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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SPOPL

Summary for SPOPL

Gene information	Gene symbol	SPOPL
	Ensembl ID	ENSG00000144228
	Entrez ID	339745
	Gene name	speckle type BTB/POZ protein like
	Synonyms	BTBD33
	Gene type	protein_coding
	UniProtAcc	Q6IQ16

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Dataset with differentially expressed gene: SPOPL

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.299922	8.88e-19
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.561805	0.00e+00

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Expression of SPOPL in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SPOPL

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SPOPL

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SPOPL	hsa-miR-141-3p	89.7601	NM_001001664
SPOPL	hsa-miR-200a-3p	89.7601	NM_001001664
SPOPL	hsa-let-7b-3p	89.6442	NM_001001664
SPOPL	hsa-let-7a-3p	89.6442	NM_001001664
SPOPL	hsa-miR-98-3p	89.6442	NM_001001664
SPOPL	hsa-let-7f-1-3p	89.6442	NM_001001664
SPOPL	hsa-miR-519d-5p	89.5775	NM_001001664
SPOPL	hsa-miR-4762-3p	89.3873	NM_001001664
SPOPL	hsa-miR-590-3p	89.2974	NM_001001664
SPOPL	hsa-miR-4422	88.7546	NM_001001664
SPOPL	hsa-miR-450b-5p	88.6317	NM_001001664
SPOPL	hsa-miR-4477b	88.5657	NM_001001664
SPOPL	hsa-miR-223-5p	88.4553	NM_001001664
SPOPL	hsa-miR-7114-5p	87.9328	NM_001001664
SPOPL	hsa-miR-217-3p	87.8827	NM_001001664
SPOPL	hsa-miR-492	87.8813	NM_001001664
SPOPL	hsa-miR-4713-5p	87.8159	NM_001001664
SPOPL	hsa-miR-3924	87.5689	NM_001001664
SPOPL	hsa-miR-8485	87.3342	NM_001001664
SPOPL	hsa-miR-203a-3p	87.3286	NM_001001664
SPOPL	hsa-miR-584-5p	87.1567	NM_001001664
SPOPL	hsa-miR-548t-5p	87.0833	NM_001001664
SPOPL	hsa-miR-548az-5p	87.0833	NM_001001664
SPOPL	hsa-miR-374b-5p	87.0802	NM_001001664
SPOPL	hsa-miR-6845-3p	87.0701	NM_001001664
SPOPL	hsa-miR-144-3p	87.0145	NM_001001664
SPOPL	hsa-miR-2053	86.9846	NM_001001664
SPOPL	hsa-miR-5696	86.7117	NM_001001664
SPOPL	hsa-miR-4789-5p	86.6706	NM_001001664
SPOPL	hsa-miR-1250-3p	86.5796	NM_001001664
SPOPL	hsa-miR-6882-5p	86.3754	NM_001001664
SPOPL	hsa-miR-7975	85.9796	NM_001001664
SPOPL	hsa-miR-568	85.5756	NM_001001664
SPOPL	hsa-miR-7856-5p	85.3576	NM_001001664
SPOPL	hsa-miR-6768-5p	84.9732	NM_001001664
SPOPL	hsa-miR-4277	84.928	NM_001001664
SPOPL	hsa-miR-150-5p	84.7945	NM_001001664
SPOPL	hsa-miR-4291	84.7921	NM_001001664
SPOPL	hsa-miR-500a-5p	84.476	NM_001001664
SPOPL	hsa-miR-548ar-3p	84.0621	NM_001001664
SPOPL	hsa-miR-3691-3p	83.9535	NM_001001664
SPOPL	hsa-miR-4520-3p	83.5921	NM_001001664
SPOPL	hsa-miR-3616-5p	83.5691	NM_001001664
SPOPL	hsa-miR-573	83.5691	NM_001001664
SPOPL	hsa-miR-10522-5p	82.5207	NM_001001664
SPOPL	hsa-miR-548l	82.2568	NM_001001664
SPOPL	hsa-miR-20a-3p	81.8743	NM_001001664
SPOPL	hsa-miR-548a-3p	81.7194	NM_001001664
SPOPL	hsa-miR-548f-3p	81.7194	NM_001001664
SPOPL	hsa-miR-548e-3p	81.7194	NM_001001664

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Motifs and transcription factors (TFs) regulating SPOPL

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SPOPL	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
SPOPL	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
SPOPL	swissregulon__hs__CHD1	CHD1 (directAnnotation).
SPOPL	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SPOPL	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
SPOPL	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
SPOPL	transfac_pro__M12686	ZBTB10 (directAnnotation).
SPOPL	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
SPOPL	metacluster_143.14	ZNF320 (directAnnotation).
SPOPL	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
SPOPL	dbtfbs__ZBTB10_HEK293_ENCSR004PLU_merged_N1	ZBTB10 (directAnnotation).
SPOPL	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
SPOPL	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
SPOPL	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
SPOPL	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SPOPL	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
SPOPL	kznf__ZNF141_Imbeault2017_RP_RCADE	ZNF141 (directAnnotation).
SPOPL	transfac_pro__M04617	ZBTB7A (directAnnotation).
SPOPL	transfac_pro__M01973	PLAG1 (directAnnotation).
SPOPL	metacluster_151.2	ZNF23 (directAnnotation).
SPOPL	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SPOPL	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
SPOPL	metacluster_66.1	MTF1; ZNF320; ZNF320; ZNF320; ZNF782 (directAnnotation).
SPOPL	cisbp__M01864	EGR1 (inferredBy_Orthology).
SPOPL	tfdimers__MD00391	KLF4 (directAnnotation).
SPOPL	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
SPOPL	tfdimers__MD00151	CHURC1 (directAnnotation).
SPOPL	transfac_pro__M04817	ZBTB33 (directAnnotation).
SPOPL	cisbp__M00139	ZNF281 (inferredBy_Orthology).
SPOPL	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
SPOPL	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
SPOPL	transfac_public__M00491	PATZ1 (directAnnotation).
SPOPL	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
SPOPL	metacluster_3.10	KLF2; KLF4 (directAnnotation).
SPOPL	jaspar__MA1122.1	TFDP1 (directAnnotation).
SPOPL	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
SPOPL	transfac_pro__M01253	CNOT3 (directAnnotation).
SPOPL	metacluster_159.5	ZIC1; ZIC4; ZNF423 (directAnnotation). SP1 (inferredBy_Orthology).
SPOPL	cisbp__M00968	MTF2 (directAnnotation).
SPOPL	tfdimers__MD00038	TFAP2C (directAnnotation).
SPOPL	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
SPOPL	transfac_pro__M01199	TRIM28 (directAnnotation).
SPOPL	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
SPOPL	metacluster_3.14	WT1; WT1 (directAnnotation).
SPOPL	transfac_pro__M12697	ZNF142 (directAnnotation).
SPOPL	metacluster_84.2	RARA (directAnnotation).
SPOPL	transfac_pro__M01122	ZNF219 (directAnnotation).
SPOPL	transfac_pro__M07387	ZBTB7A (directAnnotation).
SPOPL	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SPOPL	transfac_pro__M04893	TAF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."