12 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."