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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SPRY4

Summary for SPRY4

Gene information	Gene symbol	SPRY4
	Ensembl ID	ENSG00000187678
	Entrez ID	81848
	Gene name	sprouty RTK signaling antagonist 4
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SPRY4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.342618	6.66e-20
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.268677	4.52e-11

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Expression of SPRY4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SPRY4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SPRY4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SPRY4	hsa-miR-4516	83.0207	NM_001127496
SPRY4	hsa-miR-5006-5p	82.9458	NM_001127496
SPRY4	hsa-miR-4328	82.6459	NM_001127496
SPRY4	hsa-miR-6721-5p	82.3302	NM_001127496
SPRY4	hsa-miR-4719	82.1691	NM_001127496
SPRY4	hsa-miR-6794-5p	82.1192	NM_001127496
SPRY4	hsa-miR-8084	81.5224	NM_001127496
SPRY4	hsa-miR-3688-5p	81.4381	NM_001127496
SPRY4	hsa-miR-514b-3p	81.0984	NM_001127496
SPRY4	hsa-miR-514a-3p	81.0984	NM_001127496
SPRY4	hsa-miR-4648	80.9157	NM_001127496
SPRY4	hsa-miR-193a-5p	80.5574	NM_001127496
SPRY4	hsa-miR-4691-5p	80.5446	NM_001127496
SPRY4	hsa-miR-6792-3p	80.5446	NM_001127496
SPRY4	hsa-miR-5682	80.4391	NM_001127496
SPRY4	hsa-miR-504-5p	80.3467	NM_001127496
SPRY4	hsa-miR-4725-5p	80.3467	NM_001127496
SPRY4	hsa-miR-4727-5p	80.3302	NM_001127496
SPRY4	hsa-miR-6878-5p	80.2676	NM_001127496

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Motifs and transcription factors (TFs) regulating SPRY4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SPRY4	jaspar__MA0079.5	SP1 (directAnnotation).
SPRY4	transfac_pro__M01835	KLF4 (directAnnotation).
SPRY4	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
SPRY4	hocomoco__PATZ1_HUMAN.H11MO.1.C	PATZ1 (directAnnotation).
SPRY4	swissregulon__hs__MTA3	MTA3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."