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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: SNX27

Summary for SNX27

Gene informationGene symbol

SNX27

Ensembl ID

ENSG00000143376

Entrez ID

81609

Gene namesorting nexin 27
SynonymsKIAA0488|MGC20471|MY014
Gene typeprotein_coding
UniProtAcc

NA


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Dataset with differentially expressed gene: SNX27

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE139386

H3122 cell lineCell lineLung cancerEML4-ALK fusion-positive non-small cell lung cancer (NSCLC)Targeted therapyceritinibNAMalignant cells0.7720680.00e+00

GSE108397

451Lu cell lineCell lineMelanomaMelanomaTargeted therapyPLX-4720NAMalignant cells-0.4370950.00e+00

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Expression of SNX27 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to SNX27

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SNX27

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
SNX27hsa-miR-427985.7302NM_030918
SNX27hsa-miR-95-5p85.3569NM_030918
SNX27hsa-miR-674584.5529NM_030918
SNX27hsa-miR-6739-5p84.2821NM_030918
SNX27hsa-miR-6733-5p84.2821NM_030918
SNX27hsa-miR-873-5p84.224NM_030918
SNX27hsa-miR-548as-3p83.905NM_030918
SNX27hsa-miR-448683.3124NM_030918
SNX27hsa-miR-315383.1144NM_030918
SNX27hsa-miR-6817-3p83.0464NM_030918
SNX27hsa-miR-7160-5p82.8125NM_030918
SNX27hsa-miR-453382.7607NM_030918
SNX27hsa-miR-451682.2262NM_030918
SNX27hsa-miR-950082.1925NM_030918
SNX27hsa-miR-607181.5244NM_030918
SNX27hsa-miR-363-5p80.7734NM_030918
SNX27hsa-miR-6782-3p80.6612NM_030918
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Motifs and transcription factors (TFs) regulating SNX27

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
SNX27metacluster_7.13ZFX (directAnnotation).
SNX27metacluster_170.2KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
SNX27transfac_pro__M05479ZNF580 (directAnnotation).
SNX27metacluster_155.23BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SNX27kznf__ZNF783_Imbeault2017_OM_MEMEZNF783 (directAnnotation).
SNX27metacluster_144.3ZNF704; ZNF704 (directAnnotation).
SNX27hocomoco__KLF13_HUMAN.H11MO.0.DKLF13 (directAnnotation).
SNX27metacluster_135.10MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SNX27jaspar__MA0079.5SP1 (directAnnotation).
SNX27taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAPETV1; GCM1 (directAnnotation).
SNX27taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAPATF4; TEF (directAnnotation).
SNX27transfac_pro__M06213ZNF267 (directAnnotation).
SNX27kznf__ZNF282_Imbeault2017_OM_RCADEZNF282 (directAnnotation).
SNX27metacluster_7.8ZBTB7A; ZNF28 (directAnnotation).
SNX27metacluster_98.1ZNF524 (directAnnotation).
SNX27taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2ELK1; GCM1 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."