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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SPRED1

Summary for SPRED1

Gene information	Gene symbol	SPRED1
	Ensembl ID	ENSG00000166068
	Entrez ID	161742
	Gene name	sprouty related EVH1 domain containing 1
	Synonyms	FLJ33903\|PPP1R147
	Gene type	protein_coding
	UniProtAcc	Q7Z699

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Dataset with differentially expressed gene: SPRED1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.382901	0.00e+00

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Expression of SPRED1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SPRED1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SPRED1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SPRED1	hsa-miR-1-3p	95.1449	NM_152594
SPRED1	hsa-miR-4501	94.6943	NM_152594
SPRED1	hsa-miR-6835-3p	94.625	NM_152594
SPRED1	hsa-miR-539-5p	94.4608	NM_152594
SPRED1	hsa-miR-5003-3p	94.2864	NM_152594
SPRED1	hsa-miR-206	94.2221	NM_152594
SPRED1	hsa-miR-6737-3p	93.9345	NM_152594
SPRED1	hsa-miR-7157-3p	93.9345	NM_152594
SPRED1	hsa-miR-4804-3p	93.5088	NM_152594
SPRED1	hsa-let-7b-3p	93.4561	NM_152594
SPRED1	hsa-miR-5008-3p	93.3773	NM_152594
SPRED1	hsa-miR-524-5p	93.2824	NM_152594
SPRED1	hsa-miR-520d-5p	93.2824	NM_152594
SPRED1	hsa-miR-8087	92.7536	NM_152594
SPRED1	hsa-miR-649	92.5562	NM_152594
SPRED1	hsa-miR-613	92.5262	NM_152594
SPRED1	hsa-miR-188-5p	92.491	NM_152594
SPRED1	hsa-miR-6866-3p	92.491	NM_152594
SPRED1	hsa-miR-147b-5p	92.4168	NM_152594
SPRED1	hsa-miR-7856-5p	92.3775	NM_152594
SPRED1	hsa-miR-1323	92.0706	NM_152594
SPRED1	hsa-miR-3160-5p	91.8857	NM_152594
SPRED1	hsa-let-7f-1-3p	91.8061	NM_152594
SPRED1	hsa-miR-98-3p	91.8061	NM_152594
SPRED1	hsa-let-7a-3p	91.8061	NM_152594
SPRED1	hsa-miR-4261	91.7974	NM_152594
SPRED1	hsa-miR-513c-3p	91.6736	NM_152594
SPRED1	hsa-miR-513a-3p	91.6736	NM_152594
SPRED1	hsa-miR-4760-5p	91.6571	NM_152594
SPRED1	hsa-miR-101-3p	91.2843	NM_152594
SPRED1	hsa-miR-6083	91.0957	NM_152594
SPRED1	hsa-miR-1305	90.9996	NM_152594
SPRED1	hsa-miR-3606-3p	90.9202	NM_152594
SPRED1	hsa-miR-410-3p	90.7812	NM_152594
SPRED1	hsa-miR-302c-5p	90.7308	NM_152594
SPRED1	hsa-miR-642b-3p	90.4888	NM_152594
SPRED1	hsa-miR-642a-3p	90.4888	NM_152594
SPRED1	hsa-miR-5700	90.4326	NM_152594
SPRED1	hsa-miR-4473	90.39	NM_152594
SPRED1	hsa-miR-595	90.3102	NM_152594
SPRED1	hsa-miR-374b-3p	90.2706	NM_152594
SPRED1	hsa-miR-6796-3p	90.2673	NM_152594
SPRED1	hsa-miR-3689f	90.1507	NM_152594
SPRED1	hsa-miR-3689a-5p	90.1507	NM_152594
SPRED1	hsa-miR-3689b-5p	90.1507	NM_152594
SPRED1	hsa-miR-3689e	90.1507	NM_152594
SPRED1	hsa-miR-195-3p	90.1177	NM_152594
SPRED1	hsa-miR-16-2-3p	90.1177	NM_152594
SPRED1	hsa-miR-146a-3p	89.9174	NM_152594
SPRED1	hsa-miR-8061	89.872	NM_152594

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Motifs and transcription factors (TFs) regulating SPRED1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SPRED1	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
SPRED1	metacluster_52.11	ZNF184 (directAnnotation).
SPRED1	metacluster_7.8	ZBTB7A; ZNF28 (directAnnotation).
SPRED1	metacluster_98.1	ZNF524 (directAnnotation).
SPRED1	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."