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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ST8SIA4

Summary for ST8SIA4

Gene information	Gene symbol	ST8SIA4
	Ensembl ID	ENSG00000113532
	Entrez ID	7903
	Gene name	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
	Synonyms	PST\|PST1\|SIAT8D
	Gene type	protein_coding
	UniProtAcc	Q92187

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Dataset with differentially expressed gene: ST8SIA4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.288986	2.52e-07

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Expression of ST8SIA4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ST8SIA4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ST8SIA4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ST8SIA4	hsa-miR-616-5p	84.4598	NM_005668
ST8SIA4	hsa-miR-6088	84.2488	NM_005668
ST8SIA4	hsa-miR-7154-5p	84.1444	NM_005668
ST8SIA4	hsa-miR-3671	84.1057	NM_175052
ST8SIA4	hsa-miR-466	83.5823	NM_005668
ST8SIA4	hsa-miR-4511	82.8998	NM_005668
ST8SIA4	hsa-miR-4762-3p	82.7789	NM_005668
ST8SIA4	hsa-miR-4774-3p	82.4886	NM_005668
ST8SIA4	hsa-miR-5007-3p	82.4407	NM_005668
ST8SIA4	hsa-miR-8087	82.4041	NM_175052
ST8SIA4	hsa-miR-587	82.2394	NM_005668
ST8SIA4	hsa-miR-4743-3p	82.1925	NM_175052
ST8SIA4	hsa-miR-4311	82.0235	NM_175052
ST8SIA4	hsa-miR-7112-3p	82.0223	NM_005668
ST8SIA4	hsa-miR-4666a-3p	81.7451	NM_005668
ST8SIA4	hsa-miR-451a	81.516	NM_175052
ST8SIA4	hsa-miR-5582-3p	81.1605	NM_005668
ST8SIA4	hsa-miR-4719	80.8066	NM_005668
ST8SIA4	hsa-miR-6731-3p	80.7042	NM_175052
ST8SIA4	hsa-let-7a-3p	80.4008	NM_005668
ST8SIA4	hsa-miR-548n	80.3984	NM_175052

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Motifs and transcription factors (TFs) regulating ST8SIA4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ST8SIA4	jaspar__MA1956.1	FOXO1 (directAnnotation).
ST8SIA4	jaspar__MA1954.1	FOXO1 (directAnnotation).
ST8SIA4	tfdimers__MD00145	ELF1; ELF2; ELK1; ELK4; ERF; ERG; ETS1; ETS2; ETV7; FLI1; TCF7L2 (directAnnotation).
ST8SIA4	jaspar__MA1946.1	FOXI1 (directAnnotation).
ST8SIA4	tfdimers__MD00221	FOXG1; FOXO1; GABPA (directAnnotation).
ST8SIA4	taipale_tf_pairs__RFX3_SREBF2_NNRGYAACNTCACGTGAY_CAP_repr	RFX3; SREBF2 (directAnnotation).
ST8SIA4	jaspar__MA1955.1	FOXO1 (directAnnotation).
ST8SIA4	tfdimers__MD00204	GABPA; NKX2-1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."