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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SOS2

Summary for SOS2

Gene information	Gene symbol	SOS2
	Ensembl ID	ENSG00000100485
	Entrez ID	6655
	Gene name	SOS Ras/Rho guanine nucleotide exchange factor 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q07890

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Dataset with differentially expressed gene: SOS2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.301339	4.51e-22

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Expression of SOS2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SOS2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SOS2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SOS2	hsa-miR-6835-3p	89.4864	NM_006939
SOS2	hsa-miR-5582-5p	88.9528	NM_006939
SOS2	hsa-miR-383-3p	88.6675	NM_006939
SOS2	hsa-miR-892b	88.1314	NM_006939
SOS2	hsa-miR-30a-3p	87.978	NM_006939
SOS2	hsa-miR-30d-3p	87.978	NM_006939
SOS2	hsa-miR-30e-3p	87.978	NM_006939
SOS2	hsa-miR-3176	87.7327	NM_006939
SOS2	hsa-miR-3922-3p	87.7327	NM_006939
SOS2	hsa-miR-4291	87.2137	NM_006939
SOS2	hsa-miR-199a-3p	87.1129	NM_006939
SOS2	hsa-miR-199b-3p	87.1129	NM_006939
SOS2	hsa-miR-936	87.1129	NM_006939
SOS2	hsa-miR-3129-5p	87.1129	NM_006939
SOS2	hsa-miR-548v	86.8999	NM_006939
SOS2	hsa-miR-224-5p	86.7062	NM_006939
SOS2	hsa-miR-98-3p	86.083	NM_006939
SOS2	hsa-let-7b-3p	86.083	NM_006939
SOS2	hsa-let-7f-1-3p	86.083	NM_006939
SOS2	hsa-let-7a-3p	86.083	NM_006939
SOS2	hsa-miR-6765-3p	85.6113	NM_006939
SOS2	hsa-miR-4717-5p	85.4348	NM_006939
SOS2	hsa-miR-6890-3p	85.3483	NM_006939
SOS2	hsa-miR-338-5p	84.6919	NM_006939
SOS2	hsa-miR-12136	84.3509	NM_006939
SOS2	hsa-miR-3619-5p	83.5765	NM_006939
SOS2	hsa-miR-154-5p	82.4334	NM_006939
SOS2	hsa-miR-3920	80.9067	NM_006939
SOS2	hsa-miR-19b-3p	80.437	NM_006939
SOS2	hsa-miR-19a-3p	80.437	NM_006939
SOS2	hsa-miR-590-5p	80.2773	NM_006939
SOS2	hsa-miR-21-5p	80.2773	NM_006939
SOS2	hsa-miR-1295b-3p	80.2302	NM_006939
SOS2	hsa-miR-3617-5p	80.2182	NM_006939
SOS2	hsa-miR-641	80.2182	NM_006939

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Motifs and transcription factors (TFs) regulating SOS2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SOS2	metacluster_135.11	NR2C2 (directAnnotation).
SOS2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SOS2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SOS2	metacluster_7.13	ZFX (directAnnotation).
SOS2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SOS2	cisbp__M00968	MTF2 (directAnnotation).
SOS2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SOS2	metacluster_198.3	ZFP64 (directAnnotation).
SOS2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SOS2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SOS2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
SOS2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SOS2	cisbp__M00788	ZFY (inferredBy_Orthology).
SOS2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SOS2	metacluster_175.1	ZNF283 (directAnnotation).
SOS2	hdpi__ZNF304	ZNF304 (directAnnotation).
SOS2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SOS2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SOS2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SOS2	transfac_pro__M01199	TRIM28 (directAnnotation).
SOS2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
SOS2	metacluster_151.2	ZNF23 (directAnnotation).
SOS2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SOS2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SOS2	transfac_pro__M03806	ZBTB7C (directAnnotation).
SOS2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."