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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SPTLC2

Summary for SPTLC2

Gene information	Gene symbol	SPTLC2
	Ensembl ID	ENSG00000100596
	Entrez ID	9517
	Gene name	serine palmitoyltransferase long chain base subunit 2
	Synonyms	hLCB2a\|KIAA0526\|LCB2\|LCB2A
	Gene type	protein_coding
	UniProtAcc	O15270

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Dataset with differentially expressed gene: SPTLC2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.266181	4.37e-02
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.274907	1.95e-32
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.656145	0.00e+00

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Expression of SPTLC2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SPTLC2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
SPTLC2	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating SPTLC2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SPTLC2	hsa-miR-4303	83.2917	NM_004863
SPTLC2	hsa-miR-500a-5p	82.6603	NM_004863
SPTLC2	hsa-miR-9985	82.4701	NM_004863
SPTLC2	hsa-miR-27b-3p	82.4701	NM_004863
SPTLC2	hsa-miR-27a-3p	82.4701	NM_004863
SPTLC2	hsa-miR-4698	81.849	NM_004863
SPTLC2	hsa-miR-3127-3p	81.6411	NM_004863
SPTLC2	hsa-miR-6756-3p	81.6411	NM_004863
SPTLC2	hsa-miR-6504-3p	81.3969	NM_004863
SPTLC2	hsa-miR-223-3p	81.1901	NM_004863
SPTLC2	hsa-miR-125b-2-3p	81.1744	NM_004863
SPTLC2	hsa-miR-939-3p	80.3776	NM_004863
SPTLC2	hsa-miR-1912-5p	80.2114	NM_004863

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Motifs and transcription factors (TFs) regulating SPTLC2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SPTLC2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
SPTLC2	jaspar__MA1483.2	ELF2 (directAnnotation).
SPTLC2	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
SPTLC2	swissregulon__hs__ETV6	ETV6 (directAnnotation).
SPTLC2	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
SPTLC2	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
SPTLC2	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
SPTLC2	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
SPTLC2	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
SPTLC2	transfac_pro__M04748	GABPA (directAnnotation).
SPTLC2	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
SPTLC2	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
SPTLC2	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).
SPTLC2	transfac_pro__M06032	ZNF727 (directAnnotation).
SPTLC2	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
SPTLC2	metacluster_52.13	LEF1; LEF1; LEF1; LEF1; TCF7; TCF7; TCF7L1; TCF7L1 (directAnnotation).
SPTLC2	tfdimers__MD00351	IRF8; RFX1; RFX2; RFX3; RFX4; RFX5; RFXANK; RFXAP (directAnnotation).
SPTLC2	transfac_pro__M06629	ZNF578 (directAnnotation).
SPTLC2	transfac_pro__M04706	RELA (directAnnotation).
SPTLC2	metacluster_22.33	MAFK (inferredBy_Orthology).
SPTLC2	transfac_pro__M06383	ZNF629 (inferredBy_Orthology).
SPTLC2	taipale_tf_pairs__HOXD12_ELK3_RSCGGAAGTCGTAAAN_CAP	ELK3; HOXD12 (directAnnotation).
SPTLC2	metacluster_23.5	WT1 (directAnnotation).
SPTLC2	transfac_pro__M06139	ZNF324 (directAnnotation).
SPTLC2	tfdimers__MD00404	FOXA1; FOXA2; FOXA3; FOXP3 (directAnnotation).
SPTLC2	metacluster_79.39	ATF6B (directAnnotation).
SPTLC2	kznf__ZNF485_Imbeault2017_RP_RCADE	ZNF485 (directAnnotation).
SPTLC2	metacluster_5.1	HIVEP1; HIVEP1; NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; NFKB2; NFKB2; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELB; RELB (directAnnotation). NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; REL; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELB; RELB; RELB (inferredBy_Orthology).
SPTLC2	hdpi__GTF3C2	GTF3C2 (directAnnotation).
SPTLC2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SPTLC2	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
SPTLC2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SPTLC2	metacluster_126.7	CTCF; ZFY; ZSCAN30 (directAnnotation).
SPTLC2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SPTLC2	"Pyridoxal phosphate"	DB00114	small molecule
SPTLC2	"Serine"	DB00133	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."