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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SRSF1

Summary for SRSF1

Gene information	Gene symbol	SRSF1
	Ensembl ID	ENSG00000136450
	Entrez ID	6426
	Gene name	serine and arginine rich splicing factor 1
	Synonyms	ASF\|MGC5228\|SF2\|SF2p33\|SFRS1\|SRp30a
	Gene type	protein_coding
	UniProtAcc	Q07955

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Dataset with differentially expressed gene: SRSF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.388117	1.82e-20
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.318535	6.70e-15
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.456133	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.364607	2.28e-21
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	0.267288	5.28e-28
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	-0.291263	6.94e-09
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.289515	4.12e-24
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.392936	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.339585	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.347953	1.51e-15
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.296829	5.69e-11
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.445817	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.261154	1.43e-10

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Expression of SRSF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SRSF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SRSF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SRSF1	hsa-miR-3064-3p	86.3115	NM_001078166
SRSF1	hsa-miR-548p	86.284	NM_001078166
SRSF1	hsa-miR-3167	86.2249	NM_006924
SRSF1	hsa-miR-377-3p	85.5555	NM_006924
SRSF1	hsa-miR-489-3p	85.3982	NM_006924
SRSF1	hsa-miR-4699-3p	85.2875	NM_001078166
SRSF1	hsa-miR-4421	84.9897	NM_001078166
SRSF1	hsa-miR-5582-3p	84.4969	NM_006924
SRSF1	hsa-miR-4502	83.6257	NM_006924
SRSF1	hsa-miR-5011-5p	82.6562	NM_006924
SRSF1	hsa-miR-676-5p	82.309	NM_001078166
SRSF1	hsa-miR-1468-3p	82.0842	NM_006924
SRSF1	hsa-miR-3974	81.9718	NM_001078166
SRSF1	hsa-miR-2355-5p	81.2449	NM_001078166
SRSF1	hsa-miR-452-3p	81.1821	NM_006924
SRSF1	hsa-miR-3529-3p	80.9935	NM_001078166
SRSF1	hsa-miR-6515-3p	80.8879	NM_006924
SRSF1	hsa-miR-206	80.8342	NM_006924
SRSF1	hsa-miR-1-3p	80.8342	NM_006924
SRSF1	hsa-miR-613	80.8342	NM_006924
SRSF1	hsa-miR-33a-3p	80.8246	NM_006924
SRSF1	hsa-miR-6793-3p	80.675	NM_001078166
SRSF1	hsa-miR-6772-3p	80.3776	NM_006924
SRSF1	hsa-miR-548g-3p	80.0187	NM_006924

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Motifs and transcription factors (TFs) regulating SRSF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SRSF1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
SRSF1	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
SRSF1	transfac_pro__M04950	EGR1 (directAnnotation).
SRSF1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
SRSF1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
SRSF1	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
SRSF1	transfac_pro__M00652	NRF1 (directAnnotation).
SRSF1	transfac_pro__M04866	HDAC2 (directAnnotation).
SRSF1	jaspar__MA1122.1	TFDP1 (directAnnotation).
SRSF1	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
SRSF1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
SRSF1	hdpi__TP73	TP73 (directAnnotation).
SRSF1	transfac_public__M00024	E2F1 (directAnnotation).
SRSF1	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
SRSF1	metacluster_55.5	ZNF541 (directAnnotation).
SRSF1	cisbp__M02645	ETS1 (directAnnotation).
SRSF1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
SRSF1	jaspar__MA0776.1	MYBL1 (directAnnotation).
SRSF1	kznf__ZNF653_Najafabadi2015_ChIP-seq	ZNF653 (directAnnotation).
SRSF1	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
SRSF1	transfac_pro__M06432	ZNF571 (directAnnotation).
SRSF1	transfac_pro__M06554	ZNF483 (directAnnotation).
SRSF1	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
SRSF1	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
SRSF1	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
SRSF1	taipale_tf_pairs__ELK1_FOXI1_WGTTKMCGGAWRTN_CAP	ELK1; FOXI1 (directAnnotation).
SRSF1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
SRSF1	metacluster_141.2	E2F2; E2F3 (directAnnotation).
SRSF1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
SRSF1	transfac_pro__M04794	TAF1 (directAnnotation).
SRSF1	taipale_tf_pairs__MYBL1_EOMES_RSGTGNNNAACGK_CAP_repr	EOMES; MYBL1 (directAnnotation).
SRSF1	homer__NCCACGTG_c-Myc	MYC (directAnnotation).
SRSF1	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
SRSF1	transfac_pro__M06032	ZNF727 (directAnnotation).
SRSF1	taipale_tf_pairs__ETV2_FOXI1_RNCGGAANNAAACA_CAP_repr	ETV2; FOXI1 (directAnnotation).
SRSF1	metacluster_81.7	CREB1 (directAnnotation).
SRSF1	nitta__CG18619_TCGAAG20NGA_KH_RTGACGTCAT_m1_c3u	CREBL2 (inferredBy_Orthology).
SRSF1	hocomoco__KAISO_HUMAN.H11MO.2.A	ZBTB33 (directAnnotation).
SRSF1	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
SRSF1	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
SRSF1	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SRSF1	"Copper"	DB09130	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."